Infectious Disease

Questions discussed in this category

What is the interpretation of two IGRAs with negative mitogen wells, in the absence of immunosuppression?

A patient on meloxicam for LBP developed high, persistent fevers and no other symptoms. An IGRA, among many tests, was sent. The IGRA’s mitogen ...

2 Answers available

How do you factor cerebrospinal fluid (CSF) antibody results when deciding on the diagnosis and treatment of racemose neurocysticercosis, given the uncertainties associated with CSF antibody testing?

1 Answer available

What is your approach when cryptococcus serum or CSF antigen titers do not change despite treatment in HIV-positive patients with cryptococcal meningitis or invasive disease, but there is clinical improvement and cultures remain negative?

1 Answer available

How would you manage a patient with Crohn's disease on a biologic and presents with non-bloody diarrhea, normal-appearing mucosa on sigmoidoscopy but severe colitis on biopsy with a positive CMV stain?

Would you send a CMV DNA PCR in blood, and if you elect to treat with anti-CMV medication, how long would you treat and what parameters would you use,...

1 Answer available

What oral treatment options would you offer a patient with severe onychomycosis who is also on methotrexate for another condition?

2 Answers available

What specific criteria or patient conditions would make you hesitant to use fluoroquinolones early in the treatment course for managing MSSA joint infections with oral antibiotics?

For example, baseline QT prolongation, elderly age group, or underlying heart disease?

3 Answers available

How would you manage a patient with progressive/refractory molluscum contagiosum who is well controlled on methotrexate for seropositive rheumatoid arthritis?

Are you aware of any data regarding relative risk of molluscum contagiosum infection in reference to DMARDs/biologics?

1 Answer available

What are the current treatment options for progressive multifocal leukoencephalopathy in patients without HIV/AIDS?

Are there any clinical trials underway to study additional therapies?

1 Answer available

What duration of antibiotics do you use in patients with Actinomyces osteomyelitis, i.e., do you stop after 6 weeks or do you give a longer oral antibiotic course?

1 Answer available

How do you decide between ceftolozane/tazobactam and ceftazidime/avibactam for empiric treatment of an infection due to difficult-to-treat Pseudomonas aeruginosa while awaiting additional susceptibilities?

2 Answers available

Which biomarkers or diagnostic tools do you prioritize to support the decision to start antifungal treatment in septic patients with no clear source of infection but at high risk for fungal infections?

2 Answers available

Do you favor timely bronchoscopy for diagnostics over close surveillance in mildly symptomatic patients with CT findings suspicious for NTM infection who are not able to expectorate?

4 Answers available

Do add a macrolide for immunomodulatory effect in patients with macrolide-resistant M. abscessus?

2 Answers available

Do you use steroids in the management of PJP pneumonia with severe hypoxia in HIV negative patients?

Data on the role of steroids in HIV negative patients with PJP has been conflicting.

2 Answers available

Do you use standard dose or "meningitis dosing" of antibiotics when treating epidural abscesses, in the absence of CNS symptoms?

5 Answers available

What is your preferred first-line treatment for chronic fatigue in patients with long COVID-19?

7 Answers available

Do you add adjunctive gentamicin and/or rifampin for treatment of prosthetic valve Staphylococcus aureus endocarditis?

3 Answers available

How do you approach management for patient's with HIV on ART with persistent low level viremia but no new resistance mutations identified?

1 Answer available

What is your approach to a positive PPD or IGRA in a patient with well-controlled HIV without significant TB risk factors?

3 Answers available

Do you routinely treat patients with neurosyphilis with IM penicillin for 1-3 weeks after completing a full treatment course of IV penicillin?

https://www.cdc.gov/std/treatment-guidelines/neurosyphilis.htm

1 Answer available

Would you use the pneumococcal conjugate-21 vaccine (Capvaxive) instead of the conjugate-20 (Prevnar-20) for routine vaccinations in immunosuppressed patients?

2 Answers available

Do you routinely consider FDG PET/CT imaging for workup of fever of unknown origin?

1 Answer available

What are your top takeaways from ID Week 2024?

1 Answer available

Do you consider the use of tocilizumab in patients with COVID pneumonia who have had an improvement in supplemental O2 requirements but have significantly elevated inflammatory markers after day two of remdesivir and dexamethasone?

1 Answer available

What is the utility of granulocyte infusions in patients with neutropenia and severe infection?

1 Answer available

Do you avoid performing urine microscopy in patients with AKI who have COVID-19 given concern for potential aerosolization?

2 Answers available

Are there clinical scenarios in which you would start empiric treatment for pulmonary TB without microbiologic confirmation?

2 Answers available

Are there instances when you use letermovir without the addition of acyclovir when managing a kidney transplant recipient for CMV prophylaxis?

2 Answers available

How would you manage persistent Norovirus diarrheal infections in a kidney transplant patient that are not responding to a decrease in the patient’s maintenance immunosuppressive regimen?

1 Answer available

When would you initiate exchange transfusion in babesiosis and significant hemolysis?

Is parasitemia >10% and severe hemolysis with Hb less than 7 enough to initiate this?

1 Answer available

Do you take into consideration a patient's serum albumin level in your decision to use ertapenem?

2 Answers available

Do you routinely recommend a lumbar puncture for patients with suspected ocular or otic syphilis in the absence of additional CNS symptoms?

3 Answers available

Do you routinely treat chronic sacral osteomyelitis when there is no plan for debridement or flap?

2 Answers available

What is your approach to recurrent asymptomatic bacteriuria in pregnancy for patients without personal history of recurrent UTIs or pyelonephritis?

Assuming patient already received an initial course of antibiotic treatment in response to a positive urine culture during routine screening early in ...

2 Answers available

How do you decide on the timing and number of blood cultures for suspected endocarditis given the differences in recommendations between the ESC guidelines and the Duke Criteria?

The ESC guidelines recommend obtaining at least three sets of blood cultures at 30-minute intervals before starting antibiotic therapy, each with 10 m...

3 Answers available

Do you add gentamicin when treating prosthetic valve endocarditis secondary to viridans group Streptococcus with a penicillin-intermediate isolate (MIC >0.125 - <0.5)?

2 Answers available

Would you treat a sputum culture positive for Aspergillus niger despite an atypical CT chest and a negative serum galactomannan in an immunosuppressed patient who is too high risk for bronchoscopy?

0 Answers available

How often do you see bony erosions in patients with Lyme arthritis?

1 Answer available

What is your approach to deciding when to stop therapy for cutaneous Mycobacterium chelonae infections?

1 Answer available

How do you integrate next-generation sequencing with traditional culture methods to improve the identification of fungal pathogens, especially in cases where routine cultures are negative when evaluating suspected prosthetic joint infections?

1 Answer available

How do you approach a patient on anti-TNF with positive Quantiferon (previously negative) with negative chest x-ray and no symptoms?

7 Answers available

What infections should we rule out in patients who develop diarrhea on immunotherapy?

Chemotherapy is associated with acquiring C diff colitis. Does immunotherapy share that same risk and necessitate ruling out infection prior to anti-d...

1 Answer available

Do you routinely perform echocardiography in patients with Staphylococcus aureus bacteremia deemed low risk for metastatic infection, or do you selectively omit it based on specific clinical criteria?

Hendriks, et al., PMID 38576380

2 Answers available

Under what circumstances do you consider valacyclovir for the management of VZV disease of the CNS?

2 Answers available

When treating pancreatic body/tail lesions that result in significant dose spread to the spleen, what is your threshold to offer pneumococcal, hemophilus influenza, and meningococcal vaccines?

2 Answers available

Are there any concerns with live vaccine innoculation and patients who are on denosumab?

1 Answer available

Is there a role for suppressive antibiotic therapy when it comes to chronic femoral/tibial osteomyelitis?

1 Answer available

In patients with possible Bartonella henselae infection and elevated IgG titer, what is the best way to confirm the diagnosis: tissue biopsy with Warthin-Starry staining, tissue sent for Bartonella henselae PCR, or tissue sent for culture?

1 Answer available

How would you approach treatment of latent TB for patients who cannot tolerate rifamycins or isoniazid due to allergy, intolerance, or drug-drug interactions?

