Endocrinology

There seems to be little guidance on vitamin replacement in these patients. Vitamin K level < 50 yet PT/INR is normal. Is the vitamin K assay usefu...

1 Answer available

Is tall cell variant papillary thyroid cancer automatically categorized as intermediate risk regardless of other histopathological features and should consequently be treated with RAI?

A female in her early 70s, total thyroidectomy, left 1.4 cm and right 0.7 cm tall cell variant papillary thyroid cancer with clear margins and negativ...

1 Answer available

What factors would lead you to extend the duration of antithyroid drug therapy in a patient with Graves' disease who is clinically euthyroid at 12 months but has risk factors for recurrence?

2 Answers available

Do you recommend adjusting the duration of a drug holiday based on the specific bisphosphonate used when treating osteoporosis?

1 Answer available

Would elevated bone mineral density/T-score be enough to make a diagnosis of osteopetrosis?

1 Answer available

Does the presence of osteoporosis change the extent of workup that should be performed for an older patient with otherwise serologically low-risk MGUS?

Would your considerations change for a man vs a woman?

1 Answer available

What is the therapeutic role and blood glucose lowering capability of bromocriptine and cholestyramine for the treatment of Type 2 diabetes?

2 Answers available

Should we recommend SGLT2i initiation at discharge to all patients hospitalized with acute myocardial infarction?

Butler et al., PMID 38587237

1 Answer available

How many days prior to surgery do you recommend stopping SGLT2 inhibitors and when is it safe to resume therapy?

1 Answer available

Would you recommend RAI ablation therapy to patients with PTC who are s/p hemi-thyroidectomy and decline completion thyroidectomy despite meeting criteria based on pathology results?

1 Answer available

What is the likelihood of recovery of parathyroid gland function for patients who underwent total thyroidectomy, found to have embedded parathyroid glands intra-operatively and then subsequently had them re-implanted into neck muscle?

1 Answer available

When do you recommend plasmapheresis/plasma exchange for management of severe hypertriglyceridemia?

2 Answers available

Would you order a repeat DEXA scan 1 year later for a kidney transplant patient who had an initial DEXA scan within the first 6 months post-transplant showing osteopenia but no history of fractures, and who has been stable on glucocorticoid-free immunosuppressive therapy?

2 Answers available

Would you recommend waiting for a low Vitamin D level to correct to goal prior to giving a scheduled Prolia injection when transitioning a patient from Zolendronic acid to Prolia therapy for worsening osteoporosis?

2 Answers available

Is there a role for levothyroxine in managing the symptoms of a patient with euthyroid Hashimoto’s thyroiditis?

3 Answers available

Do you interpret failure to develop hypernatremia with prolonged water deprivation (such as for 12 hours) as evidence against diabetes insipidus even if the urine osmolality is just below normal?

For a patient whose sodium remains 142 despite water deprivation from 8 pm to 8 am, with urine osm of about 500, is further testing needed?

2 Answers available

Is there a role for use of GLP1 R agonist or dual agonist therapy for management of post bariatric hypoglycemia and dumping syndrome?

1 Answer available

How do you determine osteoporosis treatment response when patients have discrepant DEXA scan results during monitoring (eg improved BMD of the hip and spine but worsening BMD of the femoral neck)?

1 Answer available

How do you approach managing patients with diabetic kidney disease and proteinuria who develop hypoglycemia after initiation of a SGLT2 inhibitor?

1 Answer available

Do oral contraceptives lower bone mineral density in women with hypothalamic amenorrhea by lowering IGF-1?

1 Answer available

What treatment options would you consider for a young patient with limited mobility, low bone mass and multiple vertebral compression fractures who is on dialysis for advanced kidney disease?

1 Answer available

When and how should we be stopping GLP-1 Receptor Agonist/Dual Agonist therapy?

1 Answer available

Are thyroid molecular tests (such as Afirma, ThyroSeq) validated for use on FNA thyroid nodule samples that are not Bethesda class 3-4?

Clinical scenario where an indeterminate pathology on initial FNA was followed by a “benign” result on a 2nd FNA.

1 Answer available

How do you counsel patients on semaglutide or tirzepatide in light of potential cancer risks?

Do you avoid using these agents only in patients with history of medullary thyroid cancer or pancreatic cancer? Are there other cancer risks we should...

1 Answer available

Do you recommend progesterone for endometrial protection in a young woman on estrogen replacement therapy for iatrogenic menopause after definitive radiation therapy for locally advanced cervical cancer?

If so, what do you typically prescribe?

2 Answers available

How do you reduce the risk of contralateral fracture in a patient with atypical femur fracture from prolonged bisphosphonate use?

Do anabolic agents have a role?

1 Answer available

Do you recommend checking both TSI and TBII antibodies for Graves' disease diagnosis and monitoring?

1 Answer available

Do patients with central adrenal insufficiency on maintenance hydrocortisone therapy require doubling of their corticosteroid during chemotherapy cycles?

1 Answer available

Should we be using a cut off of 20 rather than the traditional 10 Hounsfield units to distinguish between benign and malignant adrenocortical tumors on imaging?

Viëtor et al., PMID 34503194

2 Answers available

How frequently do you monitor for hypocalcemia in patients on romosozumab?

1 Answer available

How do you medically manage uncontrolled Graves' disease in a patient awaiting surgery who is intolerant to methimazole and PTU and refusing RAI?

Patient had intolerance to methimazole and then developed agranulocytosis with PTU. FT4 is 2.9 (upper normal range is 1.7). I have started the patient...

1 Answer available

Would you consider using Evenity in an elderly patient with rate controlled atrial fibrillation without history of MI or CVA?

1 Answer available

Would you consider adding niacin to the lipid lowering regimen in statin-intolerant patients who cannot afford PCSK9i or bempedoic acid?

Ferrell et al., PMID 38448791

5 Answers available

What workup do you recommend for patients requiring higher-than-expected levothyroxine doses for their weight?

2 Answers available

What is the utility of near-infrared autofluorescence (NIRAF) imaging during parathyroid surgery?

2 Answers available

How often should TSH levels be monitored in patients with a history of Graves' disease who are in remission with negative TSI/TBII antibodies and off medical therapy?

1 Answer available

What clinical sign or symptom do you consider to be the most specific for Cushing syndrome?

1 Answer available

Is there any benefit of using aspirin to mitigate VTE risk in testosterone-induced polycythemia?

2 Answers available

How do you interpret the presence of GAD antibody in a middle-aged patient with diabetes when all other type 1 diabetes antibodies are absent?

2 Answers available

Do you recommend early oral nutrition when managing diabetic ketoacidosis?

Some data showed early enteral nutrition improves outcomes in DKA. Some thought that enteral nutrition could counteract the insulin gtt.

1 Answer available

When do you consider using setmelanotide for treatment of hypothalamic obesity?

2 Answers available

When discontinuing Denosumab after more than 2-3 years of therapy, when do you recommend giving the first dose of zoledronic acid?

2 Answers available

How do you counsel patients with elevated Thyroglobulin Peroxidase antibody levels, diffuse thyroiditis features on ultrasound, non-specific symptoms of fatigue, but normal biochemical thyroid function labs?

1 Answer available

Which patient population would most benefit from inhaled insulin (Afrezza)?

1 Answer available

What is the utility of checking reverse T3 in clinical practice?

2 Answers available

Do you recommend adding low-dose Aspirin for primary prevention in patients with Type 2 Diabetes on Eliquis for another indication?

1 Answer available

Can you explain the block and replace approach in the treatment of thyrotoxicosis, including when it is most appropriate to use and how it compares to other treatment options?

1 Answer available

What is the clinical significance of positive anti-thyroid antibodies in a patient that is post-thyroidectomy?

1 Answer available

Does oral semaglutide provide similar cardiovascular risk reduction benefits as injectable semaglutide?

1 Answer available

How do you approach mild prolactin elevations (20-80) in women with galactorrhea on nipple stimulation but regular menses and no plans for pregnancy?

1 Answer available

What strategies do you use to prevent overcorrection of serum sodium in patients with severe hyponatremia and adrenal insufficiency when initiating glucocorticoid therapy?

1 Answer available

Is there a role for using continuous glucose monitors for perioperative glucose monitoring in patients with diabetes?

1 Answer available

Is it necessary to prescribe a steroid taper after two weeks of high-dose prednisone (60 mg daily)?

4 Answers available

Do you recommend non-bypass bariatric surgeries over intestinal bypass procedures for kidney transplant-eligible candidates to prevent oxalate nephropathy, given the higher risk of kidney oxalate deposition with intestinal bypass?

2 Answers available

How do you manage osteoporosis treatment following parathyroidectomy for primary hyperparathyroidism?

1 Answer available

What is the upper limit of blood glucose target in hyperglycemic critically ill patients?

The new SCCM guidelines suggest an upper limit of 200 compared to the conventional 180.

1 Answer available

How should patients time the ingestion of their alendronate and levothyroxine given issues with food/drug interactions?

With the time intervals recommended after taking each medicine, I am wondering how patients should be counseled.

1 Answer available

Should all kidney transplant patients be started on statin therapy post operatively given their increased risk of CVD?

At what doses do you start? and how do you titrate therapy?

1 Answer available

Would you stop denosumab in a patient with chronic kidney disease if they develop asymptomatic hypocalcemia after the injection?

4 Answers available

Do you taper steroids more aggressively to decrease the risk of developing new-onset diabetes after transplantation in kidney transplant recipients who had pretransplant impaired fasting glucose?

2 Answers available

How soon after radioactive iodine therapy for hyperthyroidism should Methimazole be resumed?

1 Answer available

Would you consider treating empirically for AVP deficiency in a patient who had pituitary surgery 6 months earlier and complaints of polyuria/polydipsia with dilute urine (without performing water deprivation studies)?

2 Answers available

Would you consider PTH analogue in a patient with mildly elevated PTH?

2 Answers available

Does vitamin D supplementation in primary hyperparathyroidism increase the risk of kidney stones?

Is this seen more with high dose vitamin D supplementation?

