Do you counsel patients on the risk of dementia following androgen deprivation therapy for prostate cancer?

No, I generally do not counsel men about this risk. The two studies from the same investigator use a data warehouse search algorithm that may not be accurate enough to fully characterize who gets Alzheimer's disease or may not be able to correct for confounding factors that may be different between ...

Yes, I do counsel men on this risk. The absolute risk increase appears low (<1-2%) at 5 years, but the relative risk increase (about 2-fold) is concerning, and appears to be dose/duration related, suggesting a causal relationship. Since we do not understand the causes of Alzheimer's disease or which...

I think that the jury is still out on this association, at least based on the recent literature. The methodology used by Nead et al, JAMA Oncol. 2016 Oct 13, raises some questions in my mind. Most importantly, their study did not control for stage of disease, which I would expect to be a very import...