Pulmonology

Questions discussed in this category

How do you screen rheumatoid arthritis patients for lung disease (modality, frequency, patient selection)?

This question is part of our collaboration with ACR Convergence 2024 to Continue the Conversation from the meeeting. This question was inspired by the...

4 Answers available

Is there any utility to trending Histoplasma serology titers to guide duration of therapy or treatment response for pulmonary histoplasmosis with negative urine antigen?

2 Answers available

What duration of antibiotic therapy do you use for a loculated parapneumonic effusion that does not meet criteria for empyema?

3 Answers available

How do you approach management of osteoporosis in patients post lung transplant?

1 Answer available

Do you recommend procalcitonin to help convince other providers to stop antibiotics in patients with pneumonia in whom a non-infectious diagnosis is strongly suspected?

2 Answers available

How often do you monitor pulmonary function tests in patients with fibrotic lung disease?

1 Answer available

At what age do you stop LDCT chest for lung cancer screening?

USPTF and CMS guidelines differ in age criteria, and NCCN guidelines do not have an upper age limit.

2 Answers available

How do you manage persistent insomnia despite ASV titration in patients with complex sleep apnea?

1 Answer available

What criteria do you use to decide when to perform a BAL in hypersensitivity pneumonitis?

Do you perform it on every suspected case, or are there specific indications you look for before proceeding with BAL?

2 Answers available

Which patient characteristics or scenarios drive you to choose tezepelumab over dupilumab for asthma?

3 Answers available

What is your approach to the use of Paxlovid for patients with risk factors for severe Covid-19 infection but who have received SARS-CoV-2 vaccines in light of the EPIC-SR trial findings?

EPIC-SR Trial

3 Answers available

Do you grade severity of OSA by AHI or RDI?

5 Answers available

How well does a negative non-contrast MRI of the brain exclude metastasis in a patient with squamous cell carcinoma of the lung?

2 Answers available

How do you approach PJP prophylaxis in patients with rheumatic disease on corticosteroids?

Does the presence of ILD change your approach?

3 Answers available

What further evaluation do you pursue for patients who present with vague symptoms such as subjective fevers or intermittent night sweats, who have no pulmonary symptoms but have a positive IGRA?

1 Answer available

How would you treat an asymptomatic patient with a positive Blastomyces antibody, evidence of prior granulomatous lung disease on imaging, and who may require immunosuppression in the future?

1 Answer available

Is there a role for dual antibiotic treatment with ethambutol and macrolide only, as opposed to three-drug antibiotic therapy, in the treatment of treatment-naive pulmonary MAC without cavitary disease?

3 Answers available

For patients with newly diagnosed VTE on IV heparin planned for transition to DOAC, would you start at the loading or maintenance DOAC dose?

If they have been on IV heparin for 3 days, for example, would you subtract those days from the recommended loading dose time?

3 Answers available

How do you approach managing clozapine in patients who are critically ill?

1 Answer available

How do you sequence pharmacologic treatments for primary insomnia?

5 Answers available

How do you decide between oral vs nasal route of entry for bronchoscopy with BAL with moderate sedation?

3 Answers available

How do you determine which patients with ANCA associated vasculitis may be good candidates for reduced dose glucocorticoid tapering?

This question is part of our collaboration with ACR Convergence 2024 to Continue the Conversation from the meeeting. This question was inspi...

1 Answer available

How small of a nodule would you attempt to biopsy with robotic bronchoscopy?

1 Answer available

Do you perform routine interval screening for pulmonary fibrosis in individuals who have been identified through genetic testing as being at risk for developing pulmonary fibrosis but don't exhibit any signs or symptoms?

Specifically considering individuals with known mutations in MUC5B, TERT/TERC, etc

2 Answers available

What is your preferred third antimicrobial agent for a patient with treatment-naive pulmonary MAC without cavitary disease and strict contraindications to utilization of rifampin or rifabutin?

3 Answers available

What approaches can we take to initiate therapy and improve survival rates in patients with HLH?

2 Answers available

What is your approach to treatment of airway involvement, such as recurrent bronchial stenosis, in relapsing polychondritis?

Are there specific immunosuppressive agents effective for this manifestation?

1 Answer available

What is the duration of steroids that you prescribe for organizing pneumonia?

1 Answer available

What has been your stepwise approach to oxygenation, including when to consider the use of inhaled nitric oxide or epoprostenol, in refractory hypoxemia due to cardiogenic pulmonary edema in patients who are otherwise not ECMO candidates?

1 Answer available

What is the interpretation of two IGRAs with negative mitogen wells, in the absence of immunosuppression?

A patient on meloxicam for LBP developed high, persistent fevers and no other symptoms. An IGRA, among many tests, was sent. The IGRA’s mitogen ...

2 Answers available

How soon would you repeat PET/CT in a patient with cardiac sarcoid after starting treatment with infliximab?

Pre-treatment troponin was mildly elevated, while ILR2 receptor, ACE, CRP, ESR were normal.

1 Answer available

In a patient with severe hyponatremia and acute kidney injury in the setting of hypovolemic shock, would fluid resuscitation take precedence over the rate at which sodium is corrected?

3 Answers available

Which biomarkers or diagnostic tools do you prioritize to support the decision to start antifungal treatment in septic patients with no clear source of infection but at high risk for fungal infections?

2 Answers available

Do you favor timely bronchoscopy for diagnostics over close surveillance in mildly symptomatic patients with CT findings suspicious for NTM infection who are not able to expectorate?

4 Answers available

What is your approach to helping parents manage sleep disturbances in patients with autism spectrum disorder?

1 Answer available

How would you manage symptomatic, bilateral subsegmental PE developed after long air travel?

The patient takes frequent flights for their job, with no prior history of VTE, and has already been taking measures for prevention including frequent...

2 Answers available

Do add a macrolide for immunomodulatory effect in patients with macrolide-resistant M. abscessus?

2 Answers available

Do you use steroids in the management of PJP pneumonia with severe hypoxia in HIV negative patients?

Data on the role of steroids in HIV negative patients with PJP has been conflicting.

2 Answers available

Do you avoid use of inhalers with milk protein in patients with a milk allergy?

1 Answer available

Do you use or recommend clinical severity scores or other parameters in helping prognostication in patients with refractory status epilepticus?

1 Answer available

What is your hemoglobin target for PRBC transfusion in cases of acute brain injury?

Have recent trials (TRAIN trial and HEMOTION trial) influenced your approach?

1 Answer available

What is your approach to evaluation and management of GERD in a patient with IPF?

1 Answer available

What are some important considerations for use of ACE inhibition in scleroderma renal crisis patients who require dialysis?

For example, is captopril dialyzable?

1 Answer available

What is your preferred first-line treatment for chronic fatigue in patients with long COVID-19?

7 Answers available

Do you recommend early oral nutrition when managing diabetic ketoacidosis?

Some data showed early enteral nutrition improves outcomes in DKA. Some thought that enteral nutrition could counteract the insulin gtt.

1 Answer available

Would you offer lung SBRT in a patient with Pulmonary Langerhans Cell Histiocytosis (PLCH)?

1 Answer available

Will you incorporate ensifentrine in the treatment regimen of patients with COPD on baseline dual or triple inhaler therapy?

1 Answer available

Would you use the pneumococcal conjugate-21 vaccine (Capvaxive) instead of the conjugate-20 (Prevnar-20) for routine vaccinations in immunosuppressed patients?

2 Answers available

Do shorter door-to-balloon (D2B) times impact outcomes in STEMI, if it's already less than 90 minutes, and to what degree (i.e., 30 vs 60 minutes would have a more significant impact)?

1 Answer available

Do you consider the use of tocilizumab in patients with COVID pneumonia who have had an improvement in supplemental O2 requirements but have significantly elevated inflammatory markers after day two of remdesivir and dexamethasone?

1 Answer available

What is your approach to differentiating RA-ILD from medication toxicity (I.e. from methotrexate)?

1 Answer available

Do you routinely perform a pre-extubation bronchoscopy for secretion clearance during the index hospitalization in patients following lung transplantation?

2 Answers available

What is your diagnostic approach to patients referred for central sleep apnea on PSG but normal overnight EEG and MRI?

1 Answer available

What is your blood pressure or mean arterial pressure goal in a critically ill patient with acute kidney injury?

1 Answer available

What strategies do you use to prevent overcorrection of serum sodium in patients with severe hyponatremia and adrenal insufficiency when initiating glucocorticoid therapy?

1 Answer available

Are there clinical scenarios in which you would start empiric treatment for pulmonary TB without microbiologic confirmation?

2 Answers available

Are you using genomic classifiers to diagnose UIP when imaging is indeterminate or suggestive of an alternate diagnosis?

4 Answers available

Is it necessary to prescribe a steroid taper after two weeks of high-dose prednisone (60 mg daily)?

4 Answers available

Do you consider tracheostomy for the management of continued hypercapnea despite compliance with PAP in patients with OHS and OSA?

2 Answers available

Have you adopted the use of low dose morphine for treatment of cough in patients with IPF?

If so, what dose and formulation of morphine do you prefer?The PACIFY COUGH trial utilized controlled-release morphine 5 mg BID, however the lowest do...

1 Answer available

What is your approach to evaluation and diagnosis following a non-diagnostic MSLT in a patient with suspected narcolepsy type 2?

1 Answer available

What is the upper limit of blood glucose target in hyperglycemic critically ill patients?

The new SCCM guidelines suggest an upper limit of 200 compared to the conventional 180.

1 Answer available

How do you identify which patients are at highest risk for decompensation and most likely to benefit from NIV for pre-oxygenation prior to intubation?

2 Answers available

Does the experience level of the intubation operator affect outcomes related to pre-oxygenation with NIV versus an oxygen mask?

2 Answers available

Does the use of NIV for pre-oxygenation delay the time to intubation?

2 Answers available

Do you administer immunosuppression to patients with idiopathic NSIP who have normal lung function and mild to moderate respiratory symptoms?

1 Answer available

What are your top takeaways from CHEST 2024?

1 Answer available

What factors do you consider for patients on an individual basis when establishing a post-cardiac arrest MAP goal after ROSC is achieved, considering some may benefit from higher MAP goals for optimal cerebral perfusion?

1 Answer available

In cases of intermediate-risk pulmonary embolism, what factors influence your decision to pursue catheter-directed thrombolysis?

1 Answer available

Do you feel high dose Symbicort or Dulera is appropriate to use for SMART despite these doses not being studied in clinical trials?

1 Answer available

How do you approach the bronchoscopic evaluation of a cavitary lesion of the lung?

Do you routinely perform transbronchial biopsies in addition to BAL in all cases?

1 Answer available

What postural change in FVC is suggestive of respiratory muscle weakness?

2 Answers available

How do you manage patients with central sleep apnea due to heart failure with reduced ejection fraction?

Are there specific scenarios in which you employ BPAP with a back up rate?

1 Answer available

What is the minimum daily duration of supplemental oxygen therapy you recommend to patients with chronic hypoxic respiratory failure?

Do findings from the REDOX Trial comparing 24 vs 15 hours of supplemental oxygen influence your approach?

1 Answer available

How do you approach a patient with sarcoidosis who cannot tolerate steroids and who is developing ILD?

Do you use TNF-i or MMF?

1 Answer available

How do you read a PFT with restrictive type spirometry but normal lung volumes?

What clinical significance does this have and how do you follow these patients?

2 Answers available

Do you monitor CBCs to assess for drug toxicity in patients on nintedanib?

1 Answer available

What blood pressure targets do you enforce in the first 24-48 hours in a patient who develops an intracranial hemorrhage after mechanical thrombectomy?

Blood pressure targets for ischemic stroke and intracerebral hemorrhage are described in several guidelines. However, in patients with acute stroke wh...

2 Answers available

What recommendations do you have regarding the use of dronabinol to prevent cannabis withdrawal in an inpatient medical or psychiatric setting?

1 Answer available

Would you treat a sputum culture positive for Aspergillus niger despite an atypical CT chest and a negative serum galactomannan in an immunosuppressed patient who is too high risk for bronchoscopy?

0 Answers available

How do you approach management of ILD in the presence of weakly positive RF and ANA but no other objective systemic findings of connective tissue disease?

Is this managed as CTD-ILD with immunosuppressive +/- anti-fibrotic agents?

1 Answer available

In a patient with low titer +anti-SAE antibody and known ILD, but no other clinical features of dermatomyositis, how would you approach further testing or would you treat the patient as dermatomyositis associated ILD?

1 Answer available

What are the logistical challenges and time constraints of implementing NIV for pre-oxygenation in emergency settings compared to oxygen masks?

1 Answer available

Would bag-mask ventilation with a PEEP valve be a reasonable alternative to NIV for pre-oxygenation prior to intubation in settings where NIV is not easily accessible?

1 Answer available

Is there a subset of patients in whom pre-oxygenation with NRB or BVM could be safely pursued?

1 Answer available

Do you perform EBUS-TBNA for staging in patients with biopsy proven malignant lung nodules with no lymphadenopathy on CT chest and PET scan?