1 Answer available

Have you been able to safely use other bisphosphonates in patients who developed an allergic reaction (angioedema) to fosamax?

1 Answer available

In ischemic stroke patients with low LDL levels (<30-50 mg/dl), would you consider lowering LDL levels to lower values without concern for any side effects?

How would you adjust statin therapy in these patients?

3 Answers available

What factors guide you in adjusting the dose of fludrocortisone in a patient with primary adrenal insufficiency?

1 Answer available

When should metformin be stopped before surgery and when is it considered safe to resume?

1 Answer available

Is there any evidence that spironolactone or finasteride therapy increase blood levels of testosterone?

2 Answers available

Do you recommend the use of Korlym (Mifepristone) for patients with difficult to control diabetes and evidence of mild endogenous hypercortisolism of unknown source?

1 Answer available

Do you recommend the use of bempedoic acid (Nexletol) for treatment of hyperlipidemia in patients with elevated baseline uric acid levels?

Should uric acid levels be monitored regularly while on therapy?

1 Answer available

Which brand/preparation of levothyroxine do you recommend to treat hypothyroid patients with alpha-gal allergy?

If they are already on a preparation that contains animal products, would you change it?

1 Answer available

How do you approach a young patient with metastatic poorly differentiated thyroid cancer with rhabdoid/non-anaplastic features?

4 Answers available

Would you discontinue romosozumab in a patient who develops a hemorrhagic stroke while on therapy?

5 Answers available

When do you recommend using trabecular bone score (TBS) for managing osteoporosis?

1 Answer available

When managing patients with suspected MASLD, what specific criteria or findings would prompt you to refer them to hepatology?

1 Answer available

What work up do you recommend in post bariatric surgery patients who are slowly gaining back the weight despite no changes in diet?

1 Answer available

Would you order a fibroscan to screen for MASLD in patients with insulin resistance but normal LFTs?

1 Answer available

How do you approach the use of GLP-1 receptor agonists for the management of patients with metabolically healthy obesity?

1 Answer available

Aside from adrenal insufficiency and thyroid toxicities, how do you approach other hormonal imbalances during treatment with immune checkpoint inhibitors?

Have you encountered changes in prolactin, testosterone, etc?

1 Answer available

Are recurrent UTIs a contraindication to SGLT2i use?

4 Answers available

Do you recommend parathyroid adenoma resection or ablation for patients with primary hyperparathyroidism and recurrent nephrolithiasis who are found to have a single gland adenoma on parathyroid ultrasound and nuclear medicine imaging?

1 Answer available

Do you recommend the use of GLP1 R agonist therapy in patients with T1DM for weight loss?

3 Answers available

When would you treat mild anemia from low testosterone in an older male?

Would you consider testosterone therapy if he is otherwise asymptomatic?

2 Answers available

What strategies do you employ for adjusting the dosage of levothyroxine in hypothyroid patients who experience significant weight loss or are initiated on GLP-1 receptor agonists?

How often do you recommend monitoring thyroid function tests in these situations?

1 Answer available

For patients with central hypothyroidism and a clear etiology (such as recent head irradiation), do you recommend brain imaging prior to starting thyroid hormone replacement therapy?

2 Answers available

Should low-intensity statins be favored to minimize the risk of diabetes onset while still offering cardiovascular benefit for patients with prediabetes where a statin is indicated?

Cholesterol Treatment Trialists' (CTT) Collaboration

2 Answers available

In your practice, when do you opt to treat unilateral primary hyperaldosteronism medically rather than surgically?

1 Answer available

When do you recommend screening patients with T2DM for heart failure?

2 Answers available

For patients with metabolic syndrome, is it reasonable to wait for the effect of tirzepatide therapy on their lipid profile prior to starting statin therapy?

4 Answers available

When do you recommend the use of oral testosterone replacement over injectable testosterone?

Ahmad et al., PMID 36106278

1 Answer available

What is the optimal anti androgen dose of spironolactone when treating female hirsutism?

1 Answer available

Are there any concerns with live vaccine innoculation and patients who are on denosumab?

1 Answer available

How long does it take the hypothalamic-pituitary-gonadal axis to recover from secondary amenorrhea in the setting early onset and chronic use of oral combined contraceptive pills?

1 Answer available

Do you recommend the use of automated insulin delivery systems (such as Control IQ with Tandem insulin pumps) for managing gestational diabetes?

1 Answer available

Is adequate BP control sufficient enough when titrating spironolactone therapy for primary hyperaldosteronism treatment?

2 Answers available

Do progesterone only oral contraceptive pills affect cortisol binding globulin?

1 Answer available

For hypothyroid patients on dual replacement therapy (levothyroxine & liothyronine), do you recommend monitoring TSH while holding off on the morning T3 dose?

3 Answers available

What 60 minute cortisol threshold value do you use for diagnosis of adrenal insufficiency after ACTH stimulation?

Zha et al., PMID 35487459

5 Answers available

What is your approach to management of hyperlipidemia in patients taking JAK inhibitors?

1 Answer available

How do you counsel patients on the use of compounded weight loss medications?

3 Answers available

What factors aside from progression do you consider most important in determining whether a patient with metastatic papillary thyroid carcinoma is radioactive iodine refractory?

What is your evaluation approach for RAI response? What cumulative dose do you use in practice for deciding a patient is RAI refractory?

1 Answer available

Which fracture sites outside of the classical spine and hip are considered to be osteoporotic fractures even in the absence of a bone density diagnosis?

2 Answers available

How does contralateral suppression of more than 50% with cosyntropin during adrenal venous sampling influence your decision to recommend adrenalectomy in patients with primary aldosteronism?

Okubo et al., PMID 38442744

1 Answer available

Would you recommend changing a patient from the pill form of levothyroxine to Tirosint-SOL if they are started on a proton pump inhibitor?

Yue et al., PMID 38554774

1 Answer available

Do you use absolute random cortisol levels or delta cortisol levels after ACTH stimulation to diagnose adrenal insufficiency in the critically ill?

2 Answers available

What work up do you recommend for persistent subclinical hyperthyroidism with decreased RAI uptake and negative thyroid antibody tests?

1 Answer available

How do you approach a patient with elevated bone specific ALP (>2X the normal limit), but no other evidence of Paget's disease?

Normal Vitamin D, bone scan showed osteoarthritis

1 Answer available

Which patients would benefit most from teplizumab therapy to delay the onset of T1DM?

Herold et al., PMID 31180194

2 Answers available

Do you recommend the use of GLP 1 R agonist therapy for obese women with PCOS who are actively trying to conceive?

Dao et al., PMID 38663923

2 Answers available

What are the treatment options for severe recurrent hypoglycemia in a patient with malignant insulinoma?

Trial has included diazoxide, decadron, verapamil and pasireotide with ongoing overnight lows.

1 Answer available

Do you recommend a particular antiresorptive/anabolic agent for patients who are at high risk for fractures but have high risk of osteonecrosis of the jaw?

3 Answers available

Would you recommend cinacalcet for patients with recurrent nephrolithiasis who have hypercalciuria despite thiazide diuretic use and who also have an elevated PTH level without localizing parathyroid adenoma on imaging?

1 Answer available

What is the typical timeline for remission of autoimmune hypoglycemia?

1 Answer available

What is the clinical importance of differentiating between impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) states?

Bergman et al., PMID 38458916

2 Answers available

What evaluation do you do in patients with hypertension and persistently elevated aldosterone/renin ratio (over 20) but without an elevated aldosterone level (under 10 ng/dL)?

1 Answer available

Is Metformin contraindicated in patients using long term oxygen therapy at home?

Liang et al., PMID 35900801

1 Answer available

How do you adjust your management strategy to address the unique needs of anuric end-stage kidney disease patients when treating diabetic ketoacidosis?

1 Answer available

What are the indications for use of inclisiran over anti-PCSK9 monoclonal antibody therapies?

2 Answers available

Is a history of provoked DVT a contraindication to starting testosterone replacement therapy in a middle aged man with symptomatic hypogonadism who is on anti-coagulation?

1 Answer available

How do you choose between antithyroid drugs, RAI, and surgery for hyperthyroidism patients with existing cardiovascular disease, given their varying effects on cardiovascular outcomes?

Chiung-Hui Peng et al., PMID 38436957

3 Answers available

In obese men presenting with gynecomastia, elevated estrogens, and hypogonadism, what clinical factors would push you to obtain testicular and/or adrenal imaging to rule out an estrogen-producing tumor?

Do you base the decision off of the acuity and course of symptoms? The degree of estradiol elevation? Other factors?

1 Answer available

Is there any contraindication for use of Invisalign teeth aligners in patients undergoing treatment for osteoporosis?

Do treatments for osteoporosis have a large enough effect on tooth movement to make Invisalign less effective?

1 Answer available

Do you adjust the dose or the timing of levothyroxine ingestion in patients on anti-acid medications?

2 Answers available

How would you counsel a female to male transgender patient regarding VTE risk with testosterone therapy, who has additional mild-moderate risk factors for thrombosis?

Additional risk factors could be family history of VTE or thrombophilia, such as antithrombin deficiency.

1 Answer available

Would you transition from denosumab to anabolic agents in patients who are in urgent need for extensive dental work?

2 Answers available

Is active smoking a contraindication to starting menopausal hormone therapy (HRT) in a post-menopausal woman with severe vasomotor symptoms and no other cardiovascular risk factors?

1 Answer available

Should fasting C-peptide levels be used to guide T2DM management?

2 Answers available

Given the cardioprotective and renoprotective effects of SGLT2 inhibitors, should we consider administering to patients with well controlled type 1 diabetes despite the risk of DKA?

3 Answers available

What is your approach to a patient on long-term denosumab who now requires multiple invasive dental procedures?

2 Answers available

Do you recommend using anastrazole in men developing gynecomastia while on testosterone replacement treatment for hypogonadism depending on pre-treatment estradiol level?

