After WBRT, what systemic therapy would you favor for maximal CNS penetrance in a patient with triple negative metastatic breast cancer and multifocal CNS disease?

With patients such as this, I would usually recommend the following:

1. Genomic testing (Strata, Foundation 1, etc.) to look for a mutation that might be targetable with a TKI that crosses the blood brain barrier well

2. Re-testing of the CNS cytology for HER2, given that we do have multiple drugs w...