Al-Ibraheem et al., PMID 33731050

3 Answers available

Do you consider surgical thrombectomy in patients with a large, obstructive pulmonary venous thrombosis after lung transplant?

1 Answer available

When would you recommend prescribing an asthmatic patient budesonide/salbutamol rather than budesonide/formoterol?

2 Answers available

How do you approach a patient on anti-TNF with positive Quantiferon (previously negative) with negative chest x-ray and no symptoms?

7 Answers available

Would you add abatacept to treat active inflammatory arthritis in a patient with history of RA-ILD who is already taking mycophenolate?

1 Answer available

Do you administer calcium to patients with K > 6.5 without EKG changes?

3 Answers available

What is the current recommendation for air travel after a primary spontaneous pneumothorax?

2 Answers available

When attempting PEEP titration, how long do you wait after decrements or increments to assess for a change in driving pressure?

2 Answers available

Do you routinely perform echocardiography in patients with Staphylococcus aureus bacteremia deemed low risk for metastatic infection, or do you selectively omit it based on specific clinical criteria?

Hendriks, et al., PMID 38576380

2 Answers available

How do you counsel and manage patients who meet criteria for sleep apnea based on 3% but not 4% desaturation?

2 Answers available

What criteria do you use to determine when to start a steroid-sparing agent for hypersensitivity pneumonitis?

1 Answer available

How would you manage a patient with ANCA associated vasculitis who has recurrent flare including pulmonary hemorrhage, persistent MPO antibody positivity while on maintenance rituximab and avacopan regimen even after induction rituximab therapy?

1 Answer available

What are first-line choices for vasopressors/inotropes to use in hypotensive patients with Eisenmenger Syndrome?

1 Answer available

Do you start immunosuppression for enlarging pulmonary nodules without symptoms, impaired pulmonary function, or extra-pulmonary disease in a patient with sarcoidosis?

1 Answer available

Do you obtain a MSLT or start empiric therapy with modafinil in patients with residual excessive daytime sleepiness despite optimal adherence to PAP therapy?

In patients with average of less than 5 respiratory events per hour, adequate sleep duration and hygiene confirmed on sleep log, absent cataplexy and ...

4 Answers available

How do you workup patients with neuropathy suspected to be secondary to sarcoid?

Is a biopsy or EMG helpful in confirming the etiology? What is the best treatment for sarcoid neuropathy?

1 Answer available

How would you approach treatment of latent TB for patients who cannot tolerate rifamycins or isoniazid due to allergy, intolerance, or drug-drug interactions?

2 Answers available

What would be your recommendation for treatment of worsening lung disease in a patient with long-standing scleroderma after long-term mycophenolate therapy which is no longer an option due to side effect/intolerance?

3 Answers available

Have you noticed poor response to Tyvaso DPI compared to the nebulized form in PH-ILD?

Could the intrinsic inspiratory capacity and distribution of medication be different between the two routes?

1 Answer available

What is your approach to de-escalation of asthma therapy if patients have remained clinically stable on triple inhaler therapy and a biologic agent?

1 Answer available

How do you determine the severity of restrictive lung disease?

1 Answer available

How do you approach determining appropriateness for extubation in a patient with acute respiratory failure in the setting of known chronic neuromuscular disease?

1 Answer available

Do you hold anticoagulation prior to performing bronchoalveolar lavage?

1 Answer available

Do you use absolute random cortisol levels or delta cortisol levels after ACTH stimulation to diagnose adrenal insufficiency in the critically ill?

2 Answers available

Do you preferentially avoid use of piperacillin-tazobactam for empiric anti-pseudomonal coverage in hospitalized patients due to risk of nephrotoxicity?

ACORN Randomized Clinical Trial

1 Answer available

Would you consider adding or switching to pirfenidone for a patient with progressing UIP (based on imaging and PFTs) who is currently on nintedanib?

3 Answers available

Do you ever start a ketogenic diet in patients who present with status epilepticus admitted to the ICU?

1 Answer available

Is there a role for nocturnal supplemental oxygen as opposed to no therapy in patients with OSA who are unable to tolerate PAP therapy?

1 Answer available

How would you manage a patient with morbid obesity who presents with new symptomatic pulmonary embolism a few days after he was started on DOAC for DVT?

What is your preferred anticoagulation in patients with BMI >50?

5 Answers available

Do you start PAP in patients who have an overall AHI of less than 5 but demonstrate significant apneas/hypopneas in REM sleep?

3 Answers available

Is methacholine challenge on its way out?

1 Answer available

Is there a role for the use of transient elastography (FibroScan) to monitor liver fibrosis in patients on long term methotrexate?

3 Answers available

Is there a role for biologics to improve lung function in patients who have severe asthma with daily symptoms and reduced lung function but do not experience frequent exacerbations?

2 Answers available

How would you approach the workup and management of isolated inflammatory subglottic stenosis in a young previously healthy patient that is steroid responsive with a completely negative serologic autoimmune workup?

Would you push for biopsy before deciding on treatment?

1 Answer available

In which cases would you consider early transition to DOAC (within 72 hours) for hospitalized patients with intermediate or high risk PE?

Assume thrombolytics are not indicated. Do you favor early DOAC transition after 24-48 hours of heparin gtt or do you favor LMWH for 10-14 days follow...

2 Answers available

How do you approach management of new onset ILD in a patient with RA who is otherwise well controlled on methotrexate or leflunomide?

1 Answer available

How would you manage cardiac sarcoid with intolerance/contraindications to methotrexate, azathioprine, and mycophenolate/mycophenolic acid and that has proven refractory to adalimumab and infliximab as determined by PET?

2 Answers available

Would you initiate antifibrotic therapy in a patient with CTD-ILD experiencing worsening symptoms and declining lung function, despite no clear evidence of fibrosis on CT scans?

CT changes are subsolid and ground glass nodules.

1 Answer available

Is Metformin contraindicated in patients using long term oxygen therapy at home?

Liang et al., PMID 35900801

1 Answer available

What policies do you take regarding legalized recreational marijuana or medical marijuana use in transplant patients?

1 Answer available

How do you adjust your management strategy to address the unique needs of anuric end-stage kidney disease patients when treating diabetic ketoacidosis?

1 Answer available

How do you approach medication management in biopsy-proven pulmonary sarcoidosis with disease stable for over 2 years on hydroxychloroquine and low dose prednisone?

Do you discontinue HCQ?

2 Answers available

What is your approach to radiographically suspicious lung nodules for which initial biopsy was negative for malignancy?

4 Answers available

Do you give additional pneumococcal vaccines after a dose of PCV20 in patients with asplenia?

1 Answer available

In a patient with acute stroke/ICH/SDH/hyperammonemia at risk for rebound edema with new onset renal failure, do you prefer CRRT versus low and slow HD? How frequently do you monitor osmolarity?

1 Answer available

Do you utilize phrenic nerve EMG in patients with diaphragmatic issues?

2 Answers available

How do you approach the treatment of indeterminate UIP on HRCT with grossly positive MPO antibody and no other features consistent with AAV?

1 Answer available

Can transudative pleural effusions lead to trapped lung?

In trapped lung, a fibrous peel over the visceral pleura restricts pleural expansion. Could transudative pleural effusions lead to this condition?

1 Answer available

Will you incorporate the use of tirzepatide in the management of patients with OSA?

The recently published SURMOUNT-OSA trial showed positive results

1 Answer available

In drawing blood cultures from a central line to evaluate for CLABSI, do you advise drawing separate blood cultures from each port in case of dual or triple lumen line?

If yes, what is the rationale for doing that?

3 Answers available

What is your approach to tapering therapy in patients with pulmonary sarcoidosis who are asymptomatic with stable pulmonary function and imaging?

1 Answer available

Do you continue to prone patients with severe ARDS after initiation of VV-ECMO?

1 Answer available

Can intra-abdominal pressure serve as a surrogate for pleural pressure to titrate PEEP in obese patients or those with intra-abdominal hypertension?

1 Answer available

Is the adage “If GCS <8, intubate” still relevant for non-TBI patients?

Do the findings of the NICO trial influence your stance?

2 Answers available

Do you consider administration of nintedanib or pirfenidone via enteral tube in patients unable to take PO due to recurrent aspiration?

1 Answer available

Would a metal endobronchial stent within the treatment field change your radiation treatment plan for a thoracic malignancy?

1 Answer available

What is your approach to counseling and management of patients with severe symptomatic OSA whose PAP devices have been recalled?

1 Answer available

How does the presence of interstitial lung disease affect your decision to offer SBRT for early stage NSCLC?

Specifically in O2-dependent patients? Have any dose/fractionation regimens been shown to reduce the risk of pneumonitis in this population?

6 Answers available

When do you consider ketamine to treat nonconvulsive status epilepticus?

1 Answer available

Do you favor aggressive airway clearance regimens or bronchoscopy for clearing occluding mucous plugs in patients who are not in respiratory distress?

1 Answer available

Have you used Karius to aid in the diagnosis of a non-resolving pneumonia, with negative bronchoscopy, biopsy, and other infectious work up in an immunocompetent patient?

1 Answer available

Is there still a role for direct laryngoscopy in the intubation of patients in the ICU?

Multiple recent trials have shown higher first pass success rate with VL over DL.

1 Answer available

Have you incorporated the use of linezolid in lieu of vancomycin plus clindamycin for empiric treatment of necrotizing fasciitis?

1 Answer available

Do you administer prophylactic antibiotics to prevent VAP following intubation in patients with acute brain injury?

Do the findings of the PROPHY-VAP trial influence your approach?

2 Answers available

Is there increased risk with lung SBRT in a patient who has a mild asymptomatic pneumothorax in the field after CT-guided needle biopsy?

2 Answers available

When do you consider the use of steroids in the management of acute exacerbations in patients with cystic fibrosis?

3 Answers available

Do you always comment on VA and KCO when reading PFT's when gas transfer is ordered?

1 Answer available

Do you choose an antibiotic with CSF penetration, such as nafcillin over cefazolin, in the setting of MSSA endocarditis with septic emboli to the brain (assuming no concomitant meningitis or brain abscess)?

3 Answers available

Do you consider use of convalescent plasma early in disease course in COVID-19 induced ARDS in mechanically ventilated patients?

Do the results of the recent study (Misset et al., PMID 37889107) showing reduction in 28-day mortality in patients with high neutralizing antibody ti...

1 Answer available

Do you favor the use of maximal inspiratory/expiratory pressure measurement or supine spirometry in the evaluation of a patient with suspected respiratory muscle weakness?

1 Answer available

How do you factor smoking history into biologic selection for asthma since the clinical trials generally excluded these patients?

1 Answer available

Do you recommend careful correction of serum sodium to avoid osmotic demyelination syndrome in patients who are found to have isoosmolar hyponatremia in the setting of an elevated BUN level?

2 Answers available

How do you decide between neoadjuvant or perioperative chemoimmunotherapy, as per Checkmate 816 or KEYNOTE-671, for early-stage NSCLC?

2 Answers available

Do you adhere to the standard 5-day minimum treatment duration for community-acquired pneumonia, or have you used shorter courses for certain low-risk patients?

1 Answer available

What is your approach to withdrawal of ventilatory support at the end of life?

Do you favor gradual reduction in oxygen and pressure support with intermittent medication as needed or immediate extubation with peri-extubation medi...

1 Answer available

What is your approach to management of pulmonary fibrosis in patients with a history of microscopic polyangiitis who do not have other active organ involvement?

Patient is with past history of glomerulonephritis in remission after rituximab for the past 2 years. +MPO/P-ANCA

1 Answer available

What factors do you consider prior to offering a trial of ICS/LABA therapy versus a methacholine challenge test in patients with suspected asthma but normal pulmonary function testing?

1 Answer available

What is the expected timeframe one would expect to see paroxysmal sympathetic hyperactivity/sympathetic storming persist post-traumatic brain injury?

For example, in the setting of TBI, how do you guide the duration of the medical treatment?

2 Answers available

What is your approach to treatment of patients with fulminant C difficile infection who required ileostomy creation or colectomy?

Is there a role for oral vancomycin in these patients, or is oral vancomycin redundant if other routes of administration are being used (i.e intracolo...

1 Answer available

Is there a risk of hepatitis C activation with rituximab in a patient who has a history of HCV treated with antivirals and who is in sustained viral response?

1 Answer available

How do you prescribe a steroid taper for radiation and checkpoint inhibitor related pneumonitis?

I've seen a handful of fatal radiation pneumonitis associated with rapid steroid tapers by the non-treating physicians. How do you recommend prescribi...

2 Answers available

What dose and duration of steroid therapy do you employ while starting mycophenolate in an outpatient with relatively stable CTD-ILD?

Do you ever start mycophenolate without steroids?

1 Answer available

How would you approach a pulmonary-renal PR3+ ANCA vasculitis patient who has persistent re-narrowing of mainstem bronchus after several dilatation and stenting procedures, with other anca features well-controlled on rituximab & avacopan?

