Are there particular adjuvant therapy considerations for locally advanced HNSCC patients who are found to have metastatic involvement of cystic lymph nodes during surgery?  

Adjuvant therapy for resected cystic lymph nodes should be based on pathologic risk features e.g. extra-nodal extension, per guideline recommendations (no special considerations). Note that large fluid-filled cystic nodes are characteristic of squamous cancers originating from Waldeyer's ring that a...