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Radiation Oncology • Thoracic Malignancies • Medical Oncology • NCI-CCC Tumor Board Question • Non-small cell lung cancer • University of Michigan
Do you offer consolidation chemotherapy prior to durvalumab in locally advanced, unresectable NSCLC?
In clinical practice, consolidation chemotherapy is sometimes used, though this was not implemented in the PACIFIC trial.
Answer from: Medical Oncologist at Community Practice
Despite several approaches to improve outcomes for patients with unresectable stage III NSCLC over the past decades, none have been shown to increase survival before the addition of consolidation durvalumab in the PACIFIC trial. The addition of consolidation chemotherapy was shown to lead to increas...
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Medical Oncologist at Texas Oncology
Do we really want to write that ( earlier initiati...
Do we really want to write that ( earlier initiati...
Medical Oncologist at NYU Winthrop Hospital
I start Durvalumab after completion of Chemothe...
I start Durvalumab after completion of Chemothe...
Answer from: Medical Oncologist at Academic Institution
Ever since the publication of the PACIFIC trial which allowed “induction” chemotherapy prior to chemoradiation but no “consolidation” chemotherapy, I have not been using consolidation chemotherapy. Given that the last 25+ years have barely (if at all) moved the needle (...
In the pacific trial it does not specify what chem...