Radiation Oncology

Cutaneous Squamous Cell Carcinoma

Questions discussed in this category

How would you manage a scalp squamous cell carcinoma s/p Mohs with high risk features who underwent placental grafting to expedite the healing process?

When is it safe to deliver adjuvant radiation?

1 Answer available

How would you approach treatment failures with squamous cell carcinoma-keratoacanthoma-type lesions that did not respond to a standard SRT regimen after many sessions?

Have you encountered this scenario?

3 Answers available

Do you obtain MRI for cutaneous SCC with microscopic PNI to assess for gross perineural tumor spread?

Are there other settings where MRI is used for nerve assessment and radiation planning such as for certain definitive RT cases?

4 Answers available

Are you routinely using neoadjuvant cemiplimab for cutaneous squamous cell carcinoma of any site?

Majority of patients on the seminal trial (Gross et al., PMID 36094839) had tumors isolated to head & neck, what was the rationale for this?

4 Answers available

Would you continue cemiplimab or pembrolizumab adjuvantly, following resection of initially unresectable cutaneous squamous cell carcinoma?

Do you base your decision on extent of residual disease? Does the use of (neo)adjuvant immunotherapy have an impact on surgical site size or he...

4 Answers available

Is the phase 2 data regarding neoadjuvant cemiplimab in cutaneous squamous cell carcinoma sufficient to adopt for all patients or will you await phase 3 data?

Is a placebo-controlled trial anticipated?

6 Answers available

Do you consider downstaging neoadjuvant cemiplimab for borderline resectable CSCC in order to facilitate surgical resection?

3 Answers available

Papers discussed in this category

N Engl J Med, 2022 Sep 12

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma.

Front Oncol, 2023 Jan 04

Case report: The power of immunotherapy in advanced cutaneous squamous cell carcinoma.

Br J Dermatol, 2015 Aug 08

Efficacy of neoadjuvant cetuximab alone or with platinum salt for the treatment of unresectable advanced nonmetastatic cutaneous squamous cell carcinomas.

J. Clin. Oncol., 2018 Mar 14

Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016 Jul 27

Skin cancer of the head and neck with gross or microscopic perineural involvement: Patterns of failure.

Archives of otolaryngology--head & neck surgery, 2004-11

Radiation therapy does not impact local complication rates after free flap reconstruction for head and neck cancer.

Ear, nose, & throat journal, 2020 Jul 07

Predictors of Free Flap Volume Loss in Nonosseous Reconstruction of Head and Neck Oncologic Defects.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020 Sep 03

Flap delineation guidelines in postoperative head and neck radiation therapy for head and neck cancers.

Frontiers in oncology, 2024 Apr 11

Reconstructive flap surgery in head and neck cancer patients: an interdisciplinary view of the challenges encountered by radiation oncologists in postoperative radiotherapy.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2022 Feb 26

Postoperative radiotherapy delay in head and neck cancer patients undergoing major resection and free flap reconstruction.

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