Questions discussed in this category
CDC Healthcare Guidance
CDC Isolation and Work Restriction Guidance
CDC Immunocompromised Guidance
Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?
Would you consider this for patients on B-cell depleting therapies or more broadly for other immunosuppressive agents?
Would you have a different opinion based on whether it is a new therapy or an existing and previously well-tolerated therapy for the patient?
E.g., inflammatory polyarthritis or inflammatory myopathy with onset within 2 weeks of documented COVID infection
Current guidelines do not support its use, but the EMPACTA trial suggests it may be effective in a subpopulation of patients.
Acknowledging that there is no time for good trials yet in this setting
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Papers discussed in this category
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-10
Lancet Oncol., 2020 Mar 03
Lancet, 2020 Feb 07
N Engl J Med, 2020 Apr 29
Rheumatol Int, 2020 Sep 18
N Engl J Med, 2020 Dec 10
N Engl J Med, 2020 Dec 17
Lancet Rheumatol, 2021 Apr 06
N Engl J Med, 2020 Nov 20
Blood,
Arthritis Rheumatol, 2021 May 24
N Engl J Med, 2021 Aug 04
Semin Hematol,
BMJ Open, 2019 May 05
Rheumatol Int, 2021 Jan 29
Thromb Res, 2021 Jun 25
ACR Open Rheumatol, 2021 Aug 25
Medical sciences (Basel, Switzerland), 2018-09-21
The Journal of clinical investigation, 2021 Dec 15
Molecular systems biology, 2023 Mar 15
BMJ open, 2024 May 13