Do you consider induction immunotherapy or chemoIO prior to chemoradiation for locally advanced PDL-1> 50% NSCLC if normal tissue constraints are not met?

Traditionally these patients may have received chemotherapy prior to chemoRT.

Answer from: Radiation Oncologist at Academic Institution

If normal tissue constraints can't be met, or significantly higher chance of distant metastatic disease due to extensive local/regional disease, I would consider induction chemo/IO for patients with negative EGFR, ALK mutation and PD-1>1% before definitive chemo/RT in inoperable stage III NSCLC. ...

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Radiation Oncologist at Montefiore Einstein Comprehensive Cancer Center
I agree that chemo/IO would be a standard option f...

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Do you consider induction immunotherapy or chemoIO prior to chemoradiation for locally advanced PDL-1> 50% NSCLC if normal tissue constraints are not met?

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