5 Answers available

Do you recommend automatically starting CRRT anticoagulation when initiating CRRT if there are no medical contraindications to anticoagulation?

1 Answer available

Do you assess telomere length in all patients with IPF prior to lung transplant?

1 Answer available

Do you perform routine interval lung cancer screening in non-smokers who are 1st degree relatives of patients with non-smoking related lung cancers with known EGFR mutations?

3 Answers available

What is your approach to counseling patients regarding re-initiation of anti-TNF therapy after completion of treatment for non-disseminated pulmonary histoplasmosis?

Would it be safe to resume and if so, when?

2 Answers available

Would you consider deferring chest tube placement in a clinically stable patient with a small empyema without signs of systemic infection?

2 Answers available

Is a larger bore percutaneous chest tube sufficient to adequately drain a hemothorax, or is a surgical chest tube required?

1 Answer available

Is there a subset of ANCA vasculitis patients for which you would try plasma exchange?

2 Answers available

For how long do you recommend treatment for latent tuberculosis prior to initiation of anti-TNF therapy?

6 Answers available

What is your approach to the evaluation and management of a suspected intrapulmonary hematoma?

1 Answer available

What agents do you utilize for mucociliary clearance during the index hospitalization of patients post lung transplant?

1 Answer available

What serologic biomarkers do you send to assess for sarcoidosis at baseline and/or during flares, in patients where it may correlate with disease activity?

Specifically, do you check for any of these: ACE, Vitamin D 1,25, serum lysozyme, soluble IL2 or Adenosine deaminase levels?

1 Answer available

Do you use intrapleural tPA/dornase in loculated effusions that are not due to infection?

1 Answer available

How do you assess the use of Heimlich valves for patients who present with persistent air leaks?

1 Answer available

How do you approach management of adult patients with CVID and sarcoid-like syndrome?

1 Answer available

Are there patients with granulomatosis with polyangiitis on maintenance rituximab therapy for whom you do not co-administer glucocorticoid therapy?

1 Answer available

Do you routinely perform genetic testing in patients presenting with pulmonary fibrosis who endorse a family history of fibrotic lung disease?

1 Answer available

Would you stop azathioprine in a patient with ANCA vasculitis who has been in long term remission on azathioprine, but has a new diagnosis of lung cancer requiring initiation of immunotherapy?

2 Answers available

What are your top takeaways from ISHLT 2024?

1 Answer available

Do you ever consider close clinical monitoring over antifibrotic therapy in patients ascribed an MDD diagnosis of IPF who have normal lung function and are asymptomatic?

2 Answers available

Has your management of severe hyponatremia changed after a recent observational study described higher in-hospital mortality for sodium correction of <6 mEq/L compared to 6-10 mEq/L in the first 24 hours?

Seethapathy et al., NEJM

5 Answers available

How do you manage concurrent nonlife-threatening hemoptysis and acute pulmonary embolism?

Estimating blood loss from hemoptysis is not always reliable. The bleeding may be due to the PE itself. Is anticoagulation with any degree of hemoptys...

1 Answer available

Do you extend the duration of maintenance therapy past 24 months for patients with ANCA glomerulonephritis who have multiple organ involvement?

2 Answers available

For patients with suspected complement-mediated TMA, are there specific clinical or laboratory parameters that can help guide the decision for starting empirical treatment (e.g., eculizumab) while awaiting the results of complement testing?

1 Answer available

Do you utilize robotic bronchoscopy to biopsy a lung cavity wall?

1 Answer available

How do you manage diarrhea in a patient with CTD-ILD on MMF who was recently started on full dose nintedanib?

5 Answers available

Have you incorporated the use of steroids for patients with severe community-acquired pneumonia?

In light of published data from the CAPE COD trial...

1 Answer available

Is there a role for repeat surveillance blood cultures in patients with prosthetic valve endocarditis without associated cardiac abscess after a 6 week course of antibiotic treatment without surgical intervention?

1 Answer available

Do you diagnose obstruction by the criteria of FEV1/FVC < 70% or < LLN?

5 Answers available

When do you consider the use of PH specific therapies in patients with pre-capillary pulmonary hypertension associated with sickle cell disease?

2 Answers available

Do you treat A0B1 rejection noted on surveillance bronchoscopy in a patient less than one year post lung transplant?

1 Answer available

Is there a role for chronic suppressive oral or inhaled therapy for recurrent Burkholderia cepacia pneumonia causing frequent hospitalizations in a patient with severe bronchiectasis with or without underlying cystic fibrosis?

3 Answers available

Does your institution have formal policies or work flows to reduce unnecessary IGRAs ordered for patients on biologics?

1 Answer available

Do you use acetazolamide to aid diuresis in patients with acute on chronic respiratory acidosis with significantly elevated serum bicarbonate levels?

3 Answers available

In what clinical scenarios do you utilize post-cardiac arrest targeted temperature management (TTM)?

In the span between the HACA trial and the Targeted Temperature Management in Out-of-Hospital Cardiac Arrest study (Dankiewicz et al., PMID 34133859),...

1 Answer available

Do you use hypercapnia as an exclusion criteria in all patients that are being assessed for bronchoscopic lung volume reduction?

1 Answer available

How do you follow pulmonary embolism patients who have completed anticoagulation?

1 Answer available

Is there a role for nintedanib in the management of patients with radiation-induced pulmonary fibrosis?

1 Answer available

Do you use any drugs prophylactically to reduce the risk of radiation pneumonitis in lung SBRT?

Would you provide pentoxyphylline and vitamin E prophylactically after treatment? Is there a role for Boswellia? ACE inhibitor?

1 Answer available

Do you routinely use 3% sodium chloride and desmopressin to correct hypovolemic hyponatremia in an asymptomatic patient with serum sodium of less than 120 mEq/L?

3 Answers available

In which patients do you prefer daily standard three-drug therapy for non-cavitary pulmonary MAC as opposed to three times a week dosing?

2 Answers available

What protective post-op measures do you recommend for a patient with scleroderma and a history of ILD, PH, Raynaud’s and digital ischemia undergoing cardiothoracic surgery?

1 Answer available

In patients being evaluated for brain death, which abnormal movements are definitively known to still be consistent with brain death and which are possibly consistent with brain death but lack definitive evidence?

What are the sources for this and are they reliable by today’s standards? Numerous case series report various abnormal movements but how reliabl...

1 Answer available

How are you navigating approval of CPAP for patients with a high suspicion for OSA on chronic oxygen who are unable to complete an in-lab PSG?

2 Answers available

How do you navigate PAP approval for patients with tracheobronchomalacia or excessive dynamic airway collapse who do not have OSA?

1 Answer available

Do you consider skin involvement associated with tattoos to be a marker of disease activity and an indication to start treatment in a patient with sarcoidosis?

1 Answer available

What is your approach to the use of acetazolamide in patients with OSA?

1 Answer available

Would you start any treatment for radiation pneumonitis if there is a large area of consolidation in the irradiated lung field but the patient is asymptomatic?

Would you consider pentoxifylline and vitamin E to mitigate fibrosis?

2 Answers available

Should checking a urinalysis with reflex to culture be part of the standard work up for fever in an ICU patient with a urinary catheter?

2 Answers available

Do you obtain an echocardiogram as a part of risk stratification in all patients hospitalized with an acute pulmonary embolism?

2 Answers available

How do you approach biologic initiation in patients with inflammatory arthritis and repeatedly indeterminate Quantiferon?

5 Answers available

How do you approach patients with RA and severe bronchiectasis with associated findings of UIP?

1 Answer available

How do you determine if pulmonary hypertension is disproportionate to the severity of lung disease?

2 Answers available

How do you approach treating and monitoring sarcoidosis manifested by maxillary bone/teeth loss without other symptoms?

3 Answers available

When do you pursue interventional treatments in a lung transplant patient with anastomotic dehiscence complicated by a bronchopleural fistula?

1 Answer available

What else do you consider in the differential diagnosis for pulmonary-renal syndromes if there is low clinical and serologic evidence of AAV, Goodpasture's or other rheumatologic disease (SLE, RA, APS, Scleroderma)?

2 Answers available

What is your approach to the management of persistent hydropneumothorax due to a non expandable lung?

1 Answer available

What patient factors, if any, would lead you to extubate a patient at high risk of extubation failure to AVAPS rather than BIPAP?

1 Answer available

How do you define severe hypoxic burden on home sleep testing?

1 Answer available

What factors do you consider while selecting high risk patients for prophylactic NIV after planned extubation?

1 Answer available

What is your approach to inhaler therapy in a patient with asthma who cannot be on an inhaled corticosteroid due to ocular disease?

1 Answer available

In light of the RECITAL study, would rituximab be a reasonable choice in a patient with PL-12 antibodies, rapidly progressive pulmonary disease with organizing pneumonia on biopsy?

Given poor pulmonary outcomes in people with anti-PL12 antibodies, would you recommend more aggressive therapy? The patient was diagnosed with onset o...

1 Answer available

How are you approaching patients with early-stage NSCLC who progress on neoadjuvant chemo-immunotherapy and are no longer surgical candidates?

5 Answers available

What is your preferred mechanism for venting the left ventricle in patients on VA-ECMO?

2 Answers available

Would you restart sirolimus for a decline in lung function or pneumothoraces in a pregnant patient with LAM?

1 Answer available

How do you risk stratify patients with different WHO groups of pulmonary hypertension prior to non-cardiac surgeries?

And who would you not recommend to undergo surgeries?

1 Answer available

What would be your second pressor of choice if patients with LVOT obstruction remain persistently hypotensive on phenylephrine?

1 Answer available

Are SCDs contraindicated in patients with acute DVTs?

Is it different than early mobility that we always encourage?

3 Answers available

How would you manage asymptomatic osseous sarcoidosis of the lumbar spine without any other systemic involvement?

Would you use with DMARDs/biologics or monitor?

1 Answer available

Do you use FVIII levels to differentiate between DIC and coagulopathy of liver disease?

Common thought is that FVIII may be used for differentiating coagulopathy in liver disease (normal to increased, from reduced clearance of VWF/FVIII) ...

4 Answers available

Is there an age at which you consider not starting antifibrotic therapy in a patient with IPF?

1 Answer available

Do you perform PEEP titration while patients are proned?

1 Answer available

What is your approach for disease activity monitoring in patients with sarcoidosis?

1 Answer available

Do you consider immunosuppressive agents in progressive interstitial pneumonias or pneumonitis without a clear driving etiology?

1 Answer available

Do you add fludrocortisone to hydrocortisone when starting stress dose steroids in a patient with septic shock?

Though there is data to support using both hydrocortisone and fludrocortisone, it seems to be used rarely in clinical practice. A review publishe...

1 Answer available

Do you consider pulmonary hypertension related to sarcoidosis to be an indication to start steroids?

Do you use biomarkers or PET scanning to stratify patients who may benefit most from therapy?

1 Answer available

How would you approach medication de-escalation in a patient with a history of rapidly progressive CTD-ILD who responded to and is currently on mycophenolate 3 grams daily and IVIG 2mg/kg monthly infusions and has been stable for two years?

2 Answers available

Does your approach to extubating obese patients differ from your approach in non-obese patients?

1 Answer available

How do you approach management of a patient with Sjogren's disease and lung mass biopsy revealing amyloidosis?

1 Answer available

Do you routinely use vasopressin in the management of RV failure leading to shock state in the absence of an obvious treatable cause such as infarction or PE?

2 Answers available

How do you approach management of a patient with idiopathic PAH and +ANA, but no other current symptoms/signs of active rheumatologic disease?

3 Answers available

Is there a role for monitoring serum ANCAs to assess ANCA associated vasculitis disease activity?

This question is part of a collaboration with RheumMadness and is in reference to Pathogenic ANCA (RAVE Trial).

2 Answers available

Is it safe to combine mycophenolate and adalimumab for management of pulmonary sarcoidosis in a patient that could not tolerate methotrexate?

3 Answers available

When should SBRT be preferred in operative patients who cannot undergo a lobectomy?

In other words, if offered wedge or segmentectomy, should SBRT be preferred? Does size matter ie if the lesion is < 3 vs < 2 vs < 1 cm? Does ...

2 Answers available

What is your approach to the management of symptomatic Cystic Fibrosis carriers?

1 Answer available

How long post operatively do you wait before transitioning from parenteral anticoagulation to oral anticoagulants after pulmonary thromboendarterectomy for CTEPH?

2 Answers available

What is your approach to monitoring patients with cardiac sarcoid while tapering immunosuppression?

Do you obtain serial cardiac PET scans?

1 Answer available

What is your preferred strategy for controlling bleeding after transbronchial or endobronchial biopsies?

1 Answer available

How do you manage immunosuppressive medications in patients who develop a pneumonia?

1 Answer available

What therapies do you routinely use to prevent mucus plug formation after endobronchial stent placement?

1 Answer available

What is your threshold to start triple therapy in mild to moderate asthma/COPD overlap with minimal functional limitation?

1 Answer available

Is dyspnea without radiation pneumonitis a side effect of lung radiation?