2 Answers available

What agent and for how long would you treat a patient with asymptomatic azole-resistant C auris candiduria who is planning to undergo a urological procedure?

3 Answers available

Do you routinely recommend IV systemic antibiotic therapy in additional to intravitreal antibiotic therapy for exogenous bacterial endophthalmitis?

1 Answer available

Do you preferentially avoid use of piperacillin-tazobactam for empiric anti-pseudomonal coverage in hospitalized patients due to risk of nephrotoxicity?

ACORN Randomized Clinical Trial

1 Answer available

What steps do you recommend to ensure continued viral suppression and prevent drug resistance in an HIV patient on injectable cabotegravir and rilpivirine who misses their scheduled injection appointment by two weeks?

1 Answer available

How would you manage a patient with well controlled HIV on Biktarvy, who is interested in switching to injectable HAART but also has a history of a prior Hepatitis B Infection?

2 Answers available

Do you routinely check cefepime levels in patient's with suspected cefepime-induced neurotoxicity?

1 Answer available

How would you approach treatment duration for patients with persistent candida species fungemia with a history of a prosthetic heart valve but negative TEE/CT PET and no other identifiable source of infection?

2 Answers available

Do you recommend starting anti-fungal prophylaxis for patients on systemic antibiotics who have a peritoneal dialysis catheter that is only currently being accessed for once weekly flushes?

1 Answer available

What is your preferred oral regime with duration for treatment of onychomycosis?

How frequently can you repeat the oral course?

4 Answers available

Would you transition from IV to oral antibiotics in a solid organ transplant recipient with uncomplicated gram-negative bacteremia?

Nussbaum et al., PMID 38195100

1 Answer available

Do you treat prosthetic joint infections after a two-stage revision arthroplasty with oral antibiotics for the full duration of therapy, assuming a susceptible oral option is available?

1 Answer available

What is your approach to management of CIED in a patient with community-acquired Staph aureus bacteremia who clears blood cultures quickly with negative follow up blood cultures within 72 hours of antimicrobial therapy and negative TEE?

Would you still routinely ask for CIED removal, or would you pursue PET/CT for further evaluation and consider keeping CIED if PET/CT negative?

2 Answers available

Is there a role for nitazoxanide for treatment of norovirus gastroenteritis in immunocompromised patients?

1 Answer available

Is there a role for empiric scabies treatment in itchy patients without clear clinical signs of scabies?

Do you empirically treat itchy patients -with a non specific rash- for scabies without obvious clinical findings for scabies?

5 Answers available

Under which circumstances is there a role for reduction in immunosuppression post-SOT in a patient with recurrent CMV viremia and/or disease?

1 Answer available

What is your approach to monitoring of inflammatory markers during treatment of native vertebral osteomyelitis?

3 Answers available

Do you give additional pneumococcal vaccines after a dose of PCV20 in patients with asplenia?

1 Answer available

Is there a role for routine LP in HIV patients with disseminated histoplasmosis even in the absence of CNS signs/symptoms?

Extrapolating from standard practice for management of cryptococcal antigenemia?

1 Answer available

What is your preferred third antimicrobial agent for a patient with treatment-naive pulmonary MAC without cavitary disease and strict contraindications to utilization of rifampin or rifabutin?

3 Answers available

Would you recommend starting a moderate-intensity statin in a patient under the age of 40 years old with HIV and a 10-year ASCVD risk estimate below 5%?

The REPRIEVE trial included participants who were between 40 and 75 years old.

1 Answer available

What is the preferred four-drug regimen for initial treatment of pan-susceptible tuberculous meningitis, given the need to achieve optimal CNS penetration?

1 Answer available

In drawing blood cultures from a central line to evaluate for CLABSI, do you advise drawing separate blood cultures from each port in case of dual or triple lumen line?

If yes, what is the rationale for doing that?

3 Answers available

When would you add a third antibacterial agent in addition to macrolide and ethambutol for treatment of a patient with HIV and disseminated MAC?

1 Answer available

Is there a role for cefpodoxime for treatment of acute cystitis caused by an Enterobacterales isolate with resistance to cefazolin, but susceptibility to ceftriaxone?

Can cefpodoxime susceptibility be reliably extrapolated from ceftriaxone susceptibility?

1 Answer available

In clinical practice, are you using single-dose liposomal amphotericin B for treatment of cryptococcal meningitis for patients living with HIV?

1 Answer available

Do you find HZV titers useful in diagnosing shingles sine herpete?

1 Answer available

Do you use combination antibiotic therapy for treatment of bacterial endocarditis due to gram-negative bacilli?

1 Answer available

How have you adjusted your practice for treatment of syphilis in light of the penicillin G benzathine shortage?

3 Answers available

What is your approach to monitoring blood parasite smears in an immunocompetent patient with babesiosis?

Do you continue smears until documented resolution, or by clinical progress?

1 Answer available

What is your approach to antimicrobial prophylaxis in adult patients undergoing treatment for HLH?

1 Answer available

Do you use combination therapy for persistent MSSA bacteremia?

If yes, which combination(s)?

1 Answer available

Under what circumstances would you recommend the maternal RSV vaccine for a pregnant patient if nirsevimab will also be available for the infant after birth?

1 Answer available

Is there a role for secondary CMV prophylaxis in solid organ transplant patients?

1 Answer available

Under what circumstances would you recommend early fecal microbiota transplantation over antibiotic treatment or bezlotoxumab in a patient with recurrent C. difficile infection?

1 Answer available

Have you used Karius to aid in the diagnosis of a non-resolving pneumonia, with negative bronchoscopy, biopsy, and other infectious work up in an immunocompetent patient?

1 Answer available

Do you routinely ask for removal of a indwelling central line (PICC or tunneled catheter) in a patient with pseudomonal bacteremia from known source with otherwise appropriate clinical improvement on anti-pseudomonal antibiotic therapy?

1 Answer available

How exhaustive (especially considering cost) should an immunological workup be for patients with extensive, recurrent, or deep seated Staph aureus infections without obvious immunocompromise (e.g. cancer, diabetes, steroids) or recurrent breaks in skin integrity?

1 Answer available

Do you transition to oral antibiotics to treat uncomplicated Staphylococcus aureus bacteremia after patients have improved with intravenous antibiotic therapy?

4 Answers available

Have you incorporated the use of linezolid in lieu of vancomycin plus clindamycin for empiric treatment of necrotizing fasciitis?

1 Answer available

Do you recommend lifelong antibiotic prophylaxis, or do you prefer a more selective approach based on risk factors in asplenic patients without a history of severe infections?

2 Answers available

Is there any role for additional antiviral therapy during rebound from COVID-19 infection after a course of Paxlovid?

2 Answers available

Are there clinical circumstances in which there is a role for steroids in treatment of calcified neurocysticercosis associated with perilesional edema and seizures?

1 Answer available

Do you administer prophylactic antibiotics to prevent VAP following intubation in patients with acute brain injury?

Do the findings of the PROPHY-VAP trial influence your approach?

2 Answers available

How long would you treat an upper urinary tract infection in a patient with acute obstructive pyelonephritis due to a kidney stone status-post urinary stenting without yet removal of the stone?

4 Answers available

Do you recommend routine ophthalmologic exam for all patients with hypervirulent Klebsiella pneumoniae bacteremia?

1 Answer available

Do you choose an antibiotic with CSF penetration, such as nafcillin over cefazolin, in the setting of MSSA endocarditis with septic emboli to the brain (assuming no concomitant meningitis or brain abscess)?

3 Answers available

Do you consider use of convalescent plasma early in disease course in COVID-19 induced ARDS in mechanically ventilated patients?

Do the results of the recent study (Misset et al., PMID 37889107) showing reduction in 28-day mortality in patients with high neutralizing antibody ti...

1 Answer available

Is there any utility to trending Histoplasma serology titers to guide duration of therapy or treatment response for pulmonary histoplasmosis with negative urine antigen?

1 Answer available

How do you approach a positive Quantiferon/PPD test result in a patient for whom testing is sent without a clinical indication and who does not have a risk factor for TB exposure nor TB reactivation?

Do you routinely offer latent TB treatment in these cases?

2 Answers available

What is your approach to duration of fidaxomicin in a patient receiving treatment for first C difficile infection while also receiving concurrent antibiotics for an infection?