1 Answer available

Do you delay spinal surgery (e.g. lumbar decompression for stenosis) in men or women with newly diagnosed osteoporosis and multiple thoracic compression fractures (not involving site of potential surgery) in order to initiate anabolic or anti-resorptive therapy to potentially improve surgical healing outcomes?

2 Answers available

Do you recommend stopping a SGLT2i indefinitely if a patient with chronic kidney disease and diabetes develops euglycemic diabetic ketoacidosis?

1 Answer available

Do you recommend parathyroid imaging testing for patients with recurrent nephrolithiasis who are incidentally found to have an elevated PTH but who do not have hypercalciuria, hypercalcemia, hypovitaminosis D, or chronic kidney disease?

2 Answers available

Do you use the homeostatic model assessment (HOMA) to assess for insulin resistance and change your clinical management of patients?

3 Answers available

What is your approach to managing patients with recurrent nephrolithiasis and nephrocalcinosis in the setting of hypoparathyroidism?

1 Answer available

Would you add cholecalciferol or ergocalciferol to calcitriol therapy in patients with post operative hypoparathyroidism who have low 25 OH vitamin D levels?

Can 25 OH vitamin D be converted to activated vitamin D outside of PTH mediated mechanisms in some organs?

2 Answers available

For a patient with idiopathic hypercalciuria and a history of calcium kidney stones who has not normalized 24-hr urine calcium level on thiazide diuretic, is there evidence for targeting a certain urine calcium level for decreased future risk of nephrolithiasis and osteoporosis?

2 Answers available

When performing adrenal vein sampling, is calculating selectivity index using androstenedione superior to using cortisol alone for determining successful catheterization?

1 Answer available

What is your approach to progressive calvarial hyperostosis found in an elderly adult not caused by Pagets, acromegaly or hypercalcemia?

No evidence for acromegaly or Pagets.

1 Answer available

Given the risk of hypocalcemia in dialysis dependent patients treated with denosumab, what is the best method of treatment for osteoporosis for these patients, and should we be transitioning to a different agent?

2 Answers available

Does your decision to start or continue Ozempic therapy in patients with diabetic retinopathy depend on the severity of the retinopathy?

1 Answer available

Do you prioritize dietary modifications and exercise over early pharmacologic interventions, such as metformin or insulin, for women diagnosed with gestational diabetes?

1 Answer available

Should dopamine agonist treatment stop in pregnant patients with recurrent prolactinoma despite prior surgery?

1 Answer available

What specific clinical factors would drive you to recommend surgical intervention for patients with small, nonfunctional pituitary adenomas who exhibit no neurological symptoms?

1 Answer available

When and how do you taper off cabergoline therapy for treatment of microprolactinoma?

1 Answer available

What is your approach to managing patients with new laboratory evidence of hypopituitarism (e.g. very low plasma ACTH level and low morning serum cortisol) and a remote history of trans-sphenoidal surgery for NFPA?

1 Answer available

Should GLP1 R agonists be used as first line glucose lowering agents in patients with ESKD and DM2?

1 Answer available

In patients presenting with classical findings of primary hyperparathyroidism (i.e mild hypercalcemia, high 24hr urine calcium, elevated 1,25 Vit D but normal PTH), can spontaneous normalization of calcium be explained by episodic hypersecretion of PTH?

1 Answer available

Under what circumstances would you test for hypercortisolism in a patient with insulin resistance?

1 Answer available

Does growth hormone (GH) replacement therapy reduce the risk of fractures in patients with GH deficiency?

1 Answer available

Do you routinely use anti-resorptive medications in patients who have osteoporosis and longstanding hypoparathyroidism?

1 Answer available

What are the clinical indications and major limitations of lipoprotein apheresis?

2 Answers available

How reliable is the FRAX score for assessing risk of osteoporotic fractures?

1 Answer available

Is there any role for 25-OH Vitamin D testing in patients older than 75 years old in the general population?

Demay, et al., PMID 38828931

2 Answers available

Does biotin interfere with the measurement of other metabolites of the Vitamin D pathway outside of the 25-hydroxy Vitamin D assay?

1 Answer available

Do you avoid empagliflozin in patients with history of amputation?

We know canagliflozin is not given to patients with amputations, what about other SGLT2 inhibitors

1 Answer available

How would you approach a finding of osteoporosis (Z score -4.5) in a recently postpartum patient who had DEXA sent for long-term low-dose glucocorticoid use?

The patient is actively breastfeeding.

1 Answer available

Are you offering GLP-1 agonists to patients with CKD and diabetes mellitus?

4 Answers available

Do you recommend Alpha Lipoic Acid to patients with diabetic polyneuropathy?

6 Answers available

Is there any evidence regarding bone density gains/fracture reduction in the setting of treatment with romosozumab after a two year course of teriparatide?

Many patients are interested in romosozumab for "maximizing bone gain" and preventing future fractures. Some have had anabolic therapy with teriparati...

1 Answer available

Which screening method for diabetes do you consider to be the most sensitive?

Bergman et al., PMID 38458916

1 Answer available

What is the utility of an oral calcium loading test to differentiate FHH from secondary hyperparathyroidism due to low calcium intake?

The patient has very low urinary calcium despite calcium supplements, vitamin D used to be low now normal. Continues to have elevated PTH with normal ...

2 Answers available

Do you recommend continuous glucose monitoring for patients with Type 2 diabetes who are not on insulin?

5 Answers available

Should weight loss medications be used in women who are gaining excessive weight during pregnancy?

1 Answer available

What range of musculoskeletal complaints have you seen with romosozumab use?

1 Answer available

What work-up should be considered in patients with significantly worsening A1c despite steady diet, lifestyle, and medication adherence?

1 Answer available

Is dosimetry more important than preparation (ie rhTSH versus THW) when treating thyroid cancer with radioactive iodine therapy?

1 Answer available

What specific markers or symptoms guide your decision to adjust or stop prophylactic calcium supplementation and calcitriol in managing postoperative hypoparathyroidism following thyroidectomy?

1 Answer available

Would you consider exploratory surgery in a young patient with normocalcemic hyperparathyroidism that meets one or more criteria for parathyroidectomy but has no localized pathology on advanced neck imaging?

1 Answer available

In what clinical scenarios should we use the 2-day 2mg DST instead of the 1mg overnight DST for screening of Cushing syndrome?

1 Answer available

What endocrine therapy would you recommend to a premenopausal female with early stage HR+ Breast cancer who is transitioning from female to male and currently on testosterone?

1 Answer available

Should all thyroid cancer patients have thyroglobulin levels measured pre-operatively?

2 Answers available

Is ABI (Ankle Brachial index) lower limb arterial doppler not recommended if patient already has arterial stents in the legs, and if so, what other imaging modality would you consider as first-line?

1 Answer available

Should serum calcitonin for surveillance of medullary thyroid cancer be done fasting ?

1 Answer available

Is Macrilen (macimorelin Dx) still available in the US for diagnosis of adult growth hormone deficiency (AGHD)?

1 Answer available

When and for whom should we consider adding bempedoic acid to the lipid lowering regimen?

3 Answers available

Do you recommend obtaining a DEXA scan for patients with recurrent nephrolithiasis and hypercalciuria of unknown etiology?

2 Answers available

What is your approach to differentiating primary from secondary hyperparathyroidism in recurrent kidney stone formers who also have chronic kidney disease, an elevated PTH, and hypercalcemia?

1 Answer available

Should patients with non-functional pituitary macroadenomas with persistent, but tolerable, headaches be recommended for surgery?

1 Answer available

Given the new 2022 WHO classification of pituitary tumors, should we be regularly counseling our patients about the risk of malignancy for what we previously referred to as pituitary adenomas but now classified as pituitary neuroendocrine tumors (PitNETs)?

Asa et al., PMID 35291028

1 Answer available

What is your approach to differentiating diabetes insipidus from primary polydipsia in the outpatient setting?

1 Answer available

In patients with hypertension and suspected primary aldosteronism who have undergone negative confirmatory testing, what follow-up and monitoring strategies would you recommend to ensure early detection of potential aldosteronism?

1 Answer available

Do you routinely check a TSH level in patients with recurrent kidney stones who have hypercalciuria of unknown cause?

1 Answer available

Which patient population would benefit most from cellulose and citric acid (Plenity) therapy for weight loss?

1 Answer available

Has your management of severe hyponatremia changed after a recent observational study described higher in-hospital mortality for sodium correction of <6 mEq/L compared to 6-10 mEq/L in the first 24 hours?

Seethapathy et al., NEJM

5 Answers available

What is your approach to managing osteoporosis in patients with end stage kidney disease?

1 Answer available

Would you consider GLP1 R agonist therapy in a patient with a history of severe gallstone pancreatitis that is now post cholecystectomy?

1 Answer available

Does preoperative use of somatostatin receptor ligand improve remission rates after surgery for acromegaly?

1 Answer available

What is the goal of estradiol levels on ovarian suppression and AI for breast cancer?

Would you recommend aiming for the postmenopausal range as per the lab reference range or do you have a specific goal?

1 Answer available

How do you time Evenity after completion of Forteo?

1 Answer available

What is your approach to determining recurrent versus RAI-refractory differentiated thyroid cancer in patients presenting with metastatic disease several years after surgery?

1 Answer available

How do you adjust your HbA1c goal for managing diabetes in elderly patients with multiple chronic illnesses but no limitations in performing self-care tasks?

1 Answer available

In SIADH due to malignancy, do you prefer to use free water restriction or salt tablets?

Or other therapy - e.g., tolvaptan? Free water restriction may hinder QOL. Salt tablets may raise levels more quickly but have risks of edema and hype...

1 Answer available

What is the role of radiation therapy for an elderly patient with medullary thyroid cancer who is not a surgical candidate?

What techniques and doses would you prescribe to the primary and regional nodes?

1 Answer available

Would you use romosozumab in a patient with a cardiovascular event more than 2 years prior?

4 Answers available

Would you refer a patient for parathyroidectomy if they have normal calcium levels, mild hyperparathyroidism, and evidence of osteopenia?

2 Answers available

Do you use denosumab for castration-sensitive prostate cancer with osseous metastases?