Is this acute or long-term, and does it matter whether this is SBRT vs fractionated?

4 Answers available

Do you prefer using end-expiratory or mean pulmonary artery wedge pressure obtained during diagnostic right heart catheterization for the classification of precapillary vs postcapillary PH?

1 Answer available

What is your approach to steroid sparing therapy in patients with suspected CTD-ILD?

2 Answers available

How long do you normally wait before considering any bronchoscopic procedure (EBUS-TBNA, Transbronchial biopsy) after an episode of acute PE in a patient needing these procedures?

Normally, waiting 6-12 weeks of therapeutic anticoagulation after an acute PE is suggested for any bronchoscopic procedure, however there is always a ...

1 Answer available

What are your top takeaways from CHEST 2023?

2 Answers available

What are best practices in management of severe acute infusion reaction from infliximab?

Patient became acutely flushed, developed severe and prolonged hypotension with brief loss of consciousness, dizziness, nausea, dry heaves and headach...

1 Answer available

What is your approach to a patient who has a cardiac PET scan suggestive of sarcoid but no other supporting evidence of a diagnosis of sarcoid?

Do you typically push for myocardial biopsy in this case?

1 Answer available

What patient factors prompt you to consider starting dupilumab in patients with COPD?

Does active smoking status influence this decision?

2 Answers available

Did the low rate of COPD exacerbations in the BOREAS cohort overall confound the results of the study?

2 Answers available

Are the results of the BOREAS trial generalizable to non-white populations?

The cohort in the study was predominantly white. Do these results highlight significant disparities in COPD care?

2 Answers available

Will you use FeNO testing in all COPD patients to determine whether they are candidates for therapy with dupilumab?

If so, would this be a consideration in all patients regardless of active smoking status? FeNO in active smokers has been questioned, could this have ...

2 Answers available

Would you give T-DXd to patients with resolved drug-induced ILD from other agents such as prior chemo/targeted therapy/immunotherapy?

2 Answers available

What is your approach in differentiating IPAF (interstitial pneumonia with autoimmune features) versus "CTD ILD" in patients with serologic abnormalities but do not fulfill criteria for autoimmune disease?

1 Answer available

How long do you continue surveillance with imaging and sputum cultures in a patient with NTM with no indications for treatment?

3 Answers available

Have you seen rheumatoid nodules or RA-ILD in patients with seronegative RA?

While classically described as seen in seropositive patients, have they been reported in seronegative RA?

2 Answers available

What is the risk of ILD recurrence in MDA5/Ro52 positive dermatomyositis following a lung transplantation?

2 Answers available

When do you entertain a diagnosis of HLA-negative antibody mediated rejection in lung transplant recipients?

1 Answer available

How would you manage a patient with radiation pneumonitis who remains symptomatic on steroids?

2 Answers available

When do you consider the use of corticosteroids in patients diagnosed with EVALI?

1 Answer available

What is your approach to volume resuscitation in patients with obvious septic shock but also with a component of suspected cardiogenic shock?

4 Answers available

Do you increase sedation or consider the use of neuromuscular blockade to prevent potential self-induced lung injury in patients with high respiratory drive?

2 Answers available

What is your approach to initial work up for a young patient with bronchiectasis?

2 Answers available

Do you ever initiate pirfenidone in patients with CTD-ILD?

1 Answer available

Do you prescribe bronchodilators to patients with radiographic emphysema and respiratory symptoms, but no spirometric obstruction?

1 Answer available

Are there preferred home exercise programs for patients without access to pulmonary rehabilitation?

1 Answer available

What is your initial treatment of choice in patients with RA and associated interstitial lung disease?

1 Answer available

Do you attempt more aggressive PEEP titration to improve the P/F ratio prior to proceeding with proning in patients with ARDS and P/F <150?

1 Answer available

Do you discontinue proning due to a perceived lack of response to intervention in a patient with ARDS?

2 Answers available

What is your approach to the management of a patient with idiopathic pneumonia syndrome following stem cell transplant who does not demonstrate clinical improvement with steroid therapy?

1 Answer available

How do you manage GI side effects related to CFTR modulator therapy?

2 Answers available

Is there a role for biologics to help patients with ABPA who are steroid responsive and have removed their allergen insult, but continue to have an elevated serum IgE and incomplete resolution of symptoms return to their baseline functional status?

1 Answer available

Do you consider dual biologic therapy in patients with ABPA that remain steroid dependent despite the use of omalizumab?

2 Answers available

How do you approach the use of chronic azithromycin in patients with CF who may require therapy with IV tobramycin in the future?

Given the suggestion of the antagonistic effect of azithromycin on IV tobramycin in prior studies.

1 Answer available

When do you screen for pulmonary hypertension in ILD patients?

1 Answer available

What strategies do you employ to prevent post-intubation hypotension in a profoundly hypoxic patient given a paralytic for intubation?

1 Answer available

What strategies do you employ to minimize the risk of cardiovascular collapse when intubating a patient with severe pulmonary hypertension?

Do you favor awake intubation in these cases?

2 Answers available

Do you recommend transfer to an institution with a PE response team for a patient with an intermediate risk PE?

1 Answer available

Is there a role for the use of biologics as steroid sparing agents in treating patients with ABPA who are intolerant to prednisone?

1 Answer available

What is your approach to using nintedanib in patients on baseline immunosuppression?

Patients on baseline mycophenolate and azathioprine were excluded from the INBUILD trial however many patients with CTD-ILD will be on some form of im...

5 Answers available

What is your preferred steroid sparing agent in the treatment of Sjögren associated LIP?

2 Answers available

What is your approach towards management of symptomatic broncholithiasis?

What factors do you consider while deciding between bronchoscopic vs surgical management?

1 Answer available

Do you use continuous or intermittent bronchodilator therapy in severe airway obstruction?

1 Answer available

Would you place an IVC filter in a patient with an acute intermediate risk PE and a proximal DVT who is on anticoagulation?

1 Answer available

Is there any utility in using lytics for loculated malignant pleural effusion?

1 Answer available

Would you consider the use of dual antifibrotic therapy (nintedanib and pirfenidone together) for progressive fibrosing ILD?

4 Answers available

Does your approach to treating latent tuberculosis differ in a patient on anti-fibrotic therapy?

1 Answer available

Do you routinely start full dose anticoagulation in new onset atrial fibrillation in the ICU?

2 Answers available

Do you rule out TB in patients with AIDS and lobar pneumonia?

What’s your threshold to get the three AFBs and place the patient in airborne isolation?

1 Answer available

Do you routinely monitor imaging or pulmonary function in patients with pulmonary TB after the completion of therapy?

1 Answer available

Do you transfuse platelets prior to central line placement in patients with platelet counts less than 50,000?

1 Answer available

What is your approach to PEEP titration in the management of a morbidly obese patient with ARDS?

1 Answer available

Do you routinely use inhaled pulmonary vasodilators in the management of patients with ARDS with refractory hypoxemia?

1 Answer available

Do you use sitting vs supine spirometry to consider tracheostomy in a patient with Amyotrophic Lateral Sclerosis?

1 Answer available

What is your second line therapy for patients with EGPA with mainly pulmonary and sinonasal features who did not respond to mepolizumab 300 mg/month and still require high doses of steroid?

2 Answers available

Which hemodynamic parameters can be used to titrate positive pressure ventilation in preload dependent settings such as RV failure, cardiac tamponade, HOCM or hemodynamically significant PE?

2 Answers available

How do you approach treating mild hypercalcemia in patients with sarcoidosis?

1 Answer available

Do you perform spontaneous breathing trials on higher levels of PEEP with extubation to positive pressure ventilation in patients intubated for obesity hypoventilation syndrome?

2 Answers available

Do you routinely use hypertonic saline for pulmonary toileting in patients with non-CF bronchiectasis?

1 Answer available

Is an early chest tube and tPA/Dornase therapy for a loculated and complex pleural effusion that is not an empyema or hemothorax helpful in reducing the rate of developing trapped lung?

1 Answer available

What are your top takeaways from ATS 2023?

2 Answers available

Do you start steroid therapy in a patient with pure ARDS without septic shock, or would you only consider steroids only in those with severe community acquired pneumonia?

To help interpret clinical applications of the CAPE COD (2023) and DEXA ARDS (2020) trials.

2 Answers available

When do you begin antifibrotic therapy for a patient with newly diagnosed ILD that is not IPF?

Do you base the decision on FEV1, 6MWD or symptoms at initial evaluation, or progression over time?

6 Answers available

Do you routinely continue using TPA/Dornase for treatment of empyema, if there is accumulation of new sero-sanguinous output from the chest tube after the initial treatment?

Are there any quantitative indices (eg. volume, pleural fluid hematocrit) that would impact your decision to stop subsequent TPA/dornase treatments?

1 Answer available

What indicators do you use to determine whether a patient is having a favorable or unfavorable response to nintedanib?

When adding nintedanib what sort of treatment course do you counsel the patient on? Do you plan to continue it indefinitely as long as the patient tol...

3 Answers available

Do you generally recommend starting nintedanib prior to immunosuppressive therapy in a patient with CTD-ILD?

Do you prefer to start with nintedanib and then add immunosuppressive agents, or give a trial of immunosuppressive medication first, then add nintedan...

4 Answers available

What is your approach to management of elderly patients with cardiopulmonary comorbidities and severe pulmonary hypertension?

1 Answer available

Do you screen for interstitial lung disease in patients with newly diagnosed polymyositis or dermatomyositis in the absence of respiratory symptoms?

3 Answers available

What is your threshold to start stress dose steroids in the management of patients with septic shock?

Do you do start therapy at a certain vasopressor requirement?

2 Answers available

How do you define an adequate EBUS when staging NSCLC?

Is there a minimum standard for which stations to sample? Does lymph node size affect your recommendations?

3 Answers available

Are you using NAC in lieu of hypertonic saline amidst the current shortage of hypertonic saline in patients with either CF or non-CF bronchiectasis?

1 Answer available

What is your approach to the monitoring and management of a never-smoker with respiratory symptoms and a nonspecific ventilatory pattern on pulmonary function testing?

1 Answer available

What dose and duration of steroid therapy do you use in steroid responsive ILD?

1 Answer available

What is your next step in management for a patient with immunotherapy induced pneumonitis that does not improve on high dose steroids for 48 hours?

How do you decide between starting infliximab, MMF, or IVIG? If a patient presents in respiratory failure (nearing or requiring intubation), woul...

1 Answer available

Do you employ the use of noctournal oximetry to assess for a need for supplemental O2 in addition to auto PAP in patients with OSA who have not had an in lab CPAP titration study?

2 Answers available

Do you continue methotrexate while starting TNFi therapy in patients with refractory pulmonary sarcoidosis?

3 Answers available

How do you choose between azithromycin and roflumilast in the management of a patient with severe COPD who remains symptomatic with frequent exacerbations despite maximal dose LABA/LAMA/ICS with demonstrated compliance and proper inhaler technique?

1 Answer available

How do you approach treatment of septated parapneumonic pleural effusions that do not satisfy traditional criteria for complicated effusion after diagnostic thoracentesis?

Is there any role of tube thoracostomy as opposed to only antibiotics?

1 Answer available

What is the optimal frequency and duration of post-operative radiological surveillance following resection of a solitary fibrous tumor?

1 Answer available

What is your perspective on the role of respiratory therapists in managing a patient who is dyssynchronous on their current mode of mechanical ventilation?

Do your respiratory therapists independently adjust ventilator settings without direct physician involvement?

2 Answers available

Do you offer immunosuppression to patients with CTD-ILD with concomitant well controlled HIV?

2 Answers available

For NSCLC patients with limited diagnostic tissue that is insufficient for genetic testing, do you offer repeat biopsy (of accessible site), blood based testing, or both to evaluate for actionable driver mutations?

3 Answers available

What is the role for "liquid biopsy" for patients with newly diagnosed metastatic NSCLC?

5 Answers available

Are you using the microbial cell-free DNA “Karius” test to aid in the diagnosis of an atypical pulmonary infection such as PJP or NTM?

2 Answers available

Do you use steroids in patients with respiratory failure who are infected with both influenza and COVID-19?

How do you approach which risk to accept given that steroids have evidence for use in COVID-19 while is suggestion for harm in using steroids in influ...

1 Answer available

Do you use prednisone in the management of patients with persistent respiratory symptoms following acute COVID-19 infection?

4 Answers available

How do you manage recurrent inflammatory pleural effusions in lupus pleuritis?

1 Answer available

What is your approach to counseling a patient with exertional hypoxia, but normal resting oxygen saturation, who is hesitant to use supplemental oxygen therapy?

1 Answer available

How do you complete brain death testing in patients who cannot tolerate apnea testing and are unable to transport for ancillary testing?

For instance, if the patient doesn’t tolerate apnea testing, is too unstable to go for ancillary testing outside the ICU, and TCDs/EEG are unava...

5 Answers available

What steroid regimen do you employ prior to extubating a patient who does not have a suitable cuff leak?

2 Answers available

What is your approach to therapy for pulmonary sarcoidosis resistant to methotrexate?

