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Can radiation therapy alone for localized recurrence of high-grade B-cell lymphoma be considered for those that previously received rituximab-based chemotherapy?
In particular, for frail patients to avoid toxicity or for those that do not want chemotherapy
Answer from: Radiation Oncologist at Academic Institution
High-grade B-cell lymphomas are distinct entities no longer classified as "diffuse large B-cell lymphoma" by the WHO. They include:
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (often referred to as double hit or triple hit lymphoma).
High-grade B-cell lymphoma, NOS (t...
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