Are there situations where it's appropriate to offer postmastectomy radiation therapy to patients with biopsy-proven M1 disease?  

The two randomized studies evaluating benefit of local treatment for stage IV breast cancer at diagnosis were negative for the end point of improving survival. One from Turkey which randomized patients to upfront local treatment vs. none showed a trend for improved survival for bone only disease on ...

Short answer -- I agree with the answers above and think we have no good data to answer this question. Long answer -- For now, I divide patients into two groups: 1) Those patients with "oligometastatic disease" who we have decided to treat with a curative paradigm (e.g., a soli...

There are two situations when it should be considered: 1. After ablative treatment of a solitary met. 2. Known gross residual disease after neo-adjuvant chemo with clearance of mets.