Only the mCRPC population was included in the Fizazi et al. study, but the FDA approval is for prevention of skeletal related events from any solid tu...

4 Answers available

Do you recommend osteoporosis medication in postmenopausal females on anastrozole with very low Vitamin D (4.5)?

After replacing Vitamin D, what will be your first treatment of choice? Labs including ALP and calcium levels are normal. T scores are -3 or above. Th...

1 Answer available

How do you counsel patients with non-statin associated inflammatory myopathies about statin use?

1 Answer available

When would you offer post-operative concurrent chemoradiation in anaplastic thyroid cancer?

Would you consider it for a patient with good PS but with limited metastatic disease? What dose fractionation would you prefer?

1 Answer available

Is there a role for cinacalcet suppression testing when evaluating patients for suspected primary hyperparathyroidism who also have recurrent calcium containing kidney stone disease?

1 Answer available

When do you check macroprolactin in the evaluation of hyperprolactinemia?

2 Answers available

Following abaloparatide use for osteoporosis treatment, how long do you consolidate with bisphosphonates before considering a drug holiday?

1 Answer available

Do you routinely use 3% sodium chloride and desmopressin to correct hypovolemic hyponatremia in an asymptomatic patient with serum sodium of less than 120 mEq/L?

3 Answers available

Should patients with hypothyroidism hold their morning levothyroxine dose before going to the lab to check free T4/TSH?

There is literature showing small changes in both free T4 and TSH (despite steady state) in the first few hours after ingestion of L-T4. In occasional...

3 Answers available

Is there a role for Vitamin D supplementation in the treatment of Hashimoto’s thyroiditis?

1 Answer available

After completing 12 months romosozumab, what is the next best treatment option for patients with severe osteoporosis, high risk for fracture, and normal kidney function?

1 Answer available

How do you monitor risk of erythrocytosis from testosterone use for female to male transgender patients?

1 Answer available

Would you do active surveillance or completion thyroidectomy in a patient with 1.6 cm tall cell PTC with posterior margin’s indeterminate and 7 mm isoechoic solid nodule on other side?

Patient is a 41F and overall good surgical risk candidate.

1 Answer available

How do you counsel a patient with hypothyroidism who complains of persistent hypothyroid symptoms despite achieving normal TSH values with levothyroxine?

1 Answer available

Should patients who develop primary hyperparathyroidism after 5 years of Prolia treatment for osteoporosis be referred for parathyroidectomy?

If so, when? Does surgery need to be timed with last dose of Prolia injection?

1 Answer available

How do you distinguish between primary and tertiary hyperparathyroidism in a patient with ESRD?

1 Answer available

Does norethindrone suppress FSH, LH completely?

If not, what can be possible causes for a postmenopausal woman to have FSH, LH < 0.3 with low E2, and being asymptomatic and doing well otherwise? ...

2 Answers available

What is your daily correction goal for those patients being treated for hypernatremia?

2 Answers available

Would you consider anabolic osteoporosis therapy in a young adult male with multiple non-traumatic vertebral compression fractures and low bone density for age (Z-score -2.6)?

A male patient in his 30s with two lumbar compression fractures (non-traumatic) and a Z-score of -2.6 in the spine, Z-score -0.5 in hips. History of 3...

1 Answer available

Can romosozumab be used in patients on dialysis?

1 Answer available

When do you consider stopping denosumab when a patient with osteoporosis is otherwise tolerating it without issues?

Assuming follow-up IV bisphosphonate x2 infusions to prevent rebound fractures

5 Answers available

Would you recommend switching a diabetic CKD patient on oral semaglutide to the subcutaneous form since the benefits in CKD have primarily been reported in studies using subcutaneous GLP-1 receptor agonists?

1 Answer available

How long do you wait before reassessing a 24 hour urine calcium level in patients with recurrent nephrolithiasis, hypercalciuria, and osteoporosis who are initiated on bisphosphonate therapy?

3 Answers available

Under what circumstances would you refer a patient with mild autonomous cortisol secretion without features of Cushing syndrome for adrenalectomy?

1 Answer available

What is the next step in management of a thyroid nodule that was biopsied and classified as Bethesda III, but Afirma genetic testing reveals parathyroid signature?

Patient does not have hypercalcemia.

2 Answers available

Should Orlistat be considered in the management of hypertriglyceridemia?

1 Answer available

Do patients with an elevated IGF-1 level and features of acromegaly need to have confirmatory growth hormone suppression testing with OGTT?

Can a diagnosis of acromegaly be made with just an elevated IGF-1 level in patients with features of acromegaly?

2 Answers available

What is your approach to treating osteoporosis in patients post bariatric surgery?

Are oral bisphosphonates contraindicated with all types of bariatric procedures?

3 Answers available

Is intermittent fasting effective for weight loss?

3 Answers available

In a patient with low-risk papillary thyroid carcinoma in 1 thyroid lobe s/p hemithyroidectomy, how would a diagnosis of Graves' orbitopathy (euthyroid biochemically) affect your classification and TSH target for thyroid-cancer treatment?

Conflicting data exists on whether Graves' disease would increase the aggressiveness of the concomitant thyroid cancer vs having no effect/correlation...

1 Answer available

Would you treat an isolated elevated total cholesterol in a post-menopausal patient who is otherwise healthy and has no significant CV risk factors?

2 Answers available

When do you refer a patient with MODY3 to GI/Hepatology for monitoring/management of hepatic adenomas?

1 Answer available

Can anabolic agents be used in a patient with history of radioactive iodine treatment for hyperthyroidism?

1 Answer available

Would you switch a patient with glucocorticoid induced osteoporosis to romosozumab if a patient sustained a fragility fracture 1 year into treatment with teriparatide?

1 Answer available

How long should T3 be continued in hypothyroid patients who received no symptomatic benefit after starting T3/T4 combination therapy?

2 Answers available

What is your approach to a patient with a low alkaline phosphatase?

What level or additional signs/symptoms trigger a workup? What does your workup typically consist of?

5 Answers available

Would you give a second round of therapeutic RAI in a patient with PTC s/p total thyroidectomy and I-131 ablation who is found to have recurrent disease in cervical lymph nodes s/p repeat neck dissection?

What dose of RAI would you consider giving if recommended?

2 Answers available

Do you treat hypercalciuria in post menopausal osteoporosis with normal serum calcium and PTH?

2 Answers available

Aside from lifestyle measures such as calcium intake, vitamin D repletion, and weight-bearing exercises and ruling out all secondary causes, what is the preferred approach to managing osteoporosis in young women with Z score of less than -2.5 and planning to get pregnant soon?

2 Answers available

When do you start bisphosphonates empirically, irrespective of DEXA results, in patients going on chronic glucocorticoids?

1 Answer available

Should thyroid hormone replacement be initiated in patients with very prolonged critical illness with associated low thyroid hormone levels?

1 Answer available

Is thyrotropin receptor antibody a good biomarker to predict development of thyroid eye disease?

1 Answer available

Where do you place romosozumab in your treatment sequence for osteoporosis management?

4 Answers available

What are the potential causes for significant discrepancies between predicted A1c by Dexcom CGM and standard serum A1c by lab draw?

I have a longstanding patient with diabetes and a consistently significant difference between CGM average and that predicted by serum A1c. The CGM avg...

1 Answer available

Is history of radiation an absolute contraindication to using parathyroid hormone (PTH) analogues?

Does it depend on location of radiation, length of radiation, and time since radiation?

3 Answers available

Should oral combined contraceptives be held prior to overnight dexamethasone suppression test to rule out Cushings?

If so, how long should OCPs be held to reliably trust the dex suppression test results?

2 Answers available

Can combined oral contraceptive use cause falsely elevated 24-hour urine-free cortisol?

2 Answers available

Is there enough evidence now to use injectable semaglutide as a foundational therapy for symptomatic heart failure with preserved ejection fraction in the setting of overweight or obesity?

1 Answer available

In patients with secondary osteoporosis due to primary hyperparathyroidism, should parathyroidectomy be recommended in the setting of recent prior bisphosphonate use?

1 Answer available

How do you approach a patient with biochemical evidence of primary hyperparathyroidism, but normal parathyroid scan?

4 Answers available

Should testosterone replacement be stopped in elderly men who suffered acute stroke even when testosterone levels have been stably in the low-to-mid normal range?

1 Answer available

Would you recommend prescribing testosterone replacement therapy to reduce osteoporosis fracture rates in men with hypogonadism?

1 Answer available

What is your protocol to starting/stopping glucocorticoid replacement in Cushing disease patients after their transsphenoidal resection surgery?

1 Answer available

Have the results of the ancillary study of the VITAL trial, demonstrating that Vitamin D3 supplementation did not reduce the incident rate of fractures in generally healthy midlife and older adults, changed how you prescribe Vitamin D?

PMID 35939577

2 Answers available

How would you approach choosing osteoporosis treatment in a patient with a T score -3.3 in lumbar spine and no prior fracture history who has squamous cell cancer and received radiation therapy?

1 Answer available

How do you manage osteoporosis in patients with anorexia nervosa (who often are young women < 40)?

2 Answers available

Should metformin be used in women with PCOS for weight loss?

1 Answer available

Should patients with mild subclinical hypothyroidism (TSH < 10 mIU/L) be treated with thyroid hormone replacement to improve their lipid profile?

2 Answers available

Is it possible to have undetectable cortisol levels in secondary adrenal insufficiency?

Young, previously healthy male with normal growth presenting with two syncopal episodes. Currently, only symptom is mild fatigue. Labs showed: Cortiso...

2 Answers available

What is your approach to using bisphosphonates in those with severe hypercalcemia and chronic kidney disease?

1 Answer available

How often would you repeat testing in a patient suspected of Cyclic Cushing's?

And is there a preferred diagnostic test? Whenever cyclic hypercortisolemia is suspected, it is advised that evaluation should be repeated for months,...

2 Answers available

Do you recommend continuing SGLT2 inhibitors in patients with diabetic kidney disease and congestive heart failure who have been taking the medication for several years and later develop end stage kidney disease?

