General Internal Medicine

Myelodysplastic Syndromes

Questions discussed in this category

How do you approach severe anemia and thrombocytopenia in an elderly patient whose bone marrow biopsy shows hypercellular marrow with mild dysplasia in erythroid and megakaryocytic lineage but normal cytogenetics and a negative NGS panel?

Hgb is 8 and platelets 10. A very small PNH clone (0.08%) detected. No evidence of hemolysis. No response to steroids. All other anemia/thrombocytopen...

1 Answer available

How do you approach management for CCUS with severe cytopenias?

Bone marrow biopsy does not meet criteria for MDS and no other identifiable cause of the cytopenias.

1 Answer available

What are common indications for ordering NGS of peripheral blood?

Would a negative NGS eliminate the possibility of MDS? Is bone marrow biopsy indicated in a patient with pancytopenia with a negative NGS panel?

1 Answer available

Papers discussed in this category

Journal of the American Medical Association, 1953 Jul 11

Preleukemic acute human leukemia.

Blood advances, 2023 Jul 25

Utility of targeted gene sequencing to differentiate myeloid malignancies from other cytopenic conditions.

Nature genetics, 2023 Aug 24

Multiparameter prediction of myeloid neoplasia risk.

NEJM evidence, 2022 Jun 12

Molecular International Prognostic Scoring System for Myelodysplastic Syndromes.

Haematologica, 2024 Oct 24

Genome sequencing in the management of myelodysplastic syndromes and related disorders.

General Internal Medicine

Myelodysplastic Syndromes

Questions discussed in this category

Papers discussed in this category

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