Do you add a platinum agent to neoadjuvant chemotherapy for triple negative breast cancer in BRCA 1/2 mutation carriers?  

Several studies in the metastatic setting (e.g. the TNT trial) have suggested an improved response and progression free survival with platinums in BRCA –mutant breast cancer. In the neoadjuvant setting, a study of 107 women with breast cancer and BRCA1 mutation, treated with 4 cycles of cispla...

Although the data right now are somewhat mixed for adding platinum to neoadjuvant chemotherapy for TNBC, I am impressed by the TNT trial comparing carboplatin to docetaxel in the subgroup of metastatic BRCA associated cancers. I usually use AC x 4 (q3w) followed by paclitaxel weekly x 12, and add ca...