Do you avoid losartan in patients with hypertension and uric acid nephrolithiasis due to the drugs uricosuric effects?  

This is an important question. I continue to use losartan or other uricosuric drugs in uric acid stone formers. Control/prevention of uric acid stone formation is primarily related to raising urine pH to 6.5 (at least above 6), since uric acid solubility is so strongly dependent on pH. Any minor inc...