1 Answer available

What steroid regimen do you use in patients with both septic shock and ARDS?

Do you use hydrocortisone 200 mg/day as studied in ADRENAL/APROCCHSS or dexamethasone 20 mg/day as studied in DEXA-ARDS?

2 Answers available

How would you treat a patient with combined pre- and post-capillary pulmonary hypertension after successfully optimizing post-capillary pressures through a valvular intervention?

2 Answers available

Do you consider the duration of lung/lobar atelectasis in your decision making while offering airway stents for malignant central airway obstruction?

Are patients with long standing malignant central airway obstruction poor candidates for central airway stents? What is considered to be an acceptable...

1 Answer available

Is there any role for palliative radiation in patients who are intubated due to malignant airway obstruction?

Given the substantial risks associated with transporting an intubated and ventilated patient to Radiation Oncology, is there any evidence to support t...

5 Answers available

Do you routinely isolate and test for TB in a patient incidentally found to have a miliary pattern of nodules on chest CT?

2 Answers available

What is your approach to pulmonary vasodilator therapy in patients with COPD and Severe Group 3 Pulmonary Hypertension?

1 Answer available

Do you continue CFTR modulator therapy in patients with extra-pulmonary manifestations of CF after lung transplant?

1 Answer available

What are your preferred ventilatory settings/mode(s) for patients with acute hypoxic respiratory failure presenting with severe biventricular dysfunction in cardiogenic shock?

1 Answer available

Does your approach to the management of a patient with an acute exacerbation of CPFE where the ILD is attributed to IPF differ from the management of a patient with an exacerbation of IPF alone?

1 Answer available

Would you restart prophylactic anticoagulation in a patient with a history of unprovoked PE who received short term anticoagulation with a prior physician?

E.g. low dose DOAC

1 Answer available

What is your preferred management for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)?

Does your management change if symptomatic or asymptomatic?

1 Answer available

How would you manage immune check point inhibitor induced capillary leak syndrome refractory to IVIG monotherapy?

1 Answer available

Do you routinely use donor derived cell free DNA levels to guide surveillance bronchoscopies in lung transplant recipients?

2 Answers available

Would you give checkpoint inhibitor therapy to a cancer patient with known dermatomyositis given the association of checkpoint inhibitor associated myocarditis, myasthenia gravis, and myositis?

6 Answers available

Is there a role of everolimus or capecitabine and temozolomide in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia in patients already on octreotide?

1 Answer available

What is your approach to therapy in patients with progressive Scedosporium pulmonary infection who are not candidates for surgical debridement?

1 Answer available

How do you monitor for pulmonary toxicity for patients on trastuzumab deruxtecan?

Would you obtain baseline PFT on all patients or only selected high risk patients? Would you repeat PFTs regularly or only if clinically symptomatic?&...

5 Answers available

Do you routinely use milrinone to augment RV function in patients with massive pulmonary emboli on vasoactive support?

1 Answer available

How do you approach management of limited stage SCLC in a patient with idiopathic pulmonary fibrosis?

3 Answers available

What is your approach to the management of a patient with PAH who is resistant to contraception and planning a pregnancy?

1 Answer available

Are there known biomarkers predictive of IRAEs?

3 Answers available

Do you routinely use sweat tests if you are going to titrate a CF patient onto a lower dose of ETI for any reason (allergy, mental health, etc) to assess the severity of their response to the lower dose?

1 Answer available

Are there any concerns utilizing apremilast for psoriatic arthritis in patients who are also taking roflumilast for COPD?

1 Answer available

Do you prescribe antifibrotics to patients with combined pulmonary fibrosis and emphysema (CPFE)?

1 Answer available

When can abdominal surgery be safely performed for presumptive ovarian cancer in a patient with recent pulmonary emboli?

(Normal oxygenation and echo)

1 Answer available

Is there any PFT criteria that you use in guiding decision making to offer transbronchial lung cryobiopsy to patients with interstitial lung disease?

1 Answer available

What are your top takeaways from CHEST 2022?

2 Answers available

How do you manage steroid-refractory immune checkpoint inhibitor induced pneumonitis?

4 Answers available

Do you treat Candida spp isolated from a bronchoalveolar lavage?

1 Answer available

Is there a role for biologic therapies in asthma-COPD overlap syndrome with evidence of type 2 inflammation?

2 Answers available

What is your approach to the work up and management of interstitial lung abnormalities?

1 Answer available

How do you approach performing EBUS TBNA in patients with latex allergy?

Apart from removing the latex balloon, do you employ any additional technical accommodations?

1 Answer available

Do you routinely continue airway clearance therapies in the setting of mild to moderate hemoptysis in a patient with CF?

2 Answers available

Would you consider prophylactic antifungal treatment prior to immunosuppressive therapies in a patient with previously treated pulmonary coccidiomycosis and residual parenchymal changes?

1 Answer available

Do you often see clinical improvement that is significant enough to de-list patients with CF for transplant after the initiation of CFTR modulator therapy?

2 Answers available

Do you ever stop tobramycin prophylaxis in a patient with chronic bronchiectasis previously colonized with pseudomonas?

2 Answers available

Do you perform a clamp trial before removing a chest tube for pneumothorax?

2 Answers available

Do you do recommend further mediastinal staging for patients with SCLC or inoperable NSCLC with N1 disease on PET?

If a patient clearly has N1 disease with high SUV on PET, do you routinely recommend EBUS or mediastinoscopy to evaluate for N2 disease?

1 Answer available

What is your preferred steroid sparing therapy in a patient experiencing a severe checkpoint inhibitor toxicity and not responding to high dose IV steroids?

2 Answers available

What patient characteristics would lead you to opt for triple therapy versus double therapy in newly diagnosed PAH?

1 Answer available

Do you give intrapleural lytics for complicated effusion/empyema in patients on systemic anticoagulation?

1 Answer available

What steroid regimen do you employ in the treatment of patients with post COVID-19 pulmonary fibrosis?

2 Answers available

Do you ever employ the use of prolonged periods of pressure support ventilation as means of "weaning" in the management of patients with acute respiratory failure?

1 Answer available

How would you manage subclinical ILD associated with MDA-5 Dermatomyositis?

Any indications for triple therapy in the patients with subclinical ILD associated with MDA-5 dermatomyositis?

1 Answer available

Would you consider PLEX for patients with DAH from SLE-associated capillaritis?

1 Answer available

How frequently do you monitor LFTs and CBC after initiating endothelin receptor antagonists?

Is there a difference in monitoring frequency for legacy drugs like bosentan vs newer agents (macitentan, ambrisentan)?

3 Answers available

Do you find that complete interlobar fissures on HRCT correlate well with decreased collateral ventilation on endoscopic balloon occlusion in the evaluation and placement of endobronchial valves for bronchoscopic lung volume reduction?

2 Answers available

Do you favor the use of Fick or thermodiluation to measure cardiac output in patients with interstitial lung disease with suspected pulmonary hypertension?

Occasionally, supplemental oxygen may alter Fick measurements giving falsely high CO and falsely low PVR, therefore is Thermodilution method preferred...

2 Answers available

Which images do you routinely request when ordering a HRCT chest?

1 Answer available

In a patient with history of pneumonectomy would you consider SBRT for treatment of a new tumor in the remaining lung?

1 Answer available

When do you consider Balloon Pulmonary Angioplasty in patients with inoperable CTEPH?

1 Answer available

Do you consider extensive clot burden as a factor in determining whether patients with submassive PE may be appropriate for thrombolytic therapy?

3 Answers available

Do you consider bronchoscopic lung volume reduction in patients with homogenous emphysema?

1 Answer available

Do you consider the use of bevacizumab in patients with HHT who have high output cardiac failure related to liver AVMs who also have cerebral AVMs?

1 Answer available

What workup do you do for patients who have PL-7 elevation when screening for myopathy?

2 Answers available

Do you recommend the use of endobronchial valves in the management of patients with spontaneous pneumothorax with persistent air leak?

1 Answer available

What are your top takeaways in Thoracic Cancers from ASCO 2022?

What were your “top 3” presentations/studies coming out of the meeting this year and how will it impact your own clinical practice?

6 Answers available

Do you recommend the use of indwelling pleural catheters in the management of patients with hepatic hydrothorax requiring frequent drainage?

1 Answer available

What criteria do you use to consider pleurodesis vs indwelling tunneled catheters in patients with malignant pleural effusion?

1 Answer available

How do you counsel patients regarding prognosis following a diagnosis of IPF?

1 Answer available

How do you approach a thoracic lymph node that is highly suspicious on CT and PET but negative on EBUS in patients with NSCLC?

3 Answers available

Is there a role for immunosuppression in addition to standard PAH therapy in the management of pulmonary hypertension associated with primary Sjogrens syndrome?

Assuming other non CTD related causes for PAH have been excluded

1 Answer available

Do you adjust immunosuppression in lung transplant recipients diagnosed with COVID-19?

2 Answers available

Is there a role for the use of inhaled corticosteroids in patients with pulmonary sarcoidosis who have stage II or III disease with abnormal lung function but only mild respiratory symptoms?

1 Answer available

How do you clinically distinguish between group I and group III PH in patients with CTD-ILD?

1 Answer available

Do you utilize soluble IL-2 receptor or ACE levels as serum biomarkers to monitor disease activity in pulmonary sarcoidosis?

1 Answer available

Based on findings of the INCREASE trial, are you routinely prescribing inhaled treprostinil to patients with group 3 pulmonary hypertension secondary to interstitial lung disease?

1 Answer available

How do you manage a stenotic airway following SBRT or hypofractionated radiation to a central lung tumor?

Are there situations in which you would recommend dilation of stenotic airways after radiation? Is there a concern for increased complications of dila...

1 Answer available

How do you treat patients with sarcoid who have persistent symptoms after an initial 6 week course of corticosteroids?

3 Answers available

Do you consider the use of antifibrotics at presentation in patients with a radiographic UIP pattern of pulmonary fibrosis in the presence of positive serologies without any symptoms of CTD who have not yet demonstrated evidence of a progressive phenotype?

1 Answer available

Do you de-escalate airway clearance therapies in patients with CF who experience an improvement in mucus production and clearance after CFTR modulator therapy is started?

1 Answer available

Do you employ the use of extracorporeal photopheresis in the management of patients with progressive BOS following lung transplantation?

Clinical trial NCT02181257 to explore this currently in process

1 Answer available

Do you employ the use of external chest compression with sandbags in the management of patients with severe ARDS who are not candidates for proning?

1 Answer available

When would you consider biopsy for an incidentally noted, PET negative, solid, solitary pulmonary nodule that is >8mm in size?

1 Answer available

Is there a role for antifibrotic therapy in post COVID-19 pulmonary fibrosis?

1 Answer available

Do you consider EBUS TBNA in the diagnostic evaluation of patients with mediastinal lymphadenopathy with concern for lymphoma?

1 Answer available

What are best practices for engaging with multidisciplinary colleagues to ensure patients with earlier stage NSCLC are being appropriately considered for novel adjuvant therapies?

How are your teams effectively evaluating and counseling patients to ensure they are prepared for potential extended adjuvant treatment approaches? Is...

4 Answers available

What is your approach to treatment for a patient with progressive ILD (UIP pattern) with high titer RF but no articular symptoms?

1 Answer available

Would you advise a patient with quiescent vasculitis who flared with the first Covid mRNA vaccine to obtain an additional dose?

Would you suggest switching to a viral vector vaccine, such as J&J?

2 Answers available

Would you offer adjuvant chemotherapy, osimertinib, or both to a patient with Stage IB EGFR mutated lung adenocarcinoma found in the lung explant pathology after bilateral lung transplant?

Would you consider the immune suppressed status of the patient as a high risk factor to offer adjuvant therapy?

1 Answer available

How do you treat multisystem sarcoidosis refractory to methotrexate, humira, and remicade?

2 Answers available

What strategies can be employed to manage interstitial lung disease seen with trastuzumab deruxtecan?

Can patients be re-challenged after developing ILD? Is the toxicity seen with T-Dxd a potential barrier to use? Do you feel the dosing used in...

2 Answers available

How would you approach treatment for fulminant RA-associated ILD?

Would you discontinue Methotrexate and TNF inhibitors even if previously no side effects from these medications, and would you consider Cyclophosphami...

1 Answer available

What are your recommendations regarding methotrexate usage in patients with persistent chest CT changes post COVID pneumonia?

Would you have a different opinion based on whether it is a new therapy or an existing and previously well-tolerated therapy for the patient?

2 Answers available

How do you evaluate a suspicious, but negative pleural effusion when working up NSCLC and SCLC?

Are two negative pleurocentesis' adequate to conclude that the patient does not have metastatic disease? Do you routinely recommend VATS and pleural b...

1 Answer available

Do you routinely recommend a sleep study in patients with clinical history of REM-sleep behavior disorder?

Does this add any value?

1 Answer available

What criteria do you use on echocardiogram and PFT to determine who needs further evaluation for CTD-associated pulmonary hypertension?

