Infectious Disease   

Questions discussed in this category



A patient on meloxicam for LBP developed high, persistent fevers and no other symptoms. An IGRA, among many tests, was sent. The IGRA’s mitogen ...

Would you send a CMV DNA PCR in blood, and if you elect to treat with anti-CMV medication, how long would you treat and what parameters would you use,...

Are you aware of any data regarding relative risk of molluscum contagiosum infection in reference to DMARDs/biologics?

Data on the role of steroids in HIV negative patients with PJP has been conflicting.

Is parasitemia >10% and severe hemolysis with Hb less than 7 enough to initiate this?

Assuming patient already received an initial course of antibiotic treatment in response to a positive urine culture during routine screening early in ...

The ESC guidelines recommend obtaining at least three sets of blood cultures at 30-minute intervals before starting antibiotic therapy, each with 10 m...

Chemotherapy is associated with acquiring C diff colitis. Does immunotherapy share that same risk and necessitate ruling out infection prior to anti-d...

Do you empirically treat itchy patients -with a non specific rash- for scabies without obvious clinical findings for scabies? 

Do the results of the recent study (Misset et al., PMID 37889107) showing reduction in 28-day mortality in patients with high neutralizing antibody ti...

Is there a role for oral vancomycin in these patients, or is oral vancomycin redundant if other routes of administration are being used (i.e intracolo...

Is there a role for oral antiviral therapy alone (as opposed to induction with IV) and for what duration? And is there a role for ongoing suppressive ...

Especially in light of the results of the randomized clinical trial published on 8/2024 in Jama Internal Medicine by Hayward et al., PMID 38587819.

Is there a role for booster vaccination and if so, how do you approach the timing when a patient is already on a biologic for immunosuppression? 

Since the COVID-19 pandemic, increasingly we see management of acute cholecystitis with cholecystostomy tubes as opposed to surgery, even amongst pati...

If yes, would you go with Zidovudine monotherapy versus combining with interferon-alpha? And what would be the preferred dose and duration? 

How do you approach ongoing screening for TB in patients with history of treated latent TB, but have ongoing use of DMARDs and/or biologics given quan...

At the time of count recovery or do you continue it throughout induction and consolidation?

E.g., for a patient with myeloma, s/p induction therapy, and high-dose chemotherapy, followed by autologous rescue with inappropriate antibody respons...

Assuming no symptoms of TB, should patients be treated for latent TB prior to starting TNF inhibitors or other immunosuppressive agents?

What’s your threshold to get the three AFBs and place the patient in airborne isolation?

How do you approach which risk to accept given that steroids have evidence for use in COVID-19 while is suggestion for harm in using steroids in influ...

Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?

Do you recommend any changes to their personal hygiene practices? or changes to their environment?

Infection is not part of the criteria for starting treatment both in UpToDate and in NCCN guidelines. 

Hepatitis screening labs revealing Hep B ag and core positivity with positive PCR

Would you switch to itraconazole or perform fungal cultures? When would you consider repeating the course of treatment? 

Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?

Can experts comment on fungal pneumonia risk with individual BTK inhibitors as seen in ELEVATE-RR and whether this impacts their management decisions?

Does your recommendation differ between autologous and allogeneic transplants? Does your recommendation differ in allogeneic transplant recipients wh...

Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?


Papers discussed in this category


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