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Do you offer prostate RT to men with 0-3 bone metastases on conventional imaging when PSMA PET shows a very high number of M1 lesions?
STAMPEDE answer is yes, intuitively it seems there must be a line somewhere though.
For patients staged only with PET that is widely M1, should a CT A/P and bone scan be ordered to determine if the patient may have a survival benefit from prostate RT?
Answer from: Radiation Oncologist at Community Practice
Great question, as we are seeing this clinical scenario more and more in practice. I don't think we have a clear answer on this, and I am curious to know how others would approach this case. There are a few points I'd like to discuss. Many of the CHAARTED low-volume patients are expected t...
Answer from: Radiation Oncologist at Community Practice
This is definitely a case-by-case decision based on many patient-related factors and the exact degree and location of disease burden (is it high volume because there are 6 lesions and not 5?, bulky pelvic nodes, etc), but often yes based on PEACE-1 showing the reduced risks of GU complications and t...
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Radiation Oncologist at Lafayette Radiation Center
Case by case. Never say never. Next generation seq...
Case by case. Never say never. Next generation seq...
Answer from: Radiation Oncologist at Community Practice
I believe the PSMA scan is more sensitive than conventional imaging, so I wouldn't treat with the intention that OS will be impacted. PEACE-1 is another trial that looked at this, presented at ASCO 2023.
Summary: Prostate-only RT doesn't appear to impact OS in 'low-volume' patients, though there is...
I don’t think we fully understand why prosta...
A broader point and then a finer one: I see a lot...
You raise an excellent point
Not sure which comments are directed where. The qu