1 Answer available

What indicators do you use to identify patients with CTD-ILD who do not have potential to improve from continued immunosuppressive therapy?

Do you use imaging (fibrosis vs. pneumonitis), PFTs, duration of prior immunosuppressive therapy?

1 Answer available

What is your preferred regimen for remission induction and maintenance in EGPA with cardiac involvement?

1 Answer available

How do you approach patients with ANCA vasculitis who had partial response, but continue to have disease activity on q 6 month maintenance rituximab and remain on steroids?

Would you change rituximab maintenance dose or schedule?

1 Answer available

How do you choose between oral and IV cyclophosphamide for the treatment of ANCA-associated vasculitis?

1 Answer available

What is your approach for a symptomatic inpatient with locally advanced NSCLC who cannot have a PET?

Would you consider treating the full mediastinum or any mildly enlarged nodes, even contralateral? Do you have a strategy that transitions from a pall...

2 Answers available

What immunosuppressive agents aside from steroids would you use to treat bronchiolitis obliterans in a patient with long-standing seropositive RA?

1 Answer available

How do you approach the management of SSc-ILD in a patient on immune checkpoint therapy?

1 Answer available

Would you use inhaled steroids with or without oral steroids for the treatment of radiation pneumonitis?

Would inhaled steroids help reduce the PO dose and/or significantly accelerate tapering? If s, for what pneumonitis grade? What specific steroid...

1 Answer available

How do you treat an AAV patient with recurrent bronchial stenosis that has not responded to rituximab induction therapy and dilatations?

1 Answer available

Are there any concerns about using nintedanib in a patient with progressive fibrosing ILD on background mycophenolate?

1 Answer available

Is positive pleural fluid cytology from pleural mesothelioma considered M+?

Should patient be considered for definitive therapy or chemo alone if pleural cytology positive but no T4, N2, or sarcomatoid features?

1 Answer available

How do you treat CTD-associated organizing pneumonia?

How is your approach to treatment different than other ILD patterns such as NSIP? Does treatment response vary based on underlying CTD?

2 Answers available

How will you use tocilizumab in the treatment algorithm for SSc-ILD, given its recent FDA approval?

1 Answer available

How do you treat RA in patients with pulmonary mycobacterium avium complex (MAC) infections?

1 Answer available

How do you manage end-organ toxicity such as hepatotoxicity or pulmonary toxicity in a patient receiving RET-inhibitors for NSCLC?

3 Answers available

What is your approach to treatment for MDA5 dermatomyositis patients with rapidly progressive ILD?

Cyclophosphamide/tacrolimus and Rituximab have been used in conjunction with steroids in case series.

1 Answer available

Is there a role for anti-IL6 therapy in SSc-associated ILD?

1 Answer available

Are there AAV patients for whom you would consider combination therapy with cyclophosphamide and rituximab?

1 Answer available

Can liquid biopsy be substituted for tissue biopsy in a lung mass that is radiologically suspicious for primary lung cancer when CT-guided biopsy cannot be done?

For example, a patient with a large (>3cm), spiculated, FDG-avid lung lesion, who has poor lung function and is refusing a CT-guided biopsy?

2 Answers available

What is considered an adequate treatment period to assess response of AAV induction therapy with rituximab or cyclophosphamide?

1 Answer available

Which EGPA patients are most likely to benefit from treatment with anti-IL-5 agents such as mepolizumab?

1 Answer available

What steroid sparing agent do you use for treatment of cardiac sarcoidosis?

Does the type of cardiac involvement impact this choice?

2 Answers available

Should MTX be avoided in RA patients with asymptomatic lung nodules?

If so, what would be an ideal DMARD in this setting?

1 Answer available

What is the optimal management of patients with stage II lung cancer without nodal metastasis, but unresectable due to poor pulmonary reserve?

For T2bN0 or T3N0 disease, you consider radiation alone, sequential radiation followed by chemotherapy, or concurrent chemoradiation?

2 Answers available

Do you consider cystic fibrosis a contraindication to lung SBRT for primary NSCLC or oligometastases?

1 Answer available

How would you manage a patient with newly diagnosed locally advanced NSCLC and concurrent, active tuberculosis on anti-TB therapy?

After initiation of anti-TB treatment and 3 negative AFB smears, would you initiate concurrent chemoRT? Would you give sequential RT then chemo to giv...

1 Answer available

Are there patients who can forgo anticoagulation with asymptomatic, incidentally discovered subsegmental pulmonary embolism?

If there are a low-risk patients who can be monitored, how would you do so? If unprovoked, would you consider stopping anticoagulation?

2 Answers available

Which ANCA vasculitis patients are better candidates for cyclophosphamide rather than rituximab?

2 Answers available

How does your treatment algorithm differ for drug-induced ANCA vasculitis compared to non drug-induced ANCA vasculitis in cases with severe/organ-threatening manifestations?

1 Answer available

Are there certain subsets of ANCA vasculitis patients for whom you would consider life long maintenance therapy?

2 Answers available

When a patient presents with 2 lung lesions, do you routinely recommend a biopsy of both lung lesions?

Would your practice change if the patient had N2 disease?

1 Answer available

Should methotrexate be categorically avoided in RA patients with COPD or RA-ILD?

1 Answer available

How do you manage calcium and vitamin D supplementation in patients with sarcoidosis on chronic steroids?

1 Answer available

What clinical factors do you use to determine timing of on-demand dosing of rituximab in ANCA vasculitis maintenance therapy?

1 Answer available

Do you recommend on-demand versus fixed-schedule dosing for rituximab maintenance in ANCA vasculitis?

If you use both, how do you decide which to use for a particular patient?

2 Answers available

What is the role of nintedanib in the treatment of SSc-ILD?

The SENSCIS trial was published in 2019 on efficacy of this agent. However, it's not clear where this should be in the treatment algorithm: Monot...

2 Answers available

When do you use tacrolimus in patients with myositis-related interstitial lung disease?

1 Answer available

How do you manage early and symptomatic fibrosis in lung cancer patients after RT?

I’ve noticed some patients develop worsening SOB and DOE months after RT and rather than interstitial diffuse pattern you would see with pneumon...

2 Answers available

What agent do you try next in patients with myositis-related interstitial lung disease who are refractory to mycophenolate mofetil and azathioprine?

1 Answer available

When do you stop immunosuppressants in patients with GPA?

1 Answer available

What is your next step in patients with polymyositis without interstitial lung disease who are refractory to methotrexate?

1 Answer available

Is there an increased risk of pneumonitis in COVID-19+ patients receiving lung irradiation?

Any differences in the risks between SBRT vs. conventionally fractionation? Concurrent immunotherapy?

1 Answer available

How do you treat extensive stage small cell lung cancer in the very elderly (more than 80 yrs)?

1 Answer available

Do you use an age limit cutoff for SBRT in lung cancer?

Is there a certain age beyond which it is not safe to do SBRT?

1 Answer available

How has COVID-19 altered your recommendations for invasive mediastinal staging for NSCLC?

Should staging and treatment decisions be made based on imaging alone?

2 Answers available

How would you treat a patient with extensive-stage small cell carcinoma and severe end-stage COPD on home oxygen?

Would you treat with chemotherapy (carboplatin/etoposide) vs anti-pd-1 monotherapy vs combination chemoimmunotherapy vs supportive care?

2 Answers available

In a patient with ILD and metastatic NSCLC with positive PD-L1, would you give chemo/pembrolizumab, chemotherapy alone, or pembrolizumab alone?

Does the degree of PD-L1 expression weigh into your decision?

1 Answer available

How do you approach elderly patients with stage III NSCLC who have a reasonable performance status?

Do you recommend or make any modifications in the PACIFIC regimen for patients > 75 years of age?

1 Answer available

How do you identify immunotherapy-related pneumonitis vs. radiation pneumonitis in a patient status post chemoradiation receiving consolidation immunotherapy?

Is IO related pneumonitis in the radiation field or more diffuse?

1 Answer available

What is your approach for a primary tracheal squamous cell carcinoma?

If clinically node negative, would you add elective nodal radiation?Does it depend on location (upper vs. lower trachea)?

1 Answer available

Should patients with idiopathic pulmonary fibrosis be placed on nintedanib or pirfenidone before starting radiotherapy for lung cancer?

1 Answer available

How important is a severely diminished diffusion capacity in determining whether to offer a lung cancer patient radiotherapy?

Does it factor into your decision making in the setting of restricted spirometry and normal lung volumes? Does this differ for SBRT v. chemoRT?

1 Answer available

How would you manage palliation in a patient with postobstructive pneumonia caused by a mediastinal mass?

Would you treat if there is active infection? How much improvement would you expect?

1 Answer available

How are you using liquid biopsy in the routine management of your patients with metastatic NSCLC?

Are you using ctDNA blood tests for targetable mutations at the time of diagnosis, at the time of disease progression, or not at all?

2 Answers available

How do you approach the workup of subcentimeter contralateral nodules in cases of locally advanced NSCLC?

When there is biopsy proven mediastinal disease, do you offer definitive chemoradiation and monitor, or do you try to prove the presence/absence ...

1 Answer available

What factors do you consider to help guide treatment for patients with high grade large cell neuroendocrine cancers of the lung?

Do you incoprate Ki67% or mitotic rate into your treatment decision, and is there any use for somatostatin based imaging such as octreoscan or gallium...

1 Answer available

How do you manage an adult primary rhabdomyosarcoma of the lung/mediastinum?

Is there any role for consolidative RT/CRT to the lung and mediastinum after initial chemo? What dose and fractionation would be most appropriate for ...

1 Answer available

Do you consider idiopathic pulmonary fibrosis a contraindication to lung SBRT?

There are varying reports in the literature which seem to suggest increased rates of Gr 4-5 pneumonitis in IPF patients. How do you manage these...

2 Answers available

Do you use anti-PD-1/anti-PD-L1 therapies in lung cancer patients with a prior history of radiation pneumonitis?

What about patients who are still on steroids for radiation pneumonitis?

1 Answer available

When is it considered inappropriate to omit pathological mediastinal lymph node staging for non-small cell lung cancer?

The NCCN guidelines call for pathological mediastinal lymph node staging for all NSCLC except in solid tumors <1cm and non-solid lesions < ...

3 Answers available

When do you start steroids for radiation pneumonitis?

Following lung RT, I have rarely seen patients present with pneumonia-like symptoms of radiation pneumonitis. I'm more likely to see a patient with wo...

3 Answers available

How do you approach lung tumors with vessel encasement, especially in someone with active hemoptysis?

Is there any concern about hemorrhage from treatment effect on tumor? Would SABR worsen the chance of fatal hemorrhage/hemoptysis and if so, would you...

1 Answer available

What are your criteria for treating a patient with lung SBRT in the absence of a biopsy?

Roughly what percentage of patients are treated without a biopsy?

1 Answer available

If a PET/CT scan is positive for mediastinal lymph node involvement, is a mediastinoscopy or EBUS still required for NSCLC staging?

In practice, do you send patients with N2/3 disease for mediastinal staging if not offered upfront?

1 Answer available

Papers discussed in this category

Radiother Oncol, 2011 Nov

Outcomes of stereotactic ablative radiotherapy following a clinical diagnosis of stage I NSCLC: comparison with a contemporaneous cohort with pathologically proven disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-10-20

Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer.

N Engl J Med, 2023 Feb 09

Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer.

Lancet (London, England), 2022 Apr 23

Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial.

J Thorac Cardiovasc Surg, 2011 Mar

Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non-small cell carcinoma: results of the American College of Surgery Oncology Group Z0030 Trial.

Semin Radiat Oncol, 2015 Oct

Predicting Radiotherapy Responses and Treatment Outcomes Through Analysis of Circulating Tumor DNA.

J. Clin. Oncol., 2008-07-20

Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group.

Chest, 2007 Sep

Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition).

JCO Precision Oncology, 2017 Sep 29

Circulating Tumor DNA in Non–Small-Cell Lung Cancer: A Primer for the Clinician

Sci Rep, 2014 Sep 09

Diagnostic value of circulating free DNA for the detection of EGFR mutation status in NSCLC: a systematic review and meta-analysis.

Medicine (Baltimore),

Blood as a Substitute for Tumor Tissue in Detecting EGFR Mutations for Guiding EGFR TKIs Treatment of Nonsmall Cell Lung Cancer: A Systematic Review and Meta-Analysis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-10-01

Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non-Small-Cell Lung Cancer.

Lung cancer (Amsterdam, Netherlands), 1994-03

Toxicity of thoracic radiotherapy on pulmonary function in lung cancer.

Clin Lung Cancer, 2017 Jul 10

Impact of Pretreatment Interstitial Lung Disease on Radiation Pneumonitis and Survival in Patients Treated With Lung Stereotactic Body Radiation Therapy (SBRT).

J Thorac Oncol,

Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival after stereotactic body radiation therapy for lung cancer.

Clinical lung cancer, 2018-07

Fatal Radiation Pneumonitis in Patients With Subclinical Interstitial Lung Disease.

