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Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Triple negative • Neoadjuvant chemotherapy • UPMC • Moffitt Cancer Center • NCI-CCC Breast Tumor Board Question
Do you have a certain tumor size threshold in which you change chemotherapy recommendations for a small, triple negative breast cancer?
(For instance, TCx4 instead of ddAC->T for smaller tumors?)
Does this affect your decision about treating with neoadjuvant versus adjuvant chemotherapy?
Answer from: Medical Oncologist at Community Practice
This is often a subject of heated debate at our breast cancer conference. I tend to favor sequential use of weekly paclitaxel after AC for patients with node-negative TNBC, even if the tumor size is small. Higher proportional benefit has been demonstrated for the addition of a taxane after AC for pa...
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Answer from: Medical Oncologist at Community Practice
There is no such thing as "small" TNBC to the extent that you can take a chance that a curable patient in adjuvant setting may have been a "missed opportunity" when either A or T is not used.This may not apply to Neoadjuvant where one can offer TC before surgery and if residual disease is seen in su...
Comments
Medical Oncologist at Forte, Schleider, Attas, and Condemi
interesting remark ,weighing long term toxicity wi...
interesting remark ,weighing long term toxicity wi...