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Pediatric Hematology/Oncology
Thrombocytopenia
Questions discussed in this category
How do you approach an ITP patient who responds very well to steroids but the response is short-lived?
How would you counsel the patient if he/she wants to continue on steroids?
3 Answers available
How do you approach anticoagulation in the setting of HIT and thrombocytopenia?
I.e. platelet count <30. Would your management change if HIT were only suspected rather than confirmed?
1 Answer available
How do you approach a persistently elevated mean platelet volume and immature platelet fraction in an otherwise healthy patient with a normal platelet count?
Provided that the platelet count is normal, do you usually consider this to be a potential erroneous result or do you pursue additional workup for RBC...
1 Answer available
When should you use caplacizumab in the treatment of acute TTP patients?
1 Answer available
Is there a correlation between spleen size and degree of thrombocytopenia?
1 Answer available
How do you approach very treatment-refractory ITP?
Such as the case in which a patient is unresponsive to steroids, IVIG, TPO-agonist, rituximab, splenectomy, and even fostamitinib.
1 Answer available
How do you approach a patient with chronic low ADAMTS13 activity and low level of inhibitor without signs of thrombocytopenia or hemolysis?
ADAMTS13 level <5% Inhibitor level <1
1 Answer available
How do you explain TTP to patients?
1 Answer available
Based on recent data would you consider adding ATRA to low dose rituximab for steroid refractory ITP?
Wu et al., PMID 34665865
1 Answer available
At what platelet count would you feel comfortable dosing aspirin 81 mg for coronary artery disease in a patient with ITP?
Presuming strong indication for ASA - eg history of NSTEMI
1 Answer available
How do you manage drug-induced thrombocytopenia when the implicated drug is essential?
e.g. DITP from eptifibatide after a cardiac intervention
1 Answer available
For treatment of ITP, what would you add to dexamethasone to achieve the fastest recovery in a patient waiting for a procedure?
IVIG, TPO, or other agents?
1 Answer available
Do you routinely check platelet counts after COVID-19 vaccines in patients with chronic ITP?
1 Answer available
How long do you continue caplacizumab in relapsed refractory TTP?
How often do you monitor ADAMTS-13 levels off therapy?
1 Answer available
Are there any reasons to consider a prolonged course of steroids with taper over a shorter course of pulsed steroids in the treatment of ITP?
For example, do we prefer one regimen over the other in patients with a bleeding history or who have relapsed after a lengthy remission?
1 Answer available
When (if ever) do you check for anti-platelet antibodies for workup of thrombocytopenia?
1 Answer available
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Papers discussed in this category
Blood, 2021 Apr 01
Real-world experience with caplacizumab in the management of acute TTP.
Blood, 2018 Sep 10
Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura.
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