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Clinical Practice GuidelineVol. 12 · 2026

Consensus statements published by professional societies establish the evidentiary framework for routine clinical practice. These documents are, of necessity, abstract: they describe the population, not the patient. The published recommendation captures the median case, the modal outcome, the trial-eligible subgroup, and cannot anticipate the comorbidity profile, prior treatment history, or bedside reality that defines a given encounter.

Read between
the guidelines.

Mednet is a community where doctors find answers to medicine's toughest questions.

Section 2.4 acknowledges that "individualization of care remains the responsibility of the treating physician, informed by clinical judgment and the consensus of peers." What follows is not a substitute for the published guideline. It is a record of what practicing physicians do when the formal statement stops short — the dosing adjustments, the sequencing decisions, the contraindications, and the salvage protocols that consensus committees do not enumerate. Mednet surfaces this collective practice wisdom: a verified, peer-reviewed network indexed by specialty, indication, and pharmacologic class. Access is restricted to credentialed clinicians and remains the most cited source of post-publication guidance in the United States.

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Cardiology

How are you adjusting DOAC dosing in CKD pts with eGFR < 30?

+12 expert replies

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See how leading specialists reason through complex cases, gray areas, and the decisions guidelines leave open.

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Primary prevention statins in pts >75?

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Vote in clinical polls and see how other physicians approach dosing, sequencing, and surveillance.

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Journal Club · NEJM

T-DXd plus Pertuzumab for HER2+ Metastatic Breast Cancer

Sara M. Tolaney, MD, MPH
Stephen Liu, MD

03

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Mike Rich, MD

Mike Rich, MD

Professor · Washington University School of Medicine

Cardiology

Matthew Tomey, MD

Matthew Tomey, MD

Associate Professor · Mount Sinai Heart

Cardiology

Antonella Tosti, MD

Antonella Tosti, MD

Professor of Clinical Dermatology & Cutaneous Surgery · University of Miami Health

Dermatology

Michael Payette, MD

Michael Payette, MD

Associate Professor · UCONN

Dermatology

John Buse, MD

John Buse, MD

Professor · UNC

Endocrinology

Michael Holick, MD,PhD

Michael Holick, MD,PhD

Professor · Boston University School of Medicine

Endocrinology

Sunanda Kane, MD

Sunanda Kane, MD

Gastroenterologist · Mayo Clinic

Gastroenterology

Stephen Hanauer, MD

Stephen Hanauer, MD

Professor · Northwestern Medicine

Gastroenterology

Joseph Antin, MD

Joseph Antin, MD

Professor · Dana-Farber Cancer Institute

Hematology

Nancy Berliner, MD

Nancy Berliner, MD

Professor · Harvard Medical School

Hematology

From physicians

Mednet gives me direct access to content experts beyond my own academic center. They share their approaches to complex dermatology questions and point to valuable clinical and basic science research. I use Mednet discussions to supplement my literature review and stay current with the latest advances in my field.

Reid Oldenburg, MD, PhD

Reid Oldenburg, MD, PhD

Dermatology · University of California San Diego

I use Mednet to search for answers to clinical questions that I encounter during my routine practice. I often find my questions have been asked previously and have highly valuable answers from experienced disease site experts in radiation oncology. I also receive regular emails from Mednet with the most recent questions which often discuss new research developments. This helps me stay up to date on new studies and survey how others are interpreting and implementing new findings into daily practice.

Adnan M. Elhammali, MD

Adnan M. Elhammali, MD

Radiation Oncology · Northeast Georgia Health System

Mednet provides a wealth of information through experts in different fields of Neurology. This is super helpful to search for more detail on topics that we have seen on rounds, but more importantly, to know that the information is coming from experts in their field. Often, it's hard to find accurate answers to specific questions in textbooks, and that gap is being filled by Mednet.

Mohammed R. Ghani, MD

Mohammed R. Ghani, MD

Neurology · National Institute of Neurological Disorders and Stroke, NIH

Mednet has been invaluable to the way I approach complex patients or unique clinical scenarios, especially as a resident physician still in training. I am at a large academic residency program and we often see very complex medical dermatology cases. Even though I am surrounded by outstanding physicians, we still run into gray areas or clinical scenarios which are not expanded upon in the literature yet. Being able to post questions to hundreds of experts on Mednet allows me to acquire clinical pearls from physicians all over the country and has been the catalyst to some very insightful discourse amongst myself and my attending physicians.

Hanna Ahmed, MD

Hanna Ahmed, MD

Dermatology · The Dermatology Group PA

It's great to read the varying perspectives from more than one colleague on the same topic and see where they diverge or converge in their opinions. Many of the topics are directly relevant to issues I face daily, so it has facilitated some quick literature review and helped me provide the best care possible for my patients.

Jonathan Samuels, MD

Jonathan Samuels, MD

Rheumatology · NYU Langone Health

I use this platform to get feedback on challenging clinical situations, gray areas where the data is not clear, or clinical situations where data is lacking. It's also nice to get expert opinions and interpretation of data. Bottom line, I come here to get answers to improve my practice and to learn!

Ming-Jin Wang, DO

Ming-Jin Wang, DO

Internal Medicine · UMass Memorial Medical Center

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