Do you escalate treatment in patients with myositis who achieve clinical remission but continue to have elevated CPK?  

Typically, patients who are doing well and in remission can have low levels of CK abnormality, which needs to be monitored but not treated. Post myositis improvement, some patient's muscle membrane remains leaky or not perfect, leading to some low levels of elevated CK, which has no clinical signifi...

It's a great question but, in my opinion, a little complicated since it hinges on the clinicians' interpretation of why a patient's CK is elevated. For example, elevated CK could be reflective of ongoing skeletal muscle inflammation and sub-clinical active myositis. Alternatively, CK can also be ele...