Int. J. Radiat. Oncol. Biol. Phys., 2017 Mar 15

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016-06

Pre-treatment non-target lung FDG-PET uptake predicts symptomatic radiation pneumonitis following Stereotactic Ablative Radiotherapy (SABR).

Journal of vascular and interventional radiology : JVIR, 2021 Mar 31

Effectiveness of Thermal Ablation and Stereotactic Radiotherapy Based on Stage I Lung Cancer Histology.

Int. J. Radiat. Oncol. Biol. Phys., 2010-06-01

Selective nodal irradiation on basis of (18)FDG-PET scans in limited-disease small-cell lung cancer: a prospective study.

Thorac Cancer, 2017 Apr 24

Relationship between endobronchial ultrasound-guided (EBUS)-transbronchial needle aspiration utility and computed tomography staging, node size at EBUS, and positron emission tomography scan node standard uptake values: A retrospective analysis.

International journal of radiation oncology, biology, physics, 2013-03-01

Poor baseline pulmonary function may not increase the risk of radiation-induced lung toxicity.

Respir. Res., 2018 Apr 24

Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.

Radiographics : a review publication of the Radiological Society of North America, Inc, 2004

Effects of radiation therapy on the lung: radiologic appearances and differential diagnosis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-03

Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.

The New England journal of medicine, 2015-07-16

N Engl J Med, 2017 Nov 16

Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.

The New England journal of medicine, 2018-12-06

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-01-10

Phase I study of accelerated conformal radiotherapy for stage I non-small-cell lung cancer in patients with pulmonary dysfunction: CALGB 39904.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014-04

Management of mediastinal relapse after treatment with stereotactic body radiotherapy or accelerated hypofractionated radiotherapy for stage I/II non-small-cell lung cancer.

Clinical lung cancer, 2017-07

Stereotactic Body Radiotherapy for Large (> 5 cm) Non-Small-Cell Lung Cancer.

Int. J. Radiat. Oncol. Biol. Phys., 2020 Feb 07

Definitive Management of Presumed Synchronous Early Stage Non-Small Cell Lung Cancers: Outcomes and Utility of Stereotactic Ablative Radiation Therapy.

Cureus, 2019 Jun 22

Moderately Hypofractionated Radiotherapy Alone for Stage I-IIB Non-small Cell Lung Cancer.

Lung Cancer, 2009 Jan 24

Fractionated stereotactic body radiation therapy for medically inoperable stage I lung cancer adjacent to central large bronchus.

Radiat Oncol, 2016 Dec 03

SBRT for centrally localized NSCLC - What is too central?

Adv Radiat Oncol, 2020 May 05

Need for Caution in the Diagnosis of Radiation Pneumonitis in the COVID-19 Pandemic.

Cancer Discov, 2020 May 01

Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System.

Lancet, 2020 May 28

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.

Int. J. Radiat. Oncol. Biol. Phys., 2020 Apr 14

Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement.

N Engl J Med, 2020 Feb 13

Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis.

The New England journal of medicine, 2010-07-15

Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis.

Medicine (Baltimore),

The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort.

The New England journal of medicine, 2010-07-15

Rituximab versus cyclophosphamide for ANCA-associated vasculitis.

N. Engl. J. Med., 2019 May 20

Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease.

The Lancet. Respiratory medicine, 2016-09

Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial.

The New England journal of medicine, 2006-06-22

Cyclophosphamide versus placebo in scleroderma lung disease.

J Thorac Oncol, 2020 Feb 24

A Primer on Interstitial Lung Disease and Thoracic Radiation.

Cancer Treat Rev, 2022 Mar 12

Multidisciplinary clinical guidance on trastuzumab deruxtecan (T-DXd)-related interstitial lung disease/pneumonitis-Focus on proactive monitoring, diagnosis, and management.

Archives of internal medicine, 2008-09-22

Methotrexate is not associated with progression of interstitial lung disease in rheumatoid arthritis.

Arthritis and rheumatism, 2010-06

Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study.

Ann. Rheum. Dis., 2018 Apr 25

Comparison of individually tailored versus fixed-schedule rituximab regimen to maintain ANCA-associated vasculitis remission: results of a multicentre, randomised controlled, phase III trial (MAINRITSAN2).

Ann. Rheum. Dis., 2017 May 25

Randomised controlled trial of prolonged treatment in the remission phase of ANCA-associated vasculitis.

Ann. Rheum. Dis., 2018 May 03

Long-term efficacy of remission-maintenance regimens for ANCA-associated vasculitides.

AJR Am J Roentgenol,

Overdiagnosis of Pulmonary Embolism by Pulmonary CT Angiography.

Chest, 2007-07

Natural history of stage I non-small cell lung cancer: implications for early detection.

Radiat Oncol, 2016 Apr 18

The clinical results of proton beam therapy in patients with idiopathic pulmonary fibrosis: a single center experience.

Journal of the National Cancer Institute, 2011-10-05

Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410.

BMC Cancer, 2018 Oct 12

Efficacy and safety of concurrent anti-Cancer and anti-tuberculosis chemotherapy in Cancer patients with active Mycobacterium tuberculosis: a retrospective study.

Semin Arthritis Rheum, 2020 Jun

TNF-alpha inhibition for the treatment of cardiac sarcoidosis.

Intern Med, 2014 Dec 01

Treatment with methotrexate and low-dose corticosteroids in sarcoidosis patients with cardiac lesions.

J Am Heart Assoc, 2019 Sep 06

Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.

Clin Rheumatol, 2007 Mar 30

Cardiac sarcoidosis responding to monotherapy with infliximab.

The New England journal of medicine, 2017-05-18

Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis.

Kidney international reports, 2018-03

Combination Therapy With Rituximab and Cyclophosphamide for Remission Induction in ANCA Vasculitis.

Rheumatology (Oxford),

A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.

Lancet Respir Med, 2020 Aug 28

Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.

N Engl J Med,

Tofacitinib in Amyopathic Dermatomyositis-Associated Interstitial Lung Disease.

Nature reviews. Rheumatology, 2018-05

Treatment in myositis.

Trials, 2017 Jun 15

Rituximab versus cyclophosphamide for the treatment of connective tissue disease-associated interstitial lung disease (RECITAL): study protocol for a randomised controlled trial.

N Engl J Med, 2019 Sep 29

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases.

Arthritis Rheumatol, 2021 Feb 03

Tocilizumab Prevents Progression of Early Systemic Sclerosis Associated Interstitial Lung Disease.

N Engl J Med, 2012 May 20

Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis.

Journal of thoracic disease, 2013-12

Guidelines for the diagnosis and treatment of malignant pleural mesothelioma.

Thorac Surg Clin, 2020 Sep 12

The Staging of Malignant Pleural Mesothelioma.

Sleep Med Rev, 2021 Jun 10

REM sleep behavior disorder: Mimics and variants.

J Heart Lung Transplant, 2021 Nov

Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation.

Interact Cardiovasc Thorac Surg, 2015 Jan 07

Recurrent polymyositis-associated lung disease after lung transplantation.

Rheumatology (Oxford, England), 2011 Dec 30

Disappearance of anti-MDA-5 autoantibodies in clinically amyopathic DM/interstitial lung disease during disease remission.

Annals of the rheumatic diseases, 2022 Nov 03

2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases.

Frontiers in immunology, 2021 Apr 12

Using Routine Laboratory Markers and Immunological Indicators for Predicting Pneumonia in Immunocompromised Patients.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010-02

Split-course palliative radiotherapy for advanced non-small cell lung cancer.

International journal of radiation oncology, biology, physics, 1980-08

A randomized study of split-course radiotheray of lung cancer: long term results.

Journal for immunotherapy of cancer, 2017-11-21

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.

J Immunother Cancer, 2021 Feb

Success and failure of additional immune modulators in steroid-refractory/resistant pneumonitis related to immune checkpoint blockade.

J Natl Compr Canc Netw,

NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities, Version 1.2020.

Ann Oncol,

Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

J Immunother Cancer,

Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes.

J Immunother Cancer,

Real-world insights on preferred treatments for steroid-refractory immune checkpoint inhibitor-induced pneumonitis.

J Clin Oncol, 2021 Dec 20

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update.

J Natl Compr Canc Netw,

Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology.

Ann Intern Med,

Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial.

Ann Rheum Dis, 2011 Nov 29

Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up.

Respir Med, 2012 Apr 09

The treatment of pulmonary sarcoidosis.

Am J Respir Crit Care Med,

Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999.

Arthritis Rheum,

A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma.

Eur Heart J, 2015 Aug 29

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).

Eur Respir J, 2019 Jan 24

Diagnosis of pulmonary hypertension.

BMJ Open, 2019 May 05

Is incident rheumatoid arthritis interstitial lung disease associated with methotrexate treatment? Results from a multivariate analysis in the ERAS and ERAN inception cohorts.

Rheumatol Int, 2021 Jan 29

Does methotrexate cause progressive fibrotic interstitial lung disease? A systematic review.

N Engl J Med, 2020 Sep 19

Osimertinib in Resected -Mutated Non-Small-Cell Lung Cancer.

J Clin Oncol, 2021 Nov 02

Randomized Phase III Study of Gefitinib Versus Cisplatin Plus Vinorelbine for Patients With Resected Stage II-IIIA Non-Small-Cell Lung Cancer With Mutation (IMPACT).

The European respiratory journal, 2014-11

Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis.

Clin Exp Rheumatol, 2019 Nov 20

Use of third-line therapies in advanced sarcoidosis.

N Engl J Med,

Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis.

Lung, 2021 Apr 07

Tofacitinib as a Steroid-Sparing Therapy in Pulmonary Sarcoidosis, an Open-Label Prospective Proof-of-Concept Study.

RMD Open, 2021 Sep

Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.

JAMA,

Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project.

Eur Respir Rev, 2021 Dec 15

Recovering from a pandemic: pulmonary fibrosis after SARS-CoV-2 infection.

Ann Am Thorac Soc,

Persistent Post-COVID-19 Interstitial Lung Disease. An Observational Study of Corticosteroid Treatment.

Ann Am Thorac Soc,

Evaluating the Impact of Stopping Chronic Therapies after Modulator Drug Therapy in Cystic Fibrosis: The SIMPLIFY Clinical Trial Study Design.

American journal of respiratory and critical care medicine, 2010-08-01

Cystic fibrosis pulmonary guidelines: pulmonary complications: hemoptysis and pneumothorax.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2002-10

Use of fluticasone in acute symptomatic pulmonary sarcoidosis.

Eur Respir J,

Randomized trial of inhaled fluticasone propionate in chronic stable pulmonary sarcoidosis: a pilot study.

Eur Respir J,

Inhaled budesonide in pulmonary sarcoidosis: a double-blind, placebo-controlled study. Dutch Study Group on Pulmonary Sarcoidosis.

J Intern Med,

No effect of high-dose inhaled steroids in pulmonary sarcoidosis: a double-blind, placebo-controlled study.

Drugs,

Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview.

Eur Respir J, 2021 Dec 16

ERS clinical practice guidelines on treatment of sarcoidosis.

N Engl J Med, 2021 Jan 13

Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease.

Lancet Respir Med, 2021 Jun 29

Inhaled treprostinil and forced vital capacity in patients with interstitial lung disease and associated pulmonary hypertension: a post-hoc analysis of the INCREASE study.

Radiology, 2012-10

Short-term mortality in acute pulmonary embolism: clot burden and signs of right heart dysfunction at CT pulmonary angiography.

The New England journal of medicine, 2014-04-10

Fibrinolysis for patients with intermediate-risk pulmonary embolism.

The American journal of cardiology, 2016-11-15

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A Narrative Review of Real-World Data on the Safety of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine, 2011-10-01

Delayed access and survival in idiopathic pulmonary fibrosis: a cohort study.

American journal of respiratory and critical care medicine, 2023 Jan 01

Antifibrotics and Reduced Mortality in Idiopathic Pulmonary Fibrosis: Immortal Time Bias.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015-05

Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis.

J Immunother Cancer, 2021 Jul

Timing of steroid initiation and response rates to immune checkpoint inhibitors in metastatic cancer.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016 Jul 07

Azathioprine and Risk of Skin Cancer in Organ Transplant Recipients: Systematic Review and Meta-Analysis.

Arthritis & rheumatology (Hoboken, N.J.), 2019 Oct 21

Safety and Efficacy of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease: A Nationwide, Multicenter Cohort Study.

European journal of cancer (Oxford, England : 1990), 2023 Dec 28

Effects of an immunosuppressive therapy on the efficacy of immune checkpoint inhibition in metastatic melanoma - An analysis of the prospective skin cancer registry ADOREG.

Arthritis and rheumatism, 2006 Mar

Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis.

Rheumatology (Oxford, England), 2021 Dec 24

Abatacept in monotherapy vs combined in interstitial lung disease of rheumatoid arthritis-multicentre study of 263 Caucasian patients.

Transplantation, 2024 Mar 28

Comparing Plasma Donor-derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study.

