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Are there any volumetric constraints associated with toxicity in the dose range that is moderately above prescription (i.e. 30-35 Gy range), when planning hippocampal-sparing whole brain radiation?

While protocols describe using a D2% constraint, there is little description of what should happen to the DVH between 30-37.5 Gy. It would be helpful to know what volume of brain receiving >30Gy is acceptable with this technique.

Answer from: Radiation Oncologist at Community Practice

This is an important question worth some discussion. As the question mentions, clinical trials of HA-WBRT have permitted a hot spot of 133% of the prescription dose of 30 Gy (or 40 Gy) to D2% of the whole-brain parenchyma as an acceptable protocol variation. Importantly, none of these trials have de...

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Radiation Oncologist at Mallory Radiotherapy, PLLC
I think the question is regarding concern over dos...

Please select the option that best describes you:

Are there any volumetric constraints associated with toxicity in the dose range that is moderately above prescription (i.e. 30-35 Gy range), when planning hippocampal-sparing whole brain radiation?

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