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Are there any adverse risk factors in stage I colon cancer that would warrant ctDNA testing?
If a stage I colon cancer had positive ctDNA after surgery, what treatment, if any, would you recommend and for how long?
Answer from: Medical Oncologist at Academic Institution
I would not check ctDNA in this setting. If there is an adverse feature of the tumor and the patient is a candidate for further treatment, I would do close surveillance imaging and CEA at the most. A recent publication of a larger cohort study of stage II to IV resected colorectal cancer suggests th...
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Answer from: Medical Oncologist at Academic Institution
No. And, what would you do then? Give FOLFOX for stage 1 without real data on risk? CIRCULATE-Japan is inadequate for stage 1 data.
Answer from: Medical Oncologist at Academic Institution
This is a great question and we have limited data. The best evidence would be from the CIRCULATE-Japan study which included 228 pathological stage I colon cancer patients. The positive rate in this population is extremely low in the MRD window (only 2 positive, means a positive rate of <1%) ...
Answer from: Medical Oncologist at Community Practice
The risk of recurrence for T2N0 colon cancer is around 10–15% after surgery, but it can vary depending on the patient and other factors. Similar to well-described high-risk factors for recurrence in T3 N0 colon cancer (exclusive of those cancers that are MSI-H), such as poorly d...