Do you extend the course of fidaxomicin past initial 10 days to at least 3-7 days after completion of antibiotics?

1 Answer available

How do you approach restarting cDMARDS/bDMARDS in a patient with active RA after incidence of disseminated CNS VZV infection while on tofacitinib?

1 Answer available

For which patients or under which circumstances do you recommend a 9-month over a 6-month course of isoniazid for treatment of LTBI?

1 Answer available

Do you routinely refer all patients with cutaneous leishmaniasis with a species associated with mucocutaneous leishmaniasis to ENT for comprehensive nasal/oropharyngeal evaluation, or do you refer only if mucocutaneous involvement is suspected based on careful clinical assessment and/or bedside exam?

1 Answer available

Do you adhere to the standard 5-day minimum treatment duration for community-acquired pneumonia, or have you used shorter courses for certain low-risk patients?

1 Answer available

Have you used oral vancomycin as prophylaxis for C difficile infection in patients admitted for allogeneic hematopoietic cell transplant?

2 Answers available

What is your approach to treatment of patients with fulminant C difficile infection who required ileostomy creation or colectomy?

Is there a role for oral vancomycin in these patients, or is oral vancomycin redundant if other routes of administration are being used (i.e intracolo...

1 Answer available

What is your approach to antiviral treatment of HSV acute retinal necrosis?

Is there a role for oral antiviral therapy alone (as opposed to induction with IV) and for what duration? And is there a role for ongoing suppressive ...

1 Answer available

Is there a risk of hepatitis C activation with rituximab in a patient who has a history of HCV treated with antivirals and who is in sustained viral response?

1 Answer available

How do you counsel HIV patients with an undetectable viral load on breastfeeding?

2 Answers available

What is your approach to use of D-mannose for prevention of recurrent uncomplicated cystitis?

Especially in light of the results of the randomized clinical trial published on 8/2024 in Jama Internal Medicine by Hayward et al., PMID 38587819.

1 Answer available

Do you periodically check a urine culture for patients without dysuria but who have a history of struvite kidney stones and urinary tract infections with urease producing organisms?

1 Answer available

Do you use oral fosfomycin as a treatment option for uncomplicated cystitis due to ESBL producing E coli?

1 Answer available

For which patients could you consider direct oral amoxicillin challenge as opposed to skin testing for penicillin allergy de-labeling?

1 Answer available

For how long would you treat Klebsiella aerogenes folliculitis of the face manifesting as a cystic lesion?

Would you combine antibiotics with isotretinoin?

2 Answers available

Do you recommend antibiotic prophylaxis for an ESKD patient with a tunneled dialysis catheter who is planned for a dental procedure?

2 Answers available

What is your approach to counseling patients regarding re-initiation of anti-TNF therapy after completion of treatment for non-disseminated pulmonary histoplasmosis?

Would it be safe to resume and if so, when?

2 Answers available

Do you prescribe linezolid to patients who are concomitantly on an SSRI?

7 Answers available

Do you consider late latent syphilis adequately treated if a patient receives a 10-14 day course of IV ceftriaxone for another indication?

Or would you still offer penicillin G benzathine once weekly concurrently?

1 Answer available

Would you give treatment to a male patient with subjective dysuria but no objective pyuria with Ureaplasma urealyticum detected by PCR from urine?

1 Answer available

For how long do you recommend treatment for latent tuberculosis prior to initiation of anti-TNF therapy?

6 Answers available

How long would you treat a patient with recent history of TAVR presenting with E faecalis bacteremia with unclear source with TEE showing thickened valves but no obvious vegetation?

2 Answers available

How long do you treat an isolated bacterial liver abscess which has either undergone percutaneous drainage or for which an indwelling drain is placed?

3 Answers available

How long do you treat uncomplicated gram-negative rod bacteremia in solid organ transplant recipients?

1 Answer available

Is history of GBS a contraindication for all future flu vaccines?

2 Answers available

What is your approach to the use of Paxlovid for patients with risk factors for severe Covid-19 infection but who have received SARS-CoV-2 vaccines in light of the EPIC-SR trial findings?

EPIC-SR Trial

2 Answers available

How do you apply the CDC PrEP guidelines for cisgender women, particularly when faced with underreported risk behaviors or uncertain partner HIV status?

1 Answer available

What is your approach to duration of systemic antibiotics for treatment of isolated bacterial endophthalmitis in the absence of bacteremia or other deep-seated metastatic foci of infection?

1 Answer available

What is your approach to a patient with undetectable MMR titers checked prior to or during immunosuppression and a history of MMR vaccination in childhood?

Is there a role for booster vaccination and if so, how do you approach the timing when a patient is already on a biologic for immunosuppression?

1 Answer available

When do you discontinue contact precautions in patients known to be colonized with ESBL producing Enterobacterales?

2 Answers available

How long do you continue PJP prophylaxis in a patient with GPA who is able to wean steroids and remains only on rituximab for maintenance therapy?

1 Answer available

How do you treat a patient with a gram-negative infection with resistance to imipenem but sensitivity to meropenem and negative for Carbapenem resistant organism by xpert Carba-R-assay?

1 Answer available

Have you incorporated the use of steroids for patients with severe community-acquired pneumonia?

In light of published data from the CAPE COD trial...

1 Answer available

Is there a role for repeat surveillance blood cultures in patients with prosthetic valve endocarditis without associated cardiac abscess after a 6 week course of antibiotic treatment without surgical intervention?

1 Answer available

Is there a role for chronic suppressive oral or inhaled therapy for recurrent Burkholderia cepacia pneumonia causing frequent hospitalizations in a patient with severe bronchiectasis with or without underlying cystic fibrosis?

3 Answers available

How do you approach a patient who has anterior uveitis and is referred for evaluation of ocular TB with a positive Quantiferon gold (as part of their workup) in countries with low TB incidence?

2 Answers available

What is your approach to treatment of macrolide-sensitive localized bone/joint MAC disease?

1 Answer available

Does a low serofast RPR titer (such as 1:1 or 1:2) in the setting of a remote history of appropriately treated latent syphilis in a patient with now uveitis of yet unknown etiology referred from ophthalmology for possible ocular syphilis make a diagnosis of ocular syphilis less likely?

What is your approach to guiding ophthalmologists regarding our clinical suspicion for ocular syphilis and does the quantification of the titer help i...

1 Answer available

In addition to ampicillin, is there any benefit to the addition of either gentamicin or bactrim when treating a patient with listeria meningitis?

2 Answers available

Are contact precautions effective at preventing MRSA transmission in healthcare settings?

2 Answers available

What is your approach to anal pap screening among MSM with HIV, and if routinely recommend, starting at what age (assuming access to HRA)?

1 Answer available

Have you applied the POET trial to clinical practice?

1 Answer available

Does your institution have formal policies or work flows to reduce unnecessary IGRAs ordered for patients on biologics?

1 Answer available

What is current best practice with regards to antibacterial prophylaxis in patients with hematologic malignancy and resolved neutropenic fever (>72 hours)?

1 Answer available

How long do you continue antibiotics after cholecystostomy tube placement for acute cholecystitis?

Since the COVID-19 pandemic, increasingly we see management of acute cholecystitis with cholecystostomy tubes as opposed to surgery, even amongst pati...

1 Answer available

What approaches can we take to initiate therapy and improve survival rates in patients with HLH?

1 Answer available

What isolation policies are Rheumatology offices employing for both staff and patients diagnosed with COVID-19 given the new CDC guidelines?

CDC Healthcare Guidance CDC Isolation and Work Restriction Guidance CDC Immunocompromised Guidance

1 Answer available

What antibiotic, antifungal and antiviral prophylaxis you give post CAR-T therapy, and what is the duration?

1 Answer available

In which patients do you prefer daily standard three-drug therapy for non-cavitary pulmonary MAC as opposed to three times a week dosing?

2 Answers available

Do you repeat a lumbar puncture in a patient living with HIV diagnosed with and treated for neurosyphilis and if so, when?

1 Answer available

What duration of therapy do you use for treatment of Legionella pneumonia in an immunocompetent host without associated empyema or extrapulmonary infection?

2 Answers available

In patients with HTLV-1 associated acute T-cell leukemia, is there any clear benefit of adding antivirals?

