Do you check for EGFR and other mutations in patients with squamous cell lung cancer, including in adjuvant setting before considering immunotherapy?  

Yes, I do. Our Cancer Institute performs NGS reflex testing for all patients with newly-diagnosed lung cancer, regardless of stage or histology. Although EGFR or other mutations are less common in squamous cell lung cancer, they do exist, and this also allows for testing for other mutations (MET exo...

Completely agree with Dr. @Sanborn. I have found a handful of squamous NSCLC with driver mutations with a history of "light smoking" (around 20 pack years of smoking) and younger age (around 40 years old) compared to the median of 60 years old when most NSCLC patients are diagnosed. It is rare, but...