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Questions discussed in this category


What if there is continued thrombocytopenia despite reaching complete remission (with incomplete marrow recovery)?

Received dexamethasone 40 mg daily x4 and IVIG without response. No DIC. PB flow cytometry and bone marrow biopsy without pathology. Are there specifi...

Such as the case in which a patient is unresponsive to steroids, IVIG, TPO-agonist, rituximab, splenectomy, and even fostamitinib.

For example, do we prefer one regimen over the other in patients with a bleeding history or who have relapsed after a lengthy remission?

Would you consider high-dose dexamethasone (deliberating adverse effects of antenatal steroids) or move to next-line therapies?


Papers discussed in this category


The New England journal of medicine, 2013-02-21

The New England journal of medicine, 2017 Mar 18