If yes, would you go with Zidovudine monotherapy versus combining with interferon-alpha? And what would be the preferred dose and duration?

1 Answer available

Is there a role for beta-lactams as step-down oral therapy for uncomplicated gram-negative bacteremia?

If so, what antibiotic regimens do you use?

6 Answers available

Do you recommend testing for HPV in patients with oral lichen planus?

2 Answers available

Should checking a urinalysis with reflex to culture be part of the standard work up for fever in an ICU patient with a urinary catheter?

2 Answers available

Can non-16/18 HPV types cause ASCUS and squamous cervical metaplasia on biopsy within 3 months of acquisition, or would it take longer?

1 Answer available

What is the preferred treatment regimen for cardiovascular syphilis, specifically syphilitic ostial coronary artery disease?

1 Answer available

How do you approach biologic initiation in patients with inflammatory arthritis and repeatedly indeterminate Quantiferon?

5 Answers available

How do you approach ongoing screening for TB in patients with a history of treated latent TB, but who have ongoing use of DMARDs and/or biologics given Quantiferon testing and PPD can remain positive?

How do you approach ongoing screening for TB in patients with history of treated latent TB, but have ongoing use of DMARDs and/or biologics given quan...

1 Answer available

For patients on PrEP, is there a role for HIV RNA PCR screening in addition to 4th generation antigen/antibody testing?

1 Answer available

What is your approach to working up diarrhea in an immunocompromised patient?

1 Answer available

Do you typically adjust or hold immunosuppression in a well-controlled RA patient who is being treated for Mycobacterium avium-intracellulare (MAI)?

1 Answer available

What is your approach to starting antiretroviral therapy in a patient living with HIV who is diagnosed with cryptococcal meningitis?

1 Answer available

What else do you consider in the differential diagnosis for pulmonary-renal syndromes if there is low clinical and serologic evidence of AAV, Goodpasture's or other rheumatologic disease (SLE, RA, APS, Scleroderma)?

2 Answers available

Do you utilize post-vaccination IgG titers to detect common variable immunodeficiency in patients who are about to start or are actively on B cell depleting therapy?

2 Answers available

For AML patients, when do you stop antiinfective agents?

At the time of count recovery or do you continue it throughout induction and consolidation?

1 Answer available

Given recent data for use of doxycycline as post-exposure STD prophylaxis, how have you applied its use in clinical practice?

4 Answers available

For how long do you treat an early spinal hardware infection secondary to MSSA after operative washout and retention of hardware?

1 Answer available

Do you treat patients with HIV-AIDS and positive cryptococcal antigenemia but negative CSF cryptococcal antigen with standard meningitis treatment given the potential for the postzone effect?

1 Answer available

When should vaccines be given if not received prior to the start of high dose radiation (40-50 Gy) to the spleen?

1 Answer available

How do you manage a patient with severe RA or SLE that worsens after stopping immunosuppressants due to having chronic foot ulceration?

2 Answers available

Do you consider anti-viral prophylaxis in patients taking JAK inhibitors who have recurrent uncomplicated Zoster infection, but would prefer not changing therapy?

2 Answers available

What is your approach to vaccinations and titers for patients with myeloma, who are immunosuppressed and do not have appropriate antibody responses to vaccines?

E.g., for a patient with myeloma, s/p induction therapy, and high-dose chemotherapy, followed by autologous rescue with inappropriate antibody respons...

3 Answers available

What is your approach to determining the need for continued isolation in the dialysis unit for an ESKD patient who had a positive hepatitis B surface antigen one year ago but who now has a negative HbsAg in the absence of treatment?

1 Answer available

What is the recommended treatment regimen for Mycoplasma genitalium in a pregnant woman?

1 Answer available

Is there ever a role for the use of CMV immune globulin for treatment of CMV viremia and/or disease?

1 Answer available

How do you approach immunosuppression in patients with a positive Interferon Gamma Release Assay and prior intravesicular BCG treatment for bladder cancer?

Assuming no symptoms of TB, should patients be treated for latent TB prior to starting TNF inhibitors or other immunosuppressive agents?

1 Answer available

Do you treat Stenotrophomonas maltophilia bacteremia with combination therapy and if so, what is your preferred combination of antibacterials?

1 Answer available

For how long do you treat uncomplicated CRE bacteremia in an immunocompetent patient?

1 Answer available

What is your approach to monitoring patients with the indeterminate form of Chagas disease?

1 Answer available

Do you have a preference between Quantiferon Gold and T-spot TB for screening in patients starting immunosuppressive agents?

1 Answer available

Would you consider stepping down from an echinocandin to azole therapy prior to the end of an initial six-week course for fluconazole-susceptible Candida albicans endocarditis in the absence of valve surgery?

1 Answer available

Do you use letermovir as CMV prophylaxis in solid organ transplant patients?

1 Answer available

In patients taking biologics who are planning joint replacement and are known MRSA carriers do you perform decolonization prior to surgery?

0 Answers available

Given recent data from the REPRIEVE trial, how will you adapt your practice with regards to prescribing statins to patients living with HIV?

1 Answer available

How do you approach a well controlled HIV patient with diffuse cutaneous kaposi sarcoma who failed to respond to radiation, paclitaxel and monthly liposomal doxorubicin?

1 Answer available

Does management of NMDA receptor encephalitis change in a patient with HIV/AIDS?

1 Answer available

Would you anticoagulate a patient with splenic infarctions in the setting of CMV viremia?

If so, for how long?

1 Answer available

Are there instances when you do not recommend tunneled dialysis catheter exchange in patients on hemodialysis who are found to have bacteremia?

2 Answers available

How would you approach immunomodulatory treatment for systemic lupus associated protein losing enteropathy (PLE) in a patient whose clinical course has been complicated by significant infection?

Additionally, is it correct to assume that IV therapies might be preferred vs oral treatment given alterations in GI absorption in PLE?

1 Answer available

Are there any non-beta-lactam antibiotic options for treatment of neurosyphilis in non-pregnant adults?

1 Answer available

After a course of treatment for neurosyphilis, do you administer an additional IM dose of penicillin G one week after finishing the course of IV penicillin therapy?

1 Answer available

How long do you continue surveillance with imaging and sputum cultures in a patient with NTM with no indications for treatment?

3 Answers available

How would you approach the use of JAK inhibitors in a patient with stable RA who is now starting treatment for pulmonary MAC infection?

Patient previously failed abatacept and Rituximab.

1 Answer available

What is the risk of serious bacterial infection in a febrile solid tumor patient who has not yet started cancer-directed therapy and has normal cell counts with no central line?

1 Answer available

When would you consider percutaneous mechanical aspiration of vegetation in right-sided endocarditis?

1 Answer available

Does your approach to treating latent tuberculosis differ in a patient on anti-fibrotic therapy?

1 Answer available

Do you rule out TB in patients with AIDS and lobar pneumonia?

What’s your threshold to get the three AFBs and place the patient in airborne isolation?

1 Answer available

Do you routinely monitor imaging or pulmonary function in patients with pulmonary TB after the completion of therapy?

1 Answer available

What is the optimal timing for Zoster vaccine administration for a patient who recently recovered from herpes zoster infection and is now planning to start B-cell depletion therapy?

1 Answer available

How do you approach management of patients with active RA and recurrent non-severe C.diff?

(Patient with active RA despite hydroxychloroquine)

1 Answer available

How do you approach the workup for a patient with persistently elevated inflammatory markers (CRP and ESR) whose history and exam do not point to a clear cause?

4 Answers available

Do patients on eculizumab or ravulizumab require repeat vaccination against meningococcal infection after a certain interval?

1 Answer available

Are you using the microbial cell-free DNA “Karius” test to aid in the diagnosis of an atypical pulmonary infection such as PJP or NTM?

2 Answers available

Do you use steroids in patients with respiratory failure who are infected with both influenza and COVID-19?

How do you approach which risk to accept given that steroids have evidence for use in COVID-19 while is suggestion for harm in using steroids in influ...

1 Answer available

Do you routinely isolate and test for TB in a patient incidentally found to have a miliary pattern of nodules on chest CT?

