Gynecologic Cancers

Gestational Trophoblastic Disease

Questions discussed in this category

What are your top takeaways from SGO 2023?

What is your approach to first line systemic treatment for low risk gestational trophoblastic neoplasia?

Is there an optimal chemotherapy regimen that optimizes cure rates while minimizing side effects?

How does your approach to low-risk gestational trophoblastic neoplasia differ for patients whose hCG levels plateau following initial single agent systemic therapy vs those who have a good initial response and then plateau?

1 Answer available

In a patient with high-risk gestational trophoblastic neoplasia, how would you approach treatment of recurrence at 6 months post EMA-CO?

Tolerated first line, however now with rising Beta-HCG, new mass in uterus, and pulmonary metastases.

1 Answer available

Would you offer adjuvant therapy for a patient with stage I high risk invasive mole after hysterectomy?

WHO score 8, for initial beta hCG, tumor size, and failure to respond to inpatient high dose MTX therapy (given as patient originally desired fertilit...

1 Answer available

How do you manage intracranial metastases from gestational trophoblastic neoplasia?

When would you recommend SRS vs WBRT?

1 Answer available

Papers discussed in this category

The Journal of reproductive medicine, 2012

Brain metastasis in gestational trophoblastic neoplasia: an update.

Gynecologic oncology, 2007-03

High-risk gestational trophoblastic neoplasia with brain metastases: individualized multidisciplinary therapy in the management of four patients.

Int J Gynaecol Obstet,

Update on the diagnosis and management of gestational trophoblastic disease.

Gynecologic oncology, 2012-06

Treatment of nonmetastatic and metastatic low-risk gestational trophoblastic neoplasia: factors associated with resistance to single-agent methotrexate chemotherapy.

Gynecologic oncology, 2017-01

15years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage.

, 2007 Jul 06

A review of the management by hysterectomy of 25 cases of gestational trophoblastic tumours from March 1993 to January 2006.

Role of hysterectomy in managing persistent gestational trophoblastic disease.

Gynecol Oncol, 2017 Apr 05

The added value of hysterectomy in the management of gestational trophoblastic neoplasia.

Cochrane Database Syst Rev, 2016 Jun 09

First-line chemotherapy in low-risk gestational trophoblastic neoplasia.

BMC Cancer, 2021 Oct 18

Direct comparisons of efficacy and safety between actinomycin-D and methotrexate in women with low-risk gestational trophoblastic neoplasia: a meta-analysis of randomized and high-quality non-randomized studies.

N Engl J Med, 2023 Mar 27

Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer.

N Engl J Med, 2023 Mar 27

Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer.

Gynecologic Cancers

Gestational Trophoblastic Disease

Questions discussed in this category

Papers discussed in this category

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