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Gastrointestinal Cancers • Medical Oncology
Do you offer bevacizumab to patients more than 65 years old with metastatic colon cancer that are KRAS mutant?
There is increased stroke risk after 65 years of age with bevacizumab. Does that stop you from using it?
Answer from: Medical Oncologist at Academic Institution
Great question. I think the data would argue that on a case-by-case basis you can give bevacizumab safely. Metaanalyses suggest that PFS and OS are improved in a statistically significant way with the addition of bev (PFS HR 0.55, OS HR 0.83), but so are AE's (Fistula OR 12.07!!, Arterial embolism O...
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