2 Answers available

What is the antifungal prophylaxis regimen that you use in patients on peritoneal dialysis who are receiving antibiotics?

1 Answer available

What is your approach to therapy in patients with progressive Scedosporium pulmonary infection who are not candidates for surgical debridement?

1 Answer available

What is your approach to BK hemorrhagic cystitis not responding to cidofovir?

1 Answer available

How do you approach treatment of RA with methotrexate in a patient with treated Hepatitis C and normal liver function?

1 Answer available

Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

3 Answers available

Do you treat Candida spp isolated from a bronchoalveolar lavage?

1 Answer available

What topical or oral treatments do you recommend for patients with recurrent MRSA infections?

Do you recommend any changes to their personal hygiene practices? or changes to their environment?

1 Answer available

Would you consider prophylactic antifungal treatment prior to immunosuppressive therapies in a patient with previously treated pulmonary coccidiomycosis and residual parenchymal changes?

1 Answer available

Do you ever stop tobramycin prophylaxis in a patient with chronic bronchiectasis previously colonized with pseudomonas?

2 Answers available

Do you recommend IVIg and/or cytoreduction for patients with IgM MGUS with reciprocal depression in IgG and recurrent infections?

Infection is not part of the criteria for starting treatment both in UpToDate and in NCCN guidelines.

1 Answer available

Do you hold IV iron in the setting of active infection?

1 Answer available

Which medications have the lowest risk of tuberculosis reactivation in patients with uncertain tuberculosis history and active rheumatologic disease?

2 Answers available

What is your approach to the treatment of PML-IRIS in patients with HIV who have progressed to AIDS?

1 Answer available

How do you approach DMARD therapy in patients with rheumatoid arthritis and chronic hepatitis B?

Hepatitis screening labs revealing Hep B ag and core positivity with positive PCR

2 Answers available

How do you approach patients with onychomycosis that does not respond to terbinafine and prolonged courses of fluconazole?

Would you switch to itraconazole or perform fungal cultures? When would you consider repeating the course of treatment?

2 Answers available

How do you approach the timing of COVID-19 vaccination for patients with multiple sclerosis on B-cell depleting therapies?

3 Answers available

Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?

Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?

1 Answer available

Is there a role for regular hepatitis and TB screening in patients on chronic immunosuppressive therapy in the absence of new risk factors or exposures?

1 Answer available

What infectious prophylaxis do you use for patients with newly diagnosed multiple myeloma?

How do you decide how long to continue?

1 Answer available

How do you think about biologic use in patients with underlying HIV infection?

2 Answers available

Do you hold tocilizumab for patients who are diagnosed with Covid and are with mild to moderate symptoms or non-hospitalized?

1 Answer available

Is there a role for antibody testing to confirm vaccine response for patients on rituximab after COVID-19 vaccination?

1 Answer available

When would you consider checking JC virus prior to initiating biologic therapy?

1 Answer available

Do you routinely offer fungal prophylaxis for patients on BTK inhibitors?

Can experts comment on fungal pneumonia risk with individual BTK inhibitors as seen in ELEVATE-RR and whether this impacts their management decisions?

3 Answers available

How are you timing the third dose of the COVID-19 mRNA vaccine in patients on rituximab?

1 Answer available

How long would you treat with antimycobacterials before starting biologic DMARD in a patient with latent TB and active rheumatoid arthritis?

1 Answer available

In which patients with oncologic or hematologic disorders are you recommending a 3rd dose of mRNA COVID vaccine?

2 Answers available

How would you approach chronic isolated severe non-cyclic neutropenia with negative bone marrow and rheumatologic work-up?

Is there a role for empiric antibiotics if there is history of opportunistic infection?

1 Answer available

How would you manage an active rheumatoid arthritis patient on suppressive antibiotic therapy for ocular HSV who has abnormal liver function tests?

1 Answer available

Do you treat HIV/AIDS-associated CNS vasculitis with antiretrovirals alone or in combination with steroids?

1 Answer available

How would you recommend dosing the MMR or other live vaccines for patients with rheumatoid arthritis on immunosuppressive medications such as anti-TNF alpha therapy?

For example, healthcare workers who require these vaccines for employment

1 Answer available

How do you treat RA in patients with pulmonary mycobacterium avium complex (MAC) infections?

1 Answer available

Are there particular concerns related to the use of B-cell depletion therapies such as rituximab for rheumatic disease during the COVID-19 pandemic?

1 Answer available

How would you manage methotrexate therapy in an active rheumatoid arthritis patient undergoing treatment for latent TB with rifampin?

Do you stop methotrexate or adjust the dose?

1 Answer available

When are you recommending bone marrow transplant recipients receive the SARS-CoV-2 vaccine?

Does your recommendation differ between autologous and allogeneic transplants? Does your recommendation differ in allogeneic transplant recipients wh...

2 Answers available

How do you approach the evaluation of patients referred for chronic lyme disease and counsel patients regarding this entity?

1 Answer available

How does a history of splenectomy alter how you counsel patients on the infection risk of TNF inhibitors or other biologics?

1 Answer available

Are you recommending the mRNA COVID-19 vaccines to your patients with immune mediated inflammatory diseases?

5 Answers available

Which immunosuppressed patients with SLE would benefit from antibiotic prophylaxis to prevent pneumocystis pneumonia?

1 Answer available

Would you hold all immunosuppressive medications for the first month of LTBI treatment, or just biologics?

1 Answer available

How would you attempt to determine the etiology of intracranial hemorrhage in a patient with newly diagnosed lupus and an active viral infection?

1 Answer available

Do you avoid any specific biologic therapies in HIV positive patients?

1 Answer available

Should tuberculosis screening be performed before beginning methotrexate for treatment of rheumatoid arthritis?

1 Answer available

In what situations do you check for HIV status in your workup for inflammatory arthritis?

1 Answer available

What is your approach to dental prophylaxis for patients on biologics?

1 Answer available

How do you manage patients who are Hepatitis B core antibody positive/surface antigen negative and starting a biologic DMARD (other than rituximab)?

1 Answer available

During induction therapy for acute leukemia, when do you decide to discontinue the antimicrobial prophylaxis?

Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?

1 Answer available

Papers discussed in this category

The New England journal of medicine, 2007-01-25

Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.

Arthritis Rheumatol, 2016 Jan

2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.

Arthritis care & research, 2012-05

2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis.

Arthritis care & research, 2017-03

Rates of Serious Infections in HIV-Infected Patients Receiving Tumor Necrosis Factor Inhibitor Therapy for Concomitant Autoimmune Diseases.

Clin Exp Dermatol, 2018 May 24

Treatment of psoriasis with ustekinumab in a patient with HIV-related Kaposi sarcoma.

Blood, 2015-10-29

Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2008-10

Prophylactic antibiotic usage for Pneumocystis jirovecii pneumonia in patients with systemic lupus erythematosus on cyclophosphamide: a survey of US rheumatologists and the review of literature.

Clin Rheumatol, 2006 Dec 21

Rheumatol Int, 2020 Sep 18

High rates of severe disease and death due to SARS-CoV-2 infection in rheumatic disease patients treated with rituximab: a descriptive study.

N Engl J Med,

Clinical practice. Care of the asplenic patient.

Mediterr J Rheumatol, 2020 Jun 11

Infections in Patients with Rheumatoid Arthritis in the Era of Targeted Synthetic Therapies.

Clin Infect Dis,

Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011-03

Seroprotective titers against 2009 H1N1 influenza A virus after vaccination in allogeneic hematopoietic stem cell transplantation recipients.

Ann Rheum Dis, 2019 Aug 14

2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases.

Seminars in hematology, 2013-07

Evaluation and management of patients with isolated neutropenia.

Neurology, 2020 Jul 29

Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study.

Cells, 2018 Dec 28

Ocrelizumab Depletes CD20⁺ T Cells in Multiple Sclerosis Patients.

Arthritis Rheum,

Tuberculosis associated with therapy against tumor necrosis factor alpha.

Ann Oncol, 2021 Mar 18

Association of Clinical Factors and Recent Anti-Cancer Therapy with COVID-19 Severity among Patients with Cancer: A Report from the COVID-19 and Cancer Consortium.

