Do you apply PET-adapted therapy (FLYER trial) and omit radiation therapy for older patients (> 60 years) with early stage, non-bulky, DLBCL?  

The data from FLYER (Poeschel et al., Lancet 2019) demonstrate that in younger patients (18-60) with low-risk, early stage DLBCL, R6CHOP4 was equivalent to RCHOPx6. Additionally, we have the data from SWOG reported by Dan Persky and colleagues that, in patients with nonbulky early stage DLBCL, those...