Adrenocortical Carcinoma

Questions discussed in this category

For a completely resected high risk adrenal cortical carcinoma with a high mitotic rate, what is your approach to adjuvant therapy?

When do you use mitotane?

1 Answer available

Do you offer postoperative radiation for adrenocortical carcinoma?

If so, how would you design and deliver the treatment?

1 Answer available

Would you offer immunotherapy first line for patients with adrenocortical carcinoma outside of a clinical trial?

The phase 2 trial of pembrolizumab in JCO 2019 showed efficacy, and I have patients preferring to avoid chemotherapy.

1 Answer available

Papers discussed in this category

International journal of radiation oncology, biology, physics, 2015-06-01

Adjuvant radiation therapy improves local control after surgical resection in patients with localized adrenocortical carcinoma.

American journal of clinical oncology, 1991-04

Radiation therapy for adjunctive treatment of adrenal cortical carcinoma.

Surgery, 2012-12

Resection of adrenocortical carcinoma is less complete and local recurrence occurs sooner and more often after laparoscopic adrenalectomy than after open adrenalectomy.

Annals of surgical oncology, 2018-07

Adjuvant Radiation is Associated with Improved Survival for Select Patients with Non-metastatic Adrenocortical Carcinoma.

Cancer,

Radiotherapy in adrenocortical carcinoma.

J Clin Endocrinol Metab, 2006 Aug 08

Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma.

J Cancer Res Ther,

Adjuvant radiotherapy after surgical resection for adrenocortical carcinoma: A systematic review of observational studies and meta-analysis.

J Clin Endocrinol Metab,

Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma.

J Endocr Soc, 2019 Oct 11

Response to Immunotherapy in Combination With Mitotane in Patients With Metastatic Adrenocortical Cancer.

J Clin Oncol, 2020 Jan 1

PD-1 Blockade in Advanced Adrenocortical Carcinoma.

Journal of the American College of Surgeons, 2016-04

Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group.

Urol Oncol, 2021 Jul 20

Identification of oncological characteristics associated with improved overall survival in patients with adrenocortical carcinoma treated with adjuvant radiation therapy: Insights from the National Cancer Database.

N Engl J Med,

Adjuvant mitotane treatment for adrenocortical carcinoma.

Cancers (Basel), 2020 Sep 14

Unwanted Hormonal and Metabolic Effects of Postoperative Adjuvant Mitotane Treatment for Adrenocortical Cancer.

Am J Surg, 2020 Nov 04

Analysis of adjuvant chemotherapy in patients undergoing curative-intent resection of localized adrenocortical carcinoma.

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