J Clin Oncol, 2021 Jul 26

Acalabrutinib Versus Ibrutinib in Previously Treated Chronic Lymphocytic Leukemia: Results of the First Randomized Phase III Trial.

Journal of neurovirology, 2018-06

Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event.

Lancet Oncol, 2019 Oct 23

Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial.

Arthritis Care Res (Hoboken), 2021 Jul

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.

Clin Liver Dis (Hoboken), 2018 Aug 22

Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance.

Scientific reports, 2017 Aug 10

Analysis of Factors Influencing Diagnostic Accuracy of T-SPOT.TB for Active Tuberculosis in Clinical Practice.

Medical sciences (Basel, Switzerland), 2018-09-21

Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization.

The Journal of clinical investigation, 2021 Dec 15

The intersection of COVID-19 and autoimmunity.

Molecular systems biology, 2023 Mar 15

A methylation clock model of mild SARS-CoV-2 infection provides insight into immune dysregulation.

BMJ open, 2024 May 13

Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia.

Clin Microbiol Infect, 2018 Feb 07

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).

Urology, 1982-09

Prevention of cyclophosphamide-induced hemorrhagic cystitis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009-03

Intravesicular cidofovir for the management of BK virus-associated cystitis.

Clin Infect Dis, 2005 Jan 21

Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation.

Pediatr Transplant, 2014 Sep 08

Successful treatment of hemorrhagic cystitis after hematopoietic stem cell transplantation with intravesical hyaluronic acid.

J Clin Oncol, 2021 Apr 30

Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation.

Pediatr Infect Dis J, 2014 Nov

Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study.

Bone Marrow Transplant, 2006 Mar

Estrogen as treatment of hemorrhagic cystitis in children and adolescents undergoing bone marrow transplantation.

Perit Dial Int, 2022 Mar

ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment.

PET Clin, 2020 Feb 11

18F-Fluorodeoxyglucose PET/Computed Tomography in the Diagnosis and Monitoring of Giant Cell Arteritis.

Rheumatology (Oxford), 2022 Jul 22

PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis.

The Journal of thoracic and cardiovascular surgery, 2017-12

Contracts with people who inject drugs following valve surgery: Unrealistic and misguided expectations.

Tex Heart Inst J, 2022 Nov 1

Use of AngioVac Vacuum Aspiration for Refractory Endocarditis in a Postoperative Mustard Patient.

Circulation, 2020 Dec 17

2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Catheter Cardiovasc Interv, 2022 Jul 26

Treatment of cardiac device-related infective endocarditis utilizing the new T20 curve catheter and flow saver with the Inari mechanical aspiration system.

Multimed Man Cardiothorac Surg, 2020 Sep 25

Percutaneous aspiration of vegetation from tricuspid valve infective endocarditis.

JACC Case Rep, 2022 May 04

Case Series of Percutaneous Mechanical Aspiration of Mitral Valve Endocarditis.

Circulation, 2015 Sep 15

Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.

Arthritis & rheumatology (Hoboken, N.J.), 2017-10

The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: A Randomized Phase II Trial.

Ann Am Thorac Soc, 2017 May

Minimizing Tuberculosis Risk in Patients Receiving Anti-TNF Therapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-01

Late Infection-Related Mortality in Asplenic Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Human vaccines & immunotherapeutics, 2017 Feb

Blood, 2020 Jun 18

Tocilizumab in patients with symptomatic Kaposi sarcoma herpesvirus-associated multicentric Castleman disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019-01-18

Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus-associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial.

The New England journal of medicine, 2022 Mar 24

Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis.

The Cochrane database of systematic reviews, 2018 Jul 24

Early versus delayed antiretroviral treatment in HIV-positive people with cryptococcal meningitis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Jul 05

Early Antiretroviral Therapy Not Associated With Higher Cryptococcal Meningitis Mortality in People With Human Immunodeficiency Virus in High-Income Countries: An International Collaborative Cohort Study.

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 2021 Jul 23

Sexually Transmitted Infections Treatment Guidelines, 2021.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Sep 21

Are contact precautions "essential" for the prevention of healthcare-associated methicillin-resistant Staphylococcus aureus?

Journal of the Pediatric Infectious Diseases Society, 2024 Jan 03

Discontinuation of Contact Precautions for Methicillin-resistant Staphylococcus aureus in a Pediatric Healthcare System.

The Journal of infectious diseases, 2022 May 04

Recommendations for Screening and Diagnosis of Chagas Disease in the United States.

Arthritis Care Res (Hoboken), 2016 Jan

2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.

Alimentary pharmacology & therapeutics, 2022 May 20

Review article: latent tuberculosis in patients with inflammatory bowel diseases receiving immunosuppression-risks, screening, diagnosis and management.

Curr Opin Infect Dis, 2023 Aug 1

Neutropenia and antibiotics: when, what, how and why?

JAMA, 2023 Jul 03

Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017-11-29

Role of Secondary Prophylaxis With Valganciclovir in the Prevention of Recurrent Cytomegalovirus Disease in Solid Organ Transplant Recipients.

Annual review of medicine, 2022 Nov 04

Cytomegalovirus Therapy: Role of Letermovir in Prophylaxis and Treatment in Transplant Recipients.

The Annals of thoracic surgery, 2017 Feb 04

Surgical Versus Medical Therapy for Prosthetic Valve Endocarditis: A Meta-Analysis of 32 Studies.

European heart journal, 2023 Oct 14

2023 ESC Guidelines for the management of endocarditis.

The Annals of thoracic surgery, 2016-06

Rifampin for Surgically Treated Staphylococcal Infective Endocarditis: A Propensity Score-Adjusted Cohort Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021 May 04

Is Rifampin Use Associated With Better Outcome in Staphylococcal Prosthetic Valve Endocarditis? A Multicenter Retrospective Study.

JAMA network open, 2022 Dec 01

Association of Linezolid With Risk of Serotonin Syndrome in Patients Receiving Antidepressants.

International journal of antimicrobial agents, 2023 Jun 08

Dose optimisation of linezolid in critically ill patients based on a population pharmacokinetic model: A two-centre prospective interventional study.

Pharmacy (Basel, Switzerland), 2023 Nov 20

The Association of Serotonin Toxicity with Combination Linezolid-Serotonergic Agent Therapy: A Systematic Review and Meta-Analysis.

International journal of antimicrobial agents, 2023 May 07

Real-world evaluation of linezolid-associated serotonin toxicity with and without concurrent serotonergic agents.

JAMA network open, 2024 Jan 02

Early Switch From Intravenous to Oral Antibiotics for Patients With Uncomplicated Gram-Negative Bacteremia.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2023 Nov 24

Treatment guidelines for multidrug-resistant Gram-negative microorganisms.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2023 Oct 26

In vitro activity of cefiderocol and other newly approved antimicrobials against multi-drug resistant Gram-negative pathogens recovered in intensive care units in Spain and Portugal.

EClinicalMedicine, 2022 Dec 01

Duration of antibiotic treatment for Gram-negative bacteremia - Systematic review and individual participant data (IPD) meta-analysis.

Journal of clinical pharmacy and therapeutics, 2020 Sep 27

Short-course versus long-course antibiotic treatment in patients with uncomplicated gram-negative bacteremia: A systematic review and meta-analysis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019 Sep 13

Seven Versus 14 Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia: A Noninferiority Randomized Controlled Trial.

European heart journal, 2023 Oct 25

Clinical implementation of partial oral treatment in infective endocarditis: the Danish POETry study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2023 May 11

Choosing patients over placebos: oral transitional therapy vs. IV-only therapy for bacteraemia and infective endocarditis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Jul 26

Attainment of Target Antibiotic Levels by Oral Treatment of Left-Sided Infective Endocarditis: A POET Substudy.

Infectious diseases and therapy, 2022 May 03

Legionnaires' Disease: Update on Diagnosis and Treatment.

American journal of respiratory and critical care medicine, 2019 Oct 01

Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America.

The New England journal of medicine, 2023 Apr 06

Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.

The Journal of antimicrobial chemotherapy, 2021 Jun 18

Clinical and serological outcomes in patients treated with oral doxycycline for early neurosyphilis.

Sexually transmitted diseases, 1993 Nov-Dec

Asymptomatic neurosyphilis after doxycycline therapy for early latent syphilis.

