Do you give an etoposide-based regimen/more aggressive therapy for lymphoma-associated HLH, such as da-EPOCH-R over R-CHOP?  

The general approach to treat the secondary lymphoma-associated HLH (LA-HLH) is to treat the underlying lymphoma- it works better in B cell lymphoma. Etoposide is probably the only agent consistently that has been shown (in several studies- mostly retrospective) to make a difference in the resolutio...