Thrombocytopenia   

Received dexamethasone 40 mg daily x4 and IVIG without response. No DIC. PB flow cytometry and bone marrow biopsy without pathology. Are there specifi...

How would you counsel the patient if he/she wants to continue on steroids?

I.e. platelet count <30. Would your management change if HIT were only suspected rather than confirmed?  

Provided that the platelet count is normal, do you usually consider this to be a potential erroneous result or do you pursue additional workup for RBC...

Such as the case in which a patient is unresponsive to steroids, IVIG, TPO-agonist, rituximab, splenectomy, and even fostamitinib.

ADAMTS13 level <5% Inhibitor level <1

Wu et al., PMID 34665865 

Presuming strong indication for ASA - eg history of NSTEMI

e.g. DITP from eptifibatide after a cardiac intervention

IVIG, TPO, or other agents?

How often do you monitor ADAMTS-13 levels off therapy?

For example, do we prefer one regimen over the other in patients with a bleeding history or who have relapsed after a lengthy remission?