Medicine, 2014 Oct

Intravenous immunoglobulin in the therapeutic armamentarium of systemic lupus erythematosus: a systematic review and meta-analysis.

Arthritis and rheumatism, 2013-07

Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio.

Rheumatology international, 2011 Feb 23

Lupus protein-losing enteropathy (LUPLE): a systematic review.

Arthritis & rheumatology (Hoboken, N.J.), 2023 Jun 01

Comparative Risks of Infection With Belimumab Versus Oral Immunosuppressants in Patients With Nonrenal Systemic Lupus Erythematosus.

Arthritis care & research, 2016 Jan

Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lupus, 2014 Feb 06

Vitamin D and cutaneous lupus erythematosus: effect of vitamin D replacement on disease severity.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009-07-01

Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America.

Journal of medical case reports, 2014 Mar 04

Cytomegalovirus-associated splenic infarcts in an adult immune-competent man: a case report and review of the literature.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-12

Pomalidomide for Symptomatic Kaposi's Sarcoma in People With and Without HIV Infection: A Phase I/II Study.

The Lancet. Oncology, 2022 Mar 10

PD-1 blockade with pembrolizumab in classic or endemic Kaposi's sarcoma: a multicentre, single-arm, phase 2 study.

Journal of translational internal medicine, 2019 Dec 31

Influenza Vaccination and Guillain-Barré Syndrome: Reality or Fear.

Journal of oncology practice, 2018-09-04

Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update Summary.

Leukemia & lymphoma, 2022 Mar 15

Outcomes of antifungal prophylaxis for newly diagnosed AML patients treated with a hypomethylating agent and venetoclax.

Hematology. American Society of Hematology. Education Program, 2020 Dec 04

Updates in infection risk and management in acute leukemia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Sep 18

Considerations and Concerns regarding the use of Ertapenem in Patients with Hypoalbuminemia: is it Truly Inappropriate?

Infection control and hospital epidemiology, 2018-02

Duration of Contact Precautions for Acute-Care Settings.

Antimicrobial stewardship & healthcare epidemiology : ASHE, 2021 Oct 21

Taking off the gown: Impact of discontinuing contact precautions for extended-spectrum β-lactamase (ESBL)-producing organisms.

American journal of infection control, 2023 Feb 01

Increased evidence for no benefit of contact precautions in preventing extended-spectrum -lactamases-producing Enterobacteriaceae: Systematic scoping review.

Current opinion in rheumatology, 2018 Jul

Trimethoprim-sulfamethoxazole and antineutrophil cytoplasmic antibodies-associated vasculitis.

European journal of medical research, 2009 Dec 07

Co-trimoxazole and prevention of relapses of PR3-ANCA positive vasculitis with pulmonary involvement.

Annals of the rheumatic diseases, 2018 Jun 27

Trimethoprim-sulfamethoxazole prophylaxis prevents severe/life-threatening infections following rituximab in antineutrophil cytoplasm antibody-associated vasculitis.

The Lancet. Infectious diseases, 2024 Jan 17

Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial.

JAMA ophthalmology, 2017 Dec 01

Clinical Features and Outcomes of Patients With Tubercular Uveitis Treated With Antitubercular Therapy in the Collaborative Ocular Tuberculosis Study (COTS)-1.

Journal of the American College of Cardiology, 2023 Jan 31

Infective Endocarditis After Transcatheter Aortic Valve Replacement: JACC State-of-the-Art Review.

JACC. Cardiovascular interventions, 2022 Jun 13

Long-Term Follow-Up of Hypoattenuated Leaflet Thickening After Transcatheter Aortic Valve Replacement.

JACC. Cardiovascular imaging, 2017 Aug 16

Diagnosis of Infective Endocarditis After TAVR: Value of a Multimodality Imaging Approach.

The New England journal of medicine, 2018 Aug 28

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Sep 11

Real-World Application of Oral Therapy for Infective Endocarditis: A Multicenter, Retrospective, Cohort Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015-08-01

Histoplasmosis complicating tumor necrosis factor-α blocker therapy: a retrospective analysis of 98 cases.

N Engl J Med, 2023 Mar 21

Hydrocortisone in Severe Community-Acquired Pneumonia.

Journal of ophthalmic inflammation and infection, 2015-12

Clinical and laboratory characteristics of ocular syphilis: a new face in the era of HIV co-infection.

JAMA ophthalmology, 2024 Jan 01

Rising Incidence of Syphilitic Uveitis-Related Hospitalizations in the US.

Investigative ophthalmology & visual science, 2016 Feb

Clinical Manifestations and Outcome of Syphilitic Uveitis.

Ophthalmology. Retina, 2019 Mar 21

International Practice Patterns for the Management of Acute Postsurgical and Postintravitreal Injection Endophthalmitis: European Vitreo-Retinal Society Endophthalmitis Study Report 1.

Retina (Philadelphia, Pa.), 2021 Feb 01

VISUAL OUTCOME OF EARLY VITRECTOMY AND INTRAVITREAL ANTIBIOTICS IN ACUTE POSTSURGICAL AND POSTINTRAVITREAL INJECTION ENDOPHTHALMITIS: European Vitreo-Retinal Society Endophthalmitis Study Report Two.

Archives of ophthalmology (Chicago, Ill. : 1960), 1995 Dec

Results of the Endophthalmitis Vitrectomy Study. A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Endophthalmitis Vitrectomy Study Group.

Infection control and hospital epidemiology, 2018-05

Time to Detection in Culture Supports Prediction of Low Transmissibility of Tuberculosis and Discontinuation of Isolation for Low-Risk Patients With A Single AFB-Negative and NAAT-Negative Respiratory Specimen.

Clinical microbiology reviews, 2018-10

Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.

JAMA internal medicine, 2018-10-01

Association of Rapid Molecular Testing With Duration of Respiratory Isolation for Patients With Possible Tuberculosis in a US Hospital.

American journal of respiratory and critical care medicine, 2021 Jan 15

The Epidemiological Importance of Subclinical Tuberculosis. A Critical Reappraisal.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024 Apr 18

NTCA Guidelines for Respiratory Isolation and Restrictions to Reduce Transmission of Pulmonary Tuberculosis in Community Settings.

The New England journal of medicine, 2024 Apr 04

Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19.

The Journal of infectious diseases, 1980 Mar

A study of cephalothin and desacetylcephalothin in cerebrospinal fluid in therapy for experimental pneumococcal meningitis.

Antimicrobial agents and chemotherapy, 1976 Sep

Pharmacological study of cefazolin during intermittent and continuous infusion: a crossover investigation in humans.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020 May 08

Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis.

The Lancet. Infectious diseases, 2020 Dec 14

Effectiveness of adjunctive clindamycin in β-lactam antibiotic-treated patients with invasive β-haemolytic streptococcal infections in US hospitals: a retrospective multicentre cohort study.

Open forum infectious diseases, 2023 Nov 24

Comparison of Adjuvant Clindamycin vs Linezolid for Severe Invasive Group A Skin and Soft Tissue Infections.

The American journal of medicine, 1992-11

Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017 Oct 30

A Multicenter Study Evaluating Ceftriaxone and Benzathine Penicillin G as Treatment Agents for Early Syphilis in Jiangsu, China.

Open forum infectious diseases, 2024 Mar 13

Syphilis Treatment: Systematic Review and Meta-Analysis Investigating Nonpenicillin Therapeutic Strategies.

Circulation, 2008 Jun 09

Bacteremia associated with toothbrushing and dental extraction.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 1999 May-Jun

Prophylactic antibiotic therapy prior to dental treatment for patients with end-stage renal disease.

Nephrology (Carlton, Vic.), 2004 Jun

Antibiotic prophylaxis in dialysis patients undergoing invasive dental treatment.

International ophthalmology clinics, 2022 Apr 01

Challenges and Updates on the Management of Acute Retinal Necrosis.

Clinical ophthalmology (Auckland, N.Z.), 2020 Jul 08

Management Strategies of Acute Retinal Necrosis: Current Perspectives.

Retinal cases & brief reports, 2022 Nov 01

RECURRENT ACUTE RETINAL NECROSIS.

Open forum infectious diseases, 2024 May 02

Should Blood Cultures Be Drawn Through an Indwelling Catheter?