Transplant international : official journal of the European Society for Organ Transplantation, 2023 Oct 30

Absolute Quantification of Donor-Derived Cell-Free DNA in Pediatric and Adult Patients After Heart Transplantation: A Prospective Study.

Infection control and hospital epidemiology, 2018-05

Time to Detection in Culture Supports Prediction of Low Transmissibility of Tuberculosis and Discontinuation of Isolation for Low-Risk Patients With A Single AFB-Negative and NAAT-Negative Respiratory Specimen.

Clinical microbiology reviews, 2018-10

Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.

JAMA internal medicine, 2018-10-01

Association of Rapid Molecular Testing With Duration of Respiratory Isolation for Patients With Possible Tuberculosis in a US Hospital.

American journal of respiratory and critical care medicine, 2021 Jan 15

The Epidemiological Importance of Subclinical Tuberculosis. A Critical Reappraisal.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024 Apr 18

NTCA Guidelines for Respiratory Isolation and Restrictions to Reduce Transmission of Pulmonary Tuberculosis in Community Settings.

The New England journal of medicine, 2024 Apr 04

Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19.

Muscle & nerve, 2023 Nov 17

Electrodiagnostic and ultrasound evaluation of respiratory weakness.

The Journal of infectious diseases, 1980 Mar

A study of cephalothin and desacetylcephalothin in cerebrospinal fluid in therapy for experimental pneumococcal meningitis.

Antimicrobial agents and chemotherapy, 1976 Sep

Pharmacological study of cefazolin during intermittent and continuous infusion: a crossover investigation in humans.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020 May 08

Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis.

Lancet, 2021 Sep 20

Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial.

J Clin Oncol, 2023 Jan 31

Adjuvant Osimertinib for Resected EGFR-Mutated Stage IB-IIIA Non-Small-Cell Lung Cancer: Updated Results From the Phase III Randomized ADAURA Trial.

The New England journal of medicine, 2023 Jun 03

Perioperative Pembrolizumab for Early-Stage Non-Small-Cell Lung Cancer.

The New England journal of medicine, 2024 Apr 11

Alectinib in Resected -Positive Non-Small-Cell Lung Cancer.

The New England journal of medicine, 2024 May 16

Perioperative Nivolumab in Resectable Lung Cancer.

Clinical lung cancer, 2024 Feb 13

Perioperative Immunotherapy for Non-Small Cell Lung Cancer: Practical Application of Emerging Data and New Challenges.

N Engl J Med, 2023 Jun 28

Perioperative Nivolumab and Chemotherapy in Stage III Non-Small-Cell Lung Cancer.

The Lancet. Infectious diseases, 2020 Dec 14

Effectiveness of adjunctive clindamycin in β-lactam antibiotic-treated patients with invasive β-haemolytic streptococcal infections in US hospitals: a retrospective multicentre cohort study.

Open forum infectious diseases, 2023 Nov 24

Comparison of Adjuvant Clindamycin vs Linezolid for Severe Invasive Group A Skin and Soft Tissue Infections.

The Journal of allergy and clinical immunology, 2004 Mar

Contamination of dry powder inhalers for asthma with milk proteins containing lactose.

Journal of clinical medicine, 2022 Dec 10

Lactose-Containing Dry-Powder Inhalers for Patients with Cow's Milk Protein Allergy-The Conundrum; A National Survey of Pediatric Pulmonologists and Allergologists.

The New England journal of medicine, 2011-08-04

Reduced lung-cancer mortality with low-dose computed tomographic screening.

Nature reviews. Cancer, 2007-10

Lung cancer in never smokers--a different disease.

N. Engl. J. Med., 2020 Jan 29

Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial.

The Lancet regional health. Europe, 2021 Sep 11

Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018 Nov 13

Role of Low-Dose Computerized Tomography in Lung Cancer Screening among Never-Smokers.

Translational lung cancer research, 2020 Feb

Low-dose CT lung cancer screening in never-smokers and smokers: results of an eight-year observational study.

Addiction (Abingdon, England), 2024 May 22

Changes in self-reported cannabis use in the United States from 1979 to 2022.

Journal of the American Heart Association, 2024 Feb 28

Association of Cannabis Use With Cardiovascular Outcomes Among US Adults.

Frontiers in pharmacology, 2024 May 22

Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, and .

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009-07-01

Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America.

Open forum infectious diseases, 2024 May 02

Should Blood Cultures Be Drawn Through an Indwelling Catheter?

Journal of palliative medicine, 2003 Oct

Ventilator withdrawal protocol.

Current opinion in pulmonary medicine, 2023 Jun 30

Interstitial lung disease in patients with anti-neutrophil cytoplasm antibody-associated vasculitis: an update on pathogenesis and treatment.

Rheumatology (Oxford, England), 2023 Feb 01

Interstitial lung disease in ANCA-associated vasculitis: associated factors, radiographic features and mortality.

Lancet (London, England), 2021 Mar 27

Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial.

Lancet (London, England), 2021 Mar 27

How low can we go in community-acquired pneumonia therapy?

JAMA internal medicine, 2024 May 13

Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018-05-17

Detecting Infections Rapidly and Easily for Candidemia Trial, Part 2 (DIRECT2): A Prospective, Multicenter Study of the T2Candida Panel.

American journal of respiratory and critical care medicine, 2023 Aug 15

Ensifentrine, a Novel Phosphodiesterase 3 and 4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease: Randomized, Double-Blind, Placebo-controlled, Multicenter Phase III Trials (the ENHANCE Trials).

JAMA, 2023 Dec 19

Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial.

The New England journal of medicine, 2013-09-05

Door-to-balloon time and mortality among patients undergoing primary PCI.

The New England journal of medicine, 2024 Jun 21

Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity.

International journal of cardiology. Heart & vasculature, 2021 Apr 29

Non-steroidal treatment of cardiac sarcoidosis: A systematic review.

The Lancet. Haematology, 2021 Aug 04

Early switch to oral anticoagulation in patients with acute intermediate-risk pulmonary embolism (PEITHO-2): a multinational, multicentre, single-arm, phase 4 trial.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2023 Jan-Dec

Retrospective Analysis of Direct-Acting Oral Anticoagulants (DOACs) Initiation Timing and Outcomes After Thrombolysis in High- and Intermediate-Risk Pulmonary Embolism.

The European respiratory journal, 2005-11

Interpretative strategies for lung function tests.

The European respiratory journal, 2022 Jul 13

ERS/ATS technical standard on interpretive strategies for routine lung function tests.

Lupus, 2014 Jul 30

Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections.

MMWR. Morbidity and mortality weekly report, 2024 Sep 12

Use of 21-Valent Pneumococcal Conjugate Vaccine Among U.S. Adults: Recommendations of the Advisory Committee on Immunization Practices - United States, 2024.

PloS one, 2024 Jun 13

Tolerability and efficacy of switching anti-fibrotic treatment from nintedanib to pirfenidone for idiopathic pulmonary fibrosis.

Journal of the Endocrine Society, 2022 Dec 02

Perioperative Evaluation and Management of Patients on Glucocorticoids.

Diagnostics (Basel, Switzerland), 2021 Apr 20

Glucocorticoid Withdrawal-An Overview on When and How to Diagnose Adrenal Insufficiency in Clinical Practice.

JAMA otolaryngology-- head & neck surgery, 2020 Jan 01

Comparative Treatment Outcomes for Patients With Idiopathic Subglottic Stenosis.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2024 Mar 14

Medical Maintenance Therapy Following Laser Excision in Patients With Granulomatosis With Polyangiitis (GPA)-Associated Subglottic Stenosis.

Neurology, 2001-07-24

Postural change of forced vital capacity predicts some respiratory symptoms in ALS.

The European respiratory journal, 2019-06

ERS statement on respiratory muscle testing at rest and during exercise.

Chest, 2017-03

Use of Mycophenolate Mofetil or Azathioprine for the Management of Chronic Hypersensitivity Pneumonitis.

ERJ open research, 2017-07

Outcomes of immunosuppressive therapy in chronic hypersensitivity pneumonitis.

Chest, 2023 Dec 19

Impact of Antigen Exposure on Outcomes and Treatment Response in Fibrotic Hypersensitivity Pneumonitis.

The European respiratory journal, 2023 Nov 29

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease.

American journal of respiratory and critical care medicine, 2019 Nov 15

Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.

Chest, 2018 Oct 26

The Accuracy of Clinical Staging of Stage I-IIIa Non-Small Cell Lung Cancer: An Analysis Based on Individual Participant Data.

Chest, 2024 Jun 15

The Proposed 9th Edition TNM Classification of Lung Cancer.

The European respiratory journal, 2014 Aug 07

Sarcoidosis and subsequent cancer risk: a Danish nationwide cohort study.

Journal of clinical medicine, 2024 Jan 07

Infectious Complications of Pulmonary Sarcoidosis.

Rheumatology (Oxford),

The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity.

Rheumatology (Oxford, England), 2023 Dec 01

Anti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2004-03

Leflunomide for chronic sarcoidosis.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2000-03

Methotrexate is steroid sparing in acute sarcoidosis: results of a double blind, randomized trial.

Chest, 2003-07

Etanercept for the treatment of stage II and III progressive pulmonary sarcoidosis.

American journal of respiratory and critical care medicine, 2006-10-01

Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement.

Diagnostics (Basel, Switzerland), 2024 Jan 23

A Retrospective Analysis of 2-Year Follow-Up of Patients with Incidental Findings of Sarcoidosis.

Chest, 1999 Aug

Oral prednisolone followed by inhaled budesonide in newly diagnosed pulmonary sarcoidosis: a double-blind, placebo-controlled multicenter study. Finnish Pulmonary Sarcoidosis Study Group.

Respiration; international review of thoracic diseases, 2012 Dec 29

Effect and safety of mycophenolate mofetil in chronic pulmonary sarcoidosis: a retrospective study.

The New England journal of medicine, 2024 Jun 13

Noninvasive Ventilation for Preoxygenation during Emergency Intubation.

Critical care medicine, 2019 Apr

Compared Efficacy of Four Preoxygenation Methods for Intubation in the ICU: Retrospective Analysis of McGrath Mac Videolaryngoscope Versus Macintosh Laryngoscope (MACMAN) Trial Data.

European journal of anaesthesiology, 2015 Dec

Preoxygenation by spontaneous breathing or noninvasive positive pressure ventilation with and without positive end-expiratory pressure: A randomised controlled trial.

The American journal of emergency medicine, 2016 May 28

The utility of noninvasive nasal positive pressure ventilators for optimizing oxygenation during rapid sequence intubation.

The New England journal of medicine, 2024 Sep 10

Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia.

The Lancet. Respiratory medicine, 2024 Jan 15

Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial.

NEJM evidence, 2023 May 22

Nalbuphine Tablets for Cough in Patients with Idiopathic Pulmonary Fibrosis.

Diabetes care, 2024 Aug 01

Hyperglycemic Crises in Adults With Diabetes: A Consensus Report.

Journal of general internal medicine, 2007-01

Air travel and venous thromboembolism: a systematic review.

Blood advances, 2018-11-27

American Society of Hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and nonhospitalized medical patients.

Blood advances, 2023 Nov 28

American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing.

The Lancet. Respiratory medicine, 2013-07

Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials.

The Lancet. Respiratory medicine, 2018-09

Laparoscopic anti-reflux surgery for the treatment of idiopathic pulmonary fibrosis (WRAP-IPF): a multicentre, randomised, controlled phase 2 trial.

The European respiratory journal, 2006 Jan

High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis.

The New England journal of medicine, 2000-05-04

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.

Respiratory care, 2011-11

Long-term survival in patients with tracheostomy and prolonged mechanical ventilation in Olmsted County, Minnesota.

JAMA, 2005 Dec 28

Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis.

Respiratory care, 2011 Oct

Approaches to conventional mechanical ventilation of the patient with acute respiratory distress syndrome.

The New England journal of medicine, 2013 May 20

Prone positioning in severe acute respiratory distress syndrome.

Chest, 2005-01

Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosis.

American journal of respiratory and critical care medicine, 2002 Jan 15

American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001.

Clinics in chest medicine, 2004 Dec

Cryptogenic organizing pneumonia.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2022 Sep 10

Use of biomarkers to individualize antimicrobial therapy duration: a narrative review.

The Lancet. Infectious diseases, 2016 Mar 02

Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial.

Experimental cell research, 1985 Jan

Cell growth, cell division and cell size homeostasis in Swiss 3T3 cells.

JAMA, 2024 Dec 09

Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.

The European respiratory journal, 2020 Aug 06

Bronchoalveolar lavage fluid lymphocytosis in chronic hypersensitivity pneumonitis: a systematic review and meta-analysis.

American journal of respiratory and critical care medicine, 2020 Aug 01

Diagnosis of Hypersensitivity Pneumonitis in Adults. An Official ATS/JRS/ALAT Clinical Practice Guideline.

American journal of respiratory and critical care medicine, 2019-11-01

Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis.

The European respiratory journal, 2021 Mar 04

Leukocyte telomere length and mycophenolate therapy in chronic hypersensitivity pneumonitis.

Pulmonology

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