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Gynecologic Cancers

Uterine Cancer   

Questions discussed in this category

For a localized vaginal cuff recurrence of uterine leiomyosarcoma, what is the preferred management strategy?
Do you prefer surgery (i.e. exenteration) given the radioresistant histology or would you attempt to manage with EBRT and brachytherapy?
1 Answer available
When the initial diagnosis of stage I uterine leiomyosarcoma is made via a non-intact resection such as a myomectomy or supracervical hysterectomy, what factors, if any, might push you to consider adjuvant chemotherapy after completion surgery?
1 Answer available
What is your treatment approach for a pediatric patient with uterine embryonal rhabdomyosarcoma found after removal of a prolapsing uterine mass, with no evidence of distant metastasis on imaging?
1 Answer available
Do you routinely perform bilateral oophorectomy at the time of hysterectomy for a premenopausal woman with a uterine leiomyosarcoma that appears to be limited to the uterus?
Does ER/PR status help guide your decision?
1 Answer available
Would you give adjuvant therapy after diagnosis of presumed stage IA, 5cm, ER/PR+ uterine adenosarcoma on a total hysterectomy with bilateral salpingoopheretomy without staging?
No sarcomatous overgrowth seen.
1 Answer available
What is your approach to adjuvant therapy for a fully resected (contained morcellation and laparoscopic removal), isolated retroperitoneal leiomyosarcoma in a patient with a remote history of a hysterectomy?
1 Answer available
How would you manage a recurrent uterine leiomyosarcoma, now status post secondary cytoreduction, with no gross residual disease?
Would you consider adjuvant chemotherapy, radiation therapy, hormone therapy, or surveillance?
1 Answer available
What is your treatment approach to a young woman with widely metastatic low grade endometrial stromal sarcoma not amenable to complete cytoreduction?
Would you consider "neoadjuvant" hormonal therapy to shrink tumors and potentially make more amenable to complete cytoreduction at a later date? Woul...
1 Answer available
Would you offer adjuvant progesterone therapy to a young woman with low grade endometrial stromal sarcoma who had elected ovarian conservation?
1 Answer available
What adjuvant treatment would you offer a young woman with stage IB uterine mullerian adenosarcoma with sarcomatous overgrowth?
1 Answer available
Would you offer adjuvant radiation to a patient with uterine undifferentiated sarcoma s/p resection, vaginal cuff recurrence, and re-resection?
If so, would you treat the whole pelvis, cuff brachytherapy, or both?
2 Answers available


Papers discussed in this category

Gynecologic oncology, 2003-07
Low-grade endometrial stromal sarcoma: hormonal aspects.
Obstetrics and gynecology, 2013-09
Endometrial stromal sarcoma: a systematic review.
Lancet Oncol.,
Clinical management of uterine sarcomas.
Gynecol. Oncol., 2005 Dec 20
Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma: single center experience with 10 cases and review of the literature.
Int J Gynecol Cancer,
Long-Term Outcome of Aromatase Inhibitor Therapy With Letrozole in Patients With Advanced Low-Grade Endometrial Stromal Sarcoma.
Gynecologic oncology, 2001-10
Uterine adenosarcoma with sarcomatous overgrowth versus uterine carcinosarcoma: comparison of treatment and survival.
Int. J. Gynecol. Pathol.,
Adenosarcoma of the uterus: a Gynecologic Oncology Group clinicopathologic study of 31 cases.
Eur. J. Cancer, 2008 Apr 02
Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874).
J Clin Oncol,
A randomized clinical trial of adjuvant adriamycin in uterine sarcomas: a Gynecologic Oncology Group Study.
Pediatric blood & cancer, 2018-02
Consensus and controversies regarding the treatment of rhabdomyosarcoma.

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