Lancet (London, England), 2021 Mar 27

Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial.

Lancet (London, England), 2021 Mar 27

How low can we go in community-acquired pneumonia therapy?

World journal of urology, 2013 Apr 30

D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial.

JAMA internal medicine, 2024 Apr 08

d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial.

The Cochrane database of systematic reviews, 2022 Aug 30

D-mannose for preventing and treating urinary tract infections.

JAMA internal medicine, 2024 May 13

Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019-05-30

Oral Vancomycin Prophylaxis Is Highly Effective in Preventing Clostridium difficile Infection in Allogeneic Hematopoietic Cell Transplant Recipients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Aug 22

Effectiveness of Oral Vancomycin for Prevention of Healthcare Facility-Onset Clostridioides difficile Infection in Targeted Patients During Systemic Antibiotic Exposure.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Oct 23

Oral Vancomycin Prophylaxis for Clostridioides difficile in High-Risk Patients Receiving Systemic Antibiotics: What Exactly Are We Preventing?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Aug 22

Perils, Pitfalls, and Promise of Primary Prophylaxis for Clostridioides difficile Infection.

BMJ open, 2023 Sep 13

Evaluation of the effectiveness and safety of oral vancomycin versus placebo in the prevention of recurrence of infection in patients under systemic antibiotic therapy: a phase III, randomised, double-blind clinical trial.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2019 Jun 27

Oral Vancomycin Prophylaxis as Secondary Prevention Against Clostridioides difficile Infection in the Hematopoietic Stem Cell Transplantation and Hematologic Malignancy Population.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018-05-17

Detecting Infections Rapidly and Easily for Candidemia Trial, Part 2 (DIRECT2): A Prospective, Multicenter Study of the T2Candida Panel.

The Annals of pharmacotherapy, 2023 Mar 22

Therapeutic Options for Adult Patients With Persistent Methicillin-Susceptible Bacteremia: A Narrative Review.

Diagnostic microbiology and infectious disease, 2021 Jul 24

Clinical outcomes of combination versus monotherapy for gram negative non-HACEK infective endocarditis.

Open forum infectious diseases, 2023 Feb 02

Epidemiology and Clinical Outcomes of Non-HACEK Gram-Negative Infective Endocarditis.

Infection & chemotherapy, 2021 Jun

Risk of Endogenous Endophthalmitis during Bacteremia: Implications for Screening.

Retina (Philadelphia, Pa.), 2014 Sep

Endophthalmitis caused by Klebsiella species.

Eye (London, England), 2017 Jun 16

Clinical features and prognostic factors of Klebsiella endophthalmitis-10-year experience in an endemic region.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006-07-15

Do follow-up imaging examinations provide useful prognostic information in patients with spine infection?

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2021 Jul 22

The ERACE-PA Global Surveillance Program: Ceftolozane/tazobactam and Ceftazidime/avibactam in vitro Activity against a Global Collection of Carbapenem-resistant Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy, 2023 Jul 05

Ceftolozane-Tazobactam Versus Ceftazidime-Avibactam for the Treatment of Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa: a Multicenter Cohort Study.

The Lancet. Neurology, 2009-08

Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment.

Circulation, 2023 Dec 04

Update on Cardiovascular Implantable Electronic Device Infections and Their Prevention, Diagnosis, and Management: A Scientific Statement From the American Heart Association: Endorsed by the International Society for Cardiovascular Infectious Diseases.

The Journal of infection, 2011-11

Norovirus gastroenteritis successfully treated with nitazoxanide.

Alimentary pharmacology & therapeutics, 2006 Nov 15

Nitazoxanide in the treatment of viral gastroenteritis: a randomized double-blind placebo-controlled clinical trial.

Journal of tropical medicine, 2017 Feb 26

Nitazoxanide in Acute Rotavirus Diarrhea: A Randomized Control Trial from a Developing Country.

Lupus, 2014 Jul 30

Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections.

MMWR. Morbidity and mortality weekly report, 2024 Sep 12

Use of 21-Valent Pneumococcal Conjugate Vaccine Among U.S. Adults: Recommendations of the Advisory Committee on Immunization Practices - United States, 2024.

Journal of fungi (Basel, Switzerland), 2019 Sep 04

A Week of Oral Terbinafine Pulse Regimen Every Three Months to Treat all Dermatophyte Onychomycosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024 Jul 19

Oral Antibiotics for Treatment of Gram-Negative Bacteremia in Solid Organ Transplant Recipients: A Propensity Score Weighted Retrospective Observational Study.

The American journal of medicine, 2024 Mar 16

The Contribution of 18F FDG PET-CT for the Investigation of Fever of Unknown Origin and Inflammation of Unknown Origin.

The New England journal of medicine, 1987-03-05

Accelerated loss of antibody to hepatitis B surface antigen among immunodeficient homosexual men infected with HIV.

Hepatology (Baltimore, Md.), 2018 Apr

Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Dec 31

Global Burden of Hepatitis B Infection in People Living With Human Immunodeficiency Virus: A Systematic Review and Meta-analysis.

Journal of viral hepatitis, 2019 Dec 22

Prevalence and burden of HBV co-infection among people living with HIV: A global systematic review and meta-analysis.

Topics in antiviral medicine, 2023 Mar 31

Chronic hepatitis B and HIV coinfection.

Journal of acquired immune deficiency syndromes (1999), 2023 Oct 01

Brief Report: Hepatitis B Infection or Reactivation After Switch to 2-Drug Antiretroviral Therapy: A Case Series, Literature Review, and Management Discussion.

American journal of respiratory and critical care medicine, 2019 Nov 15

Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.

Radiother Oncol, 2015 Aug 04

Radiation-induced dose-dependent changes of the spleen following postoperative chemoradiotherapy for gastric cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024 Mar 18

Vaccination of Adults With Cancer: ASCO Guideline.

American journal of clinical oncology, 2021 Aug 01

Outcomes of Immune Checkpoint Inhibitor-related Diarrhea or Colitis in Cancer Patients With Superimposed Gastrointestinal Infections.

Annals of gastroenterology, 2022 Jun 02

infection in cancer patients receiving immune checkpoint inhibitors.

Melanoma research, 2023 Mar 27

Clostridium difficile infection and immune checkpoint inhibitor-induced colitis in melanoma: 18 cases and a review of the literature.

Journal of clinical microbiology, 2007-11

Detection of bloodstream infections in adults: how many blood cultures are needed?

Journal of clinical microbiology, 2011-12

Optimized pathogen detection with 30- compared to 20-milliliter blood culture draws.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004 May 25

Optimal testing parameters for blood cultures.

Open forum infectious diseases, 2021 Dec 18

Clinical Significance of in a Single Positive Blood Culture Bottle.

Journal of the American College of Cardiology, 2019 Jul 16

Prevalence of Infective Endocarditis in Enterococcus faecalis Bacteremia.

American journal of infection control, 2020 Jun 02

Cautious handling of urine from moderate to severe COVID-19 patients.

Osong public health and research perspectives, 2020 Feb

Identification of Coronavirus Isolated from a Patient in Korea with COVID-19.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Nov 05

Orally Administered Human Immunoglobulin Therapy for Norovirus Enteritis in Solid Organ Transplant Recipients: A Case Series at a Single Academic Transplant Center.

Clinical transplantation, 2022 Jan 20

Nitazoxanide treatment for norovirus infection in solid organ transplant recipients.

The Journal of infectious diseases, 2007-12-15

Decreased adherence to antiretroviral therapy observed prior to transient human immunodeficiency virus type 1 viremia.

AIDS (London, England), 2021 Nov 01

HIV-1 viral blips are associated with repeated and increasingly high levels of cell-associated HIV-1 RNA transcriptional activity.

Current HIV/AIDS reports, 2023 Nov 13

Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1994-05

Measurement of cryptococcal antigen in serum and cerebrospinal fluid: value in the management of AIDS-associated cryptococcal meningitis.

HIV clinical trials, 2000

Clinical utility of monitoring serum cryptococcal antigen (sCRAG) titers in patients with AIDS-related cryptococcal disease.

Journal of clinical microbiology, 2005 Nov

The role of cryptococcal antigen assay in diagnosis and monitoring of cryptococcal meningitis.

Infectious Disease

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