3 Answers available

What would be your next step in treating a patient with osteoporosis who developed AFF on denosumab and who then completed one year of romosozumab?

3 Answers available

Is it possible for certain individuals with osteoporosis to be a denosumab "non-responder"?

I’ve seen several such patients who have no secondary causes for bone loss, on adequate calcium/vitamin D, and compliant with denosumab who do n...

1 Answer available

Can joint replacement surgery be performed in someone with active Paget’s disease elsewhere?

1 Answer available

What further work-up (if any) should be considered in patients with pituitary microadenoma and stigmata of Cushing's disease but low ACTH and repeatedly normal plasma, urinary, and salivary cortisol levels?

1 Answer available

For a patient with osteopenia or osteoporosis, how long can intravenous zoledronic acid be maintained if there are not adverse events?

1 Answer available

What is the differential for elevated T3 (with suppressed T4 and normal TSH) in a patient not taking any thyroid hormones?

Female is in her later 40s with surgical oophorectomy taking Sertraline 50 mg daily and prn Trazodone and Lamotrigine. Has some weight loss and fatigu...

1 Answer available

What is your approach to tapering chronic steroids in patients who are at high risk of HPA suppression?

For example, patients who have been maintained on 5mg of prednisone for years without previous tapering attempts and the rheumatic disease is not acti...

1 Answer available

Is there an indication for adrenalectomy in patients with subclinical Cushing syndrome and adrenal nodule?

1 Answer available

Should lipid lowering therapy be started in patients with isolated elevation in lipoprotein (a) and minimal cardiovascular risk?

2 Answers available

Despite low T scores (-2.5 or worse), what is the actual fracture risk in relatively younger patients (early 50s to mid 60s) with low BMD?

Should this patient population be treated differently? At our institution, we have started using EPIC to screen many patients for osteoporosis and ou...

1 Answer available

Would you start osteoporosis treatment in patients with low FRAX scores but have T scores lower than -2.5?

1 Answer available

What is the best treatment of isolated elevated DHEA-S in a woman with clinical androgen excess (without PCOS, neoplasm, etc)?

1 Answer available

When would you offer radiation for poorly differentiated thyroid cancer?

3 Answers available

What is the rationale behind the Anesthesiology recommendation to hold one dose of weekly GLP-RA prior to general anesthesia?

There is a current recommendation from the anesthesia society to hold one dose of GLP-RA prior to general anesthesia. Given the long half-life of the ...

1 Answer available

How do you counsel cancer patients when they ask if they should avoid sugar?

9 Answers available

For a TSH producing microadenoma, would you recommend surgery vs methimazole if the patient is elderly and the tumor is relatively small?

The female patient is in her late 70s with cardiac disease (likely due to chronic hyperthyroidism that was missed due to non-suppressed TSH). I’...

1 Answer available

Would you order a DEXA scan for a cervical cancer patient with osteoporosis?

NCCN cervical cancer guidelines added a new statement - Patients who have received prior pelvic radiation therapy and have osteoporosis may benef...

1 Answer available

Should insulin be started early (prior to optimization of other anti-hyperglycemic medications) in patients with mild-to-moderate diabetes and hypertriglyceridemia refractory to statin and fibrates?

2 Answers available

Should thyroxine hormone be started in women having fertility concerns with high-normal TSH and negative TPO antibody?

2 Answers available

Would atypical fractures of the hip in a parent (treated with bisphosphonate) be considered when calculating the FRAX score for a patient with osteopenia?

2 Answers available

How should very low T scores (worse than -3) be interpreted in very thin patients (BMI < 18)?

1 Answer available

Can subclinical hypothyroidism cause myxedema coma?

Elderly male with primary hypothyroidism, HTN, and progressive worsening cognition over several months. PCP has been increasing LT4 dose as outpatient...

2 Answers available

In adult women with NCCAH, is there a benefit in using supratherapeutic doses of prednisone in addition to clomiphene to improve fertility rates?

1 Answer available

Should GLP-1 agonists be weaned in patients who have achieved goal weight loss and glycemic control?

1 Answer available

Which medications do you deem necessary to stop prior to measuring plasma renin and plasma aldosterone when evaluating a patient for possible primary aldosteronism?

1 Answer available

Would you give transdermal hormone replacement therapy to a woman with remote history of provoked pulmonary embolism?

Is patch or gel HRT with ASA prophylaxis a reasonable option after counseling? Or do you add a prophylactic DOAC?

1 Answer available

Should a short trial of androgen therapy be used in patients with primary adrenal insufficiency suffering from persistent fatigue and hypoactive sexual desire despite sufficient glucocorticoid and mineralocorticoid replacement?

1 Answer available

What is the next best anti-hypertensive medication to start after mineralocorticoid receptor antagonists in patients with primary aldosteronism?

1 Answer available

What is your preferred method for confirming the diagnosis of primary aldosteronism in a patient with an elevated plasma aldosterone to renin ratio?

1 Answer available

Is there any indication for obtaining adrenal imaging in patients with MEN2 who have normal plasma or urinary metanephrines?

1 Answer available

How do you manage calcium and vitamin D replacement in scleroderma and myositis patients with dysphagia and malabsorption?

1 Answer available

What is your approach to treating premenopausal woman with OI with a new compression fracture?

2 Answers available

Should patients with asymptomatic GH deficiency be treated with GH replacement therapy if they have prior known severe CAD?

1 Answer available

Does caution have to be used in GH replacement therapy in any and all types of cancer history?

1 Answer available

Is a significant rise in cortisol post cosyntropin stimulation sufficient to rule out adrenal insufficiency in patients with low albumin?

1 Answer available

Can osilodrostat be used indefinitely in poor surgical candidates with cushing syndrome from adrenal adenoma?

1 Answer available

Does your goal rate of correction in patients with chronic hypoosmolar hyponatremia differ based on the degree of hypoosmolarity?

4 Answers available

Should a toe-brachial index be obtained in lieu of resting ABI as an initial screen for PAD in high-risk patients such as those with longstanding diabetes or advanced age with stiffened vessels?

1 Answer available

What treatment would you use in a patient with osteoporosis on denosumab for 10 years who develops ONJ at a site of an old implant?

1 Answer available

In a young female with severe osteoporosis due to congenital estrogen deficiency, can estrogen be prescribed if genetic testing for congenital disorders reveals a heterozygous Factor V Leiden mutation?

No prior thrombosis; no family history of thrombosis. As per endocrine, the only useful therapy for the osteoporosis is estrogen.

1 Answer available

How do you approach long term management of glucocorticoid-induced osteoporosis in patients who develop osteonecrosis of the jaw on antiresorptive agent?

2 Answers available

Are there contraindications to growth hormone therapy in patients who have completed treatment for pediatric cancer?

1 Answer available

Do you recommend stopping Vitamin D supplementation in a patient with hypercalcemia and a low 25(OH)D level?

1 Answer available

When tapering moderate to high doses of long term steroids do you routinely monitor for adrenal insufficiency?

Do you attempt to taper fully or maintain at a low dose?

2 Answers available

Are there any concerns regarding side effects in changing from denosumab to zolendronic acid or vice versa?

1 Answer available

How would you manage a patient with osteoporosis on denosumab who develops significant renal insufficiency where it is difficult to continue denosumab due to increased risk of hypocalcemia (i.e. eGFR in the low 20’s)?

1 Answer available

In which patients with chronic kidney disease and low 25-OH vitamin D levels do you prefer weekly ergocalciferol to daily cholecalciferol supplementation?

1 Answer available

Do you treat low 25-OH vitamin D levels in those with end stage kidney disease?

1 Answer available

In a patient with bisphosphonate induced bilateral atypical femur fractures, how would you approach timing of alternative osteoporosis treatments and surgical management?

2 Answers available

What kinds of dental work do you particularly worry about and try to avoid in patients on bisphosphonates?

2 Answers available

What is your approach to managing hypocalcemia following a parathyroidectomy in patients with end stage kidney disease?

1 Answer available

In a patient who fractures after several years of denosumab therapy, would you wait 6 months after the last denosumab injection to start an anabolic agent or could start an anabolic agent sooner?

1 Answer available

Would you avoid the entire class of bisphosphonates if a patient develops an allergic reaction, or would you consider the use of an alternative bisphosphonate?

2 Answers available

Can denosumab be given every 3 months?

With studies showing non inferiority to zoledronic acid q 3 months in support of bone metastatic disease, would you consider extrapolating this data a...

1 Answer available

When treating patients with immune checkpoint inhibitors, do you routinely check markers of endocrinopathies such as TSH/ACTH, or only when a patient has symptoms?

If so, how often do you check these labs?

1 Answer available

For a patient who would benefit from an anabolic agent for osteoporosis, do you prefer romosuzumab over teriparatide in the absence of contraindications to either agent?

3 Answers available

How do you approach a potential drug holiday in a patient with osteoporosis who has had improvement in BMD after several years of denosumab therapy?

1 Answer available

Do you initiate management of new onset diabetes in a patient on immunotherapy or refer immediately to endocrinology given the risk of rapid worsening?

1 Answer available

How do you approach treatment of osteoporosis in patients with CKD who develop a fragility fracture while on denosumab?

1 Answer available

Do you treat secondary erythrocytosis caused by SGLT2 inhibitor?

1 Answer available

Is history of radiation therapy for uterine cancer an absolute contraindication to parathyroid hormone/parathyroid hormone related protein analogues such as teriparatide and abaloparatide in a patient with severe osteoporosis with multiple spine fractures?

2 Answers available

How do you plan to use adjuvant denosumab in patients with hormone positive breast cancer given the survival advantage seen in the ABCSG-18 trial?

Do you look into their stage/risk to decide? Since patients can experience bone loss after stopping denosumab, how do you plan to discontinue?

1 Answer available

What recommendations do you have for a transgender female patient with history of prothrombin gene mutation who is interested in starting gender affirming hormone therapy?

The patient has no personal history of VTE, but has positive family history of VTE. Any prophylactic anticoagulation options? How would manage...

1 Answer available

What dose/fractionation would you use to treat a papillary thyroid cancer with bulky cervical adenopathy and laryngeal invasion with impending airway obstruction that is refusing laryngectomy and surgical management?

1 Answer available

In a patient who completed 5 years of oral bisphosphonate and has a T score persistently in osteoporotic range, what factors help you decide whether it is appropriate to start a drug holiday vs. switch to an alternative agent?

1 Answer available

Do you change management in patients that are taking bisphosphonates and develop atrial fibrillation?

1 Answer available

In postmenopausal osteoporosis, would you switch to romosozumab (rather than a PTH/PTHrP analog) if a patient fractures while on denosumab?

1 Answer available

How do you approach the use of bisphosphonates in reproductive-aged women?

1 Answer available

How long after the presentation of Graves ophthalmopathy is orbital radiotherapy helpful?

If a patient has been treated sucessfully for Graves but has persistent symptoms of diplopia, is radiation therapy helpful? Or is this just a dry and ...

1 Answer available

What is your approach to adjuvant hormone therapy for HR+ breast cancer in post-menopausal women with pre-existing osteoporosis?

Would you consider omitting treatment if small tumor and early stage? Or would you use tamoxifen?

2 Answers available

Would you consider using teriparatide beyond a cumulative maximum of two years now that the black box warning regarding osteosarcoma has been removed?

1 Answer available

For someone with asymmetric Graves ophthalmopathy, do you still treat both eyes, or target the single affected orbit?

1 Answer available

Do you offer adjuvant bisphosphonates to high-risk premenopausal women on ovarian suppression for early-stage breast cancer who would want to consider pregnancy in the future?

Which agents would you select and for how long would you treat them?

1 Answer available

For patients with mild CKD, how do you decide between zoledronic acid and denosumab for bone protection in patients with multiple myeloma?

For pts w/ eGFR between 30-60

1 Answer available

How do you incorporate denosumab into the surgical management of giant cell tumor of bone?

Does the degree of resectability affect your management?

2 Answers available

How do you counsel patients about the risk of osteonecrosis of the jaw with anabolic agents such as teriparatide or romosozumab ?

Would you hold these agents in the setting of invasive dental procedures?

1 Answer available

What strategy do you use to determine the appropriate timing to resume osteoporosis therapy after a drug holiday?

2 Answers available

How do you counsel male-to-female transgender patients on the VTE risk of hormonal therapy?

1 Answer available

In a patient with inflammatory orbital disease without a discrete mass to biopsy and recent bisphosphonate use, how much additional workup would you do if basic labs, urine studies, ANCA serologies, thyroid studies, chest imaging (to r/out sarcoid) are normal, before concluding that the process is likely secondary to bisphosphonate use?

Without a discrete mass to biopsy, is there any utility of any blind biopsies to rule out IgG4 related disease, infectious or neoplastic process?

1 Answer available

When do you include the neck in the RT field for resected thyroid cancer?

1 Answer available

Would you consider use of an oral bisphosphonate (such as alendronate liquid) in a patient with eosinophilic esophagitis?

1 Answer available

How would you approach osteoporosis management in a patient who fractures while on denosumab therapy?

Would you consider keeping the patient on denosumab or would switch to an anabolic agent?

1 Answer available

How do you manage anaplastic thyroid cancer that is progressing through radiation therapy?

2 Answers available

How do you approach prophylaxis against glucocorticoid-induced osteoporosis in patients with end-stage renal disease on dialysis?

1 Answer available

Do you avoid teriparatide in previously irradiated breast cancer patients with osteoporosis given the black box warning for potential risk of osteosarcoma?

1 Answer available

How do you diagnose and treat patients who develop uveitis while on bisphosphonate therapy for osteoporosis?

Are there specific features that suggest drug-induced uveitis versus de novo uveitis?

1 Answer available

Do you routinely offer a bisphosphonate or denosumab to multiple myeloma patients without skeletal lesions?

Recommendations in guidelines are discordant (ASCO vs NCCN vs UptoDate).

2 Answers available

Is there a role for starting an anabolic agent in a patient that developed an atypical femoral fracture while on denosumab sooner than 6 months after the last denosumab dose?

Is there a role for earlier use of anabolic agents to promote bone healing in patients that develop AFFs?

2 Answers available

How do you transition to an anabolic agent in a patient who develops an atypical fracture while on denosumab?

1 Answer available

Do you approach therapy differently for patients with a diagnosis of osteoporosis based on a fragility fracture rather than based on bone mineral density on DXA (assuming no secondary causes of osteoporosis)?

1 Answer available

How do you approach therapy for severe osteoporosis after an initial 12 months of romosozumab?

1 Answer available

How do you approach peri-operative management of anti-resorptive therapies such as denosumab in patients undergoing joint replacement?

Does denosumab effect knee replacement or hip replacement? Should replacement occur right before or after injection?

1 Answer available

What agent would you choose for a patient who needs osteoporosis therapy after a bisphosphonate holiday?

2 Answers available

For patients on a bone-modifying agent for osteoporosis/severe osteopenia in the context of adjuvant AI therapy, how do you manage the bone-modifying agent once their AI course is complete?

1 Answer available

How would you approach patient with metastatic anaplastic thyroid cancer with NGS revealing only ARID1A mutation?

1 Answer available

For patients with cancer receiving a bone-modifying agent (bisphosphonate or denosumab) who suffer a fracture requiring stabilization or reconstruction, how do you manage the bone-modifying agent peri-operatively?

Is there concern for impaired healing? Do you pause therapy and for how long?

1 Answer available

Are stress-dose steroids indicated in patients with adrenal insufficiency receiving radiation therapy?

1 Answer available

How do you manage post-menopausal osteoporosis in a patient with stable bone density and no fractures after three years of holiday after giving zoledronic acid?

1 Answer available

How do you manage osteopenia, osteoporosis and calcium / Vit D supplementation in a patient with calcinosis?

1 Answer available

Is romosozumab an option in a patient who has completed 2 years of teriparatide therapy and has a fracture while on denosumab?

1 Answer available

When treating patients with low bone mineral density, when/how do you monitor bone turnover markers (NTX, CTX, etc)?

1 Answer available

Would you consider an osteoporosis medication in a pre-menopausal/young patient with a low Z score and an ongoing risk factor for secondary osteoporosis such as chronic antiepileptic treatment?

1 Answer available

In which osteoporosis patients would you consider starting with anabolic therapy over antiresorptive therapy?

1 Answer available

Do you regularly do bone density testing to screen for osteoporosis in men with rheumatoid arthritis without any other risk factors?

2 Answers available

Following oral cavity radiotherapy, how do you advise patients on ongoing bisphosphonate therapy and the risk for osteonecrosis?

Do you encourage patients to take a break from/stop taking Fosamax or similar medications for their osteopenia or osteoporosis in order to prevent dev...

1 Answer available

Is there any role for bisphosphonate or alternative bone-modifying agents use in SMM in the absence of other indications for its use?

1 Answer available

Do you consent patients for diabetes insipidus following SRS or fractionated radiation for pituitary tumors?

My understanding is that this risk is exceedingly rare even with treatment in and around the stalk and hypothalamus.

2 Answers available

Would you re-introduce bisphosphonate or denosumab in a bone-only metastatic ER+ breast cancer patient with history of osteonecrosis of the jaw?

2 Answers available

Do you give bisphosphonates after completing adjuvant anti-HER2 therapy and chemotherapy for HER2+ breast cancer to reduce the risk of recurrence?

2 Answers available

When is the best time to start denosumab in men with metastatic prostate cancer?

Should it be started at the initial diagnosis of bone mets?

2 Answers available

Is there a degree of osteoporosis (based on T-score) that would prohibit you from the utilization of an AI in a strong HR+ early stage breast cancer?

What factors if any would influence your decision and what would your approach be?

2 Answers available

Do you routinely use imaging (US, whole body iodine scans etc.) to follow papillary or follicular thyroid cancer after thyroidectomy and RAI therapy?

Is there any evidence that this improves outcomes over a more simple and cost effective follow up of careful physical examination and checking a perio...

1 Answer available

Is it safe to use radioactive iodine therapy for patients with differentiated thyroid cancer and brain metastases?

Does it matter whether the intracranial lesions have been treated with whole brain or SRS/SRT?

3 Answers available

What is your approach to the use of denosumab in patients with metastatic breast cancer with bony involvement?

Do you extrapolate the results of OPTIMIZE-2 and CALGB 70604 showing that an every 12 week dosing of zolendronic acid is noninferior to ever...

1 Answer available

How common is hypothyroidism in postradiation head and neck cancer patients?

Do you treat patients who are clinically hypothyroid but biochemically euthyroid?

3 Answers available

How would you follow patients with differentiated thyroid cancer that no longer picks up iodine after thyroidectomy and RAI, and have thyroglobulin antibodies?

If a patient had a recurrence that was pathologically proven despite negative idodine scans, what imaging scans would you follow up with for surveilla...

1 Answer available

What role does external beam radiotherapy play in the treatment of well differentiated papillary thyroid cancer when a total thyroidectomy and lymph node dissection cannot be performed?

In the case of a partial resection with focal perineural invasion, but no lymphadenectomy due to severe fibrosis from prior radio-ablation for hyperth...

1 Answer available

Based on the recent disease-free survival results from ABCSG-18 presented at San Antonio, do you favor the use of Denosumab in the adjuvant setting?

1 Answer available

Should bone-directed agents, such as denosumab or zoledronic acid, be given when patients are being treated with radium-223?

1 Answer available

Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-04-10

Randomized controlled trial of early zoledronic acid in men with castration-sensitive prostate cancer and bone metastases: results of CALGB 90202 (alliance).

Lancet, 2016 Mar 19

Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial.

Eur. Urol.,

Combining enzalutamide with abiraterone, prednisone, and androgen deprivation therapy in the STAMPEDE trial.

Cancer, 2001-12-01

Hypothyroidism: a frequent event after radiotherapy and after radiotherapy with chemotherapy for patients with head and neck carcinoma.

Neuro-oncology, 2011 Jun 10

Hypofractionated stereotactic radiotherapy with CyberKnife for nonfunctioning pituitary adenoma: high local control with low toxicity.

The Journal of clinical endocrinology and metabolism, 2001-12

Inflammatory cardiovascular risk markers in women with hypopituitarism.

J. Clin. Endocrinol. Metab.,

Body composition in adult growth hormone-deficient men, assessed by anthropometry and bioimpedance analysis.

J. Clin. Endocrinol. Metab.,

Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism.

Lancet,

Premature mortality due to cardiovascular disease in hypopituitarism.

Metab. Clin. Exp.,

Serum lipid levels in growth hormone-deficient men.

J. Neurosurg., 2018 Nov 09

Hypopituitarism after Gamma Knife radiosurgery for pituitary adenomas: a multicenter, international study

Clin Endocrinol (Oxf), 2009 Jul 24

Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK).

Nat Clin Pract Endocrinol Metab,

Radiation-induced hypopituitarism after cancer therapy: who, how and when to test.

Neurosurgery, 2008-01

Predictors and incidence of central diabetes insipidus after endoscopic pituitary surgery.

Clinical neurology and neurosurgery, 2013-02

Diabetes insipidus following resection of pituitary tumors.

Ann. Endocrinol. (Paris),

Pituitary deficiency after brain radiation therapy.

Ann. Endocrinol. (Paris), 2013 Nov 25

Diabetes insipidus.

JAMA oncology, 2018-02-01

Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.

Lancet,

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-07-20

Osteonecrosis of the jaw and oral health-related quality of life after adjuvant zoledronic acid: an adjuvant zoledronic acid to reduce recurrence trial subprotocol (BIG01/04).

Curr Treat Options Oncol, 2019 Mar 14

Role of Bisphosphonates in Breast Cancer Therapy.

Leuk. Lymphoma, 2011 Feb 08

Pamidronate versus observation in asymptomatic myeloma: final results with long-term follow-up of a randomized study.

Cancer,

A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma.

Arthritis Rheumatol, 2017 Aug

2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis.

Current opinion in rheumatology, 2015-05

Current approaches to osteoporosis treatment.

Am J Med, 2012 Nov 20

Bisphosphonate therapy for osteoporosis: benefits, risks, and drug holiday.

Arthritis Care Res (Hoboken), 2017 Aug

2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis.

JAMA, 2006-12-27

Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial.

Annals of surgery, 2014-01

A prospective, randomized, noninferiority trial of steroid dosing after major colorectal surgery.

Perioper Med (Lond), 2018 Jun 08

Perioperative corticosteroid administration: a systematic review and descriptive analysis.

BMJ, 2008 May 20

Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis.

Circulation,

Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study.

Cancer discovery, 2015-07

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.

J Immunother Cancer,

alterations function as a biomarker for longer progression-free survival after anti-PD-1/PD-L1 immunotherapy.

J Clin Oncol, 2019 Sep 18

Management of Osteoporosis in Survivors of Adult Cancers With Nonmetastatic Disease: ASCO Clinical Practice Guideline.

Blood, 2013-10-24

The impact of response on bone-directed therapy in patients with multiple myeloma.

The Lancet. Oncology, 2011-08

Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial.

The Lancet. Oncology, 2018-03

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study.

Lancet (London, England), 2015-09-19

Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial.

Int J Part Ther, 2021 Summer

Initial Experience with Proton Beam Therapy for Differentiated Thyroid Cancer.

N Engl J Med,

Bisphosphonate use and atypical fractures of the femoral shaft.

J Clin Oncol, 2022 Jan 18

Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update.

The Journal of clinical endocrinology and metabolism, 2022 Jun 16

Critical Illness-induced Corticosteroid Insufficiency: What It Is Not and What It Could Be.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-12-10

Cost-Effectiveness Analysis of Monthly Zoledronic Acid, Zoledronic Acid Every 3 Months, and Monthly Denosumab in Women With Breast Cancer and Skeletal Metastases: CALGB 70604 (Alliance).

Semin Dial, 2010 May 10

Why dialysis patients need combination therapy with both cholecalciferol and a calcitriol analogs.

The Journal of clinical endocrinology and metabolism, 2016-05

The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline.

Clinical journal of the American Society of Nephrology : CJASN, 2019-05-07

Rate of Correction of Hypernatremia and Health Outcomes in Critically Ill Patients.

Curr Opin Cell Biol, 1995 Aug

Cell volume regulated transporters of compatible osmolytes.

The lancet. Diabetes & endocrinology, 2017-07

10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension.

Post reproductive health, 2022 Dec 27

Hormone replacement therapy in women with history of thrombosis or a thrombophilia.

Cancer Chemother Pharmacol, 2021 Mar 31

Switching from zoledronic acid to denosumab increases the risk for developing medication-related osteonecrosis of the jaw in patients with bone metastases.

J Bone Miner Metab, 2020 Jul 12

Zoledronic acid sequential therapy could avoid disadvantages due to the discontinuation of less than 3-year denosumab treatment.

Endocrine reviews, 2019-02-01

Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update.

Eur J Endocrinol, 2022 Apr 21

Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement.

Pediatr Hematol Oncol, 2023 Mar 20

Growth hormone after CNS tumor diagnosis: the fundamentals, fears, facts, and future directions.

JAMA, 2021 Apr 13

Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial.

Diabetes therapy : research, treatment and education of diabetes and related disorders, 2017 May 08

A Practical Review of C-Peptide Testing in Diabetes.

Journal of the American Heart Association, 2015 Jun 26

Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Mayo Clinic proceedings, 2023 Jun 29

Progression to Insulin Therapy in Patients With Type 2 Diabetes According to Cardiorespiratory Fitness, Body Mass Index, and Statin Therapy.

The Journal of clinical endocrinology and metabolism, 2011 Dec 28

Update in lipid alterations in subclinical hypothyroidism.

The New England journal of medicine, 2022 Apr 21

Calorie Restriction with or without Time-Restricted Eating in Weight Loss.

The lancet. Diabetes & endocrinology, 2019 Aug 22

Combination denosumab and high dose teriparatide for postmenopausal osteoporosis (DATA-HD): a randomised, controlled phase 4 trial.

The New England journal of medicine, 2019 Mar 23

Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.

BMC medicine, 2019-07-10

The TABLET trial: limitations and implications.

JAMA, 2017 Dec 12

Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer: A Randomized Clinical Trial.

The lancet. Diabetes & endocrinology, 2022 Mar 14

Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

The New England journal of medicine, 2020 Sep 24

Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.

The Journal of clinical endocrinology and metabolism, 2010 Jan 15

Fertility in women with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

The New England journal of medicine, 2023 Jun 16

Cardiovascular Safety of Testosterone-Replacement Therapy.

BMC endocrine disorders, 2024 Nov 18

Risk of Hepatocellular Carcinoma with Glucagon-like Peptide-1 receptor agonist treatment in patients: a systematic review and meta-analysis.

International urology and nephrology, 2024 Nov 04

Effect of GLP-1 receptor agonists on prostate cancer risk reduction: a systematic review and meta-analysis.

Cancers, 2024 Sep 22

Risk of Esophageal and Gastric Cancer in Patients with Type 2 Diabetes Receiving Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs): A National Analysis.

Clinics (Sao Paulo, Brazil), 2018 Dec 10

Autophagy and intermittent fasting: the connection for cancer therapy?

Metabolites, 2020 Jul 11

The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH.

Protein & cell, 2014 Jul 12

Regulation of the pentose phosphate pathway in cancer.

Trends in biochemical sciences, 2016 Jan 05

The Warburg Effect: How Does it Benefit Cancer Cells?

The Journal of clinical endocrinology and metabolism, 2005-04

Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine.

European journal of cancer (Oxford, England : 1990), 2012-07

Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status.

The New England journal of medicine, 2018 Oct 01

Fracture Prevention with Zoledronate in Older Women with Osteopenia.

The New England journal of medicine, 2015 Sep 17

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.

The New England journal of medicine, 2020 Sep 24

Dapagliflozin in Patients with Chronic Kidney Disease.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018-05

Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT.

The American journal of medicine, 2016-05

Diagnosing and Treating the Syndrome of Inappropriate Antidiuretic Hormone Secretion.

Clinical journal of the American Society of Nephrology : CJASN, 2018-07-06

Risk Factors and Outcomes of Rapid Correction of Severe Hyponatremia.

Journal of critical care, 2023 May 13

Effects of correction rate for severe hyponatremia in the intensive care unit on patient outcomes.

The Journal of urology, 1992-06

Functional obstructive uropathy: a significant factor in the hyponatremia of psychogenic polydipsia?

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2019-02

THE EVALUATION OF INCIDENTALLY DISCOVERED ADRENAL MASSES.

European journal of endocrinology, 2023 Jul 20

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.

JBMR plus, 2021 Aug 30

New Insights Into Osteoclast Biology.

World journal of surgery, 2004 Apr 19

Recovery of bone mineral density in 126 patients after surgery for primary hyperparathyroidism.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-05-10

Twelve-Month Estrogen Levels in Premenopausal Women With Hormone Receptor-Positive Breast Cancer Receiving Adjuvant Triptorelin Plus Exemestane or Tamoxifen in the Suppression of Ovarian Function Trial (SOFT): The SOFT-EST Substudy.

The New England journal of medicine, 2018-07-12

Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-05-10

Incomplete Estrogen Suppression With Gonadotropin-Releasing Hormone Agonists May Reduce Clinical Efficacy in Premenopausal Women With Early Breast Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-04-10

Ovarian Suppression in Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.

Clinical breast cancer, 2023 Mar 28

Ovarian Function Suppression in Premenopausal Women With Concurrent Endocrine Therapy Use.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010 Jun 14

Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial.

The New England journal of medicine, 2023 Aug 25

Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.

Kidney international, 2022 Nov

Executive summary of the KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease: an update based on rapidly emerging new evidence.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023 Jan 18

The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease.

Cardiovascular diabetology, 2024 Feb 08

Cardiorenal effectiveness of empagliflozin vs. glucagon-like peptide-1 receptor agonists: final-year results from the EMPRISE study.

The New England journal of medicine, 2024 May 24

Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes.

Diabetes care, 2011-09

Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial.

Nutrients, 2023 Aug 18

Effects of Oral Alpha-Lipoic Acid Treatment on Diabetic Polyneuropathy: A Meta-Analysis and Systematic Review.

Endocrine reviews, 2019 Feb 01

Emerging Biomarkers, Tools, and Treatments for Diabetic Polyneuropathy.

The lancet. Diabetes & endocrinology, 2021 Oct 20

Consensus on diagnosis and management of Cushing's disease: a guideline update.

Blood advances, 2017 Dec 21

Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study.

Arteriosclerosis, thrombosis, and vascular biology, 2019-07

Cardiovascular Outcomes of Romosozumab and Protective Role of Alendronate.

The New England journal of medicine, 1980-04-17

Combination of potassium iodide and propranolol in preparation of patients with Graves' disease for thyroid surgery.

International journal of endocrinology, 2015 Oct 20

Lithium Carbonate in the Treatment of Graves' Disease with ATD-Induced Hepatic Injury or Leukopenia.

Clinical journal of the American Society of Nephrology : CJASN, 2017-08-07

Low Bone Density and Bisphosphonate Use and the Risk of Kidney Stones.

Endocrine, 2019 Nov 21

Primary hepatocellular adenoma due to biallelic HNF1A mutations and its co-occurrence with MODY 3: case-report and review of the literature.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013-04

Hypertonic saline and desmopressin: a simple strategy for safe correction of severe hyponatremia.

Calcified tissue international, 2022 Oct 26

One-Year Romosozumab Treatment Followed by One-Year Denosumab Treatment for Osteoporosis in Patients on Hemodialysis: An Observational Study.

Thyroid : official journal of the American Thyroid Association, 2018 Apr 05

An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.

Nature reviews. Endocrinology, 2022 Jan 18

Primary hypothyroidism and quality of life.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2020 Sep

Adrenal Vein Sampling Without Discontinuation of Mineralocorticoid Receptor Antagonist Therapy.

European journal of endocrinology, 2022 Nov 22

Cardiovascular outcomes and all-cause mortality in primary aldosteronism after adrenalectomy or mineralocorticoid receptor antagonist treatment: a meta-analysis.

Journal of cardiovascular development and disease, 2022 Sep 08

Stroke Risks in Primary Aldosteronism with Different Treatments: A Systematic Review and Meta-Analysis.

International journal of radiation oncology, biology, physics, 2024 Oct 23

Hormone Replacement Therapy in Patients with Gynecologic Cancer and Radiation-Induced Premature Ovarian Insufficiency.

Curr Rheumatol Rep, 2020 Aug 26

Lipid-lowering Therapies in Myositis.

JMIR diabetes, 2023 Sep 11

Impact of a Combined Continuous Glucose Monitoring-Digital Health Solution on Glucose Metrics and Self-Management Behavior for Adults With Type 2 Diabetes: Real-World, Observational Study.

JAMA network open, 2024 Mar 04

MACE and Hyperthyroidism Treated With Medication, Radioactive Iodine, or Thyroidectomy.

The lancet. Diabetes & endocrinology, 2019 Feb 28

Primary therapy of Graves' disease and cardiovascular morbidity and mortality: a linked-record cohort study.

BJS open, 2022 Jul 07

Attaining biochemical euthyroidism early after total thyroidectomy in Graves' disease may lower long-term morbidity risk.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2018-10-05

CALCIUM CREATININE CLEARANCE RATIO IS NOT HELPFUL IN DIFFERENTIATING PRIMARY HYPERPARATHYROIDISM FROM FAMILIAL HERPERCALCEMIC HYPOCALCIURIA: A STUDY OF 1000 PATIENTS.

Pituitary, 2022 May 26

The NETting of pituitary adenoma: a gland illusion.

Clinical endocrinology, 2018-01

Diagnostic performance of unenhanced computed tomography and 18 F-fluorodeoxyglucose positron emission tomography in indeterminate adrenal tumours.

Annals of oncology : official journal of the European Society for Medical Oncology, 2022 Mar 14

Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study.

N Engl J Med, 2023 Mar 02

Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence.

The New England journal of medicine, 2024 Apr 06

Empagliflozin after Acute Myocardial Infarction.

Joint bone spine, 2021 May 19

Effects of prior osteoporosis treatment on 12-month treatment response of romosozumab in patients with postmenopausal osteoporosis.

Genes, 2022 Oct 17

Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management.

JAMA, 2007-01-24

Risk of subsequent fracture after low-trauma fracture in men and women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017-07

Osteoporosis in Crisis: It's Time to Focus on Fracture.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019 Dec 01

Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition.

JAMA network open, 2022 Oct 03

Association of Multimorbidity and Excess Mortality After Fractures Among Danish Adults.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022 Oct 17

The Economic Burden of Severe Osteoporotic Fractures in the French Healthcare Database: The FRACTOS Study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020 Mar 16

Fracture risk following high-trauma versus low-trauma fracture: a registry-based cohort study.

The New England journal of medicine, 2016 Sep 15

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.

The American journal of cardiology, 2004-02-01

Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study).

Nature medicine, 2024 Feb 19

A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.

Journal of clinical lipidology, 2024 Mar 29

A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice.

BMJ (Clinical research ed.), 2007 Feb 19

Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials.

European journal of endocrinology, 2003 Dec

Resumption of methimazole after 131I therapy of hyperthyroid diseases: effect on thyroid function and volume evaluated by a randomized clinical trial.

Current osteoporosis reports, 2021 Feb 01

Approaches to Fracture Risk Assessment and Prevention.

The Journal of clinical endocrinology and metabolism, 1974 Nov

Serum thyroid hormone and thyrotropin concentrations during thyroxine and triiodothyronine therapy.

Diabetes Care, 2024 Jan 1

15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes-2024.

The New England journal of medicine, 2013 Sep 12

Gonadal steroids and body composition, strength, and sexual function in men.

Journal of thrombosis and haemostasis : JTH, 2019 Sep 13

Transgender patients and the role of the coagulation clinician.

The Journal of clinical endocrinology and metabolism, 2024 Jan 18

Approach to the Patient: Hormonal Therapy in Transgender Adults With Complex Medical Histories.

Diabetes care, 1999-08

Glucose intolerance and 23-year risk of coronary heart disease and total mortality: the Honolulu Heart Program.

Diabetes research and clinical practice, 1994 Jan

Insulin autoimmune syndrome (Hirata disease): clinical features and epidemiology in Japan.

Clinical endocrinology, 2020 Feb 26

Management of Insulin Autoimmune Hypoglycaemia: Single-centre experience from Western India with systematic review of world literature.

Journal of the Endocrine Society, 2022 Dec 02

Perioperative Evaluation and Management of Patients on Glucocorticoids.

Diagnostics (Basel, Switzerland), 2021 Apr 20

Glucocorticoid Withdrawal-An Overview on When and How to Diagnose Adrenal Insufficiency in Clinical Practice.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2024 Mar 28

Proton Pump Inhibitors Do Not Affect the Bioavailability of a Novel Liquid Formulation of Levothyroxine.

Journal of general internal medicine, 2021 Jan 19

Concomitant Use of Levothyroxine and Proton Pump Inhibitors in Patients with Primary Hypothyroidism: a Systematic Review.

Frontiers in pharmacology, 2023 Mar 16

Glucagon-like peptide-1 receptor agonists as add-on therapy to insulin for type 1 diabetes mellitus.

Nutrition & diabetes, 2019 Nov 04

Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors.

Diabetes, obesity & metabolism, 2019 Aug 19

Double diabetes: A distinct high-risk group?

BMC endocrine disorders, 2021 Sep 16

The association between overweight/obesity and double diabetes in adults with type 1 diabetes; a cross-sectional study.

Frontiers in endocrinology, 2022 Aug 18

Cortisol values during the standard-dose cosyntropin stimulation test: Personal experience with Elecsys cortisol II assay.

The Journal of clinical endocrinology and metabolism, 2023 Sep 18

Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.

European journal of endocrinology, 2018 Apr 27

Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.

BMJ open, 2024 Apr 24

Use of GLP1 receptor agonists in early pregnancy and reproductive safety: a multicentre, observational, prospective cohort study based on the databases of six Teratology Information Services.

The New England journal of medicine, 2023 Oct 18

Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes.

N Engl J Med,

Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis.

Autoimmunity reviews, 2023 Dec 20

Implementation of regulatory guidance for JAK inhibitors use in patients with immune-mediated inflammatory diseases: An international appropriateness study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020 Apr 24

Radioiodine Ablation of Remaining Thyroid Lobe in Patients with Differentiated Thyroid Cancer Treated by Lobectomy: A Systematic Review and Metaanalysis.

Stroke, 2007-12

Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.

The New England journal of medicine, 2006 Aug 10

High-dose atorvastatin after stroke or transient ischemic attack.

European heart journal, 2020 Jan 01

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.

Journal of the American Heart Association, 2023 Sep 08

Statin Treatment in Patients With Stroke With Low-Density Lipoprotein Cholesterol Levels Below 70 mg/dL.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023 Jul 01

Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging.

Diabetes care, 2021 May 05

High Burden of Subclinical and Cardiovascular Disease Risk in Adults With Metabolically Healthy Obesity: The Atherosclerosis Risk in Communities (ARIC) Study.

Hospital & community psychiatry, 1983 Dec

The dexamethasone suppression test: promises and problems of diagnostic laboratory tests in psychiatry.

Clinical endocrinology, 1978 Nov

Endocrine effects of spironolactone in man.

The Journal of steroid biochemistry and molecular biology, 2013 Mar 06

Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer.

The Journal of clinical endocrinology and metabolism, 2007-05

The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.

The Journal of clinical endocrinology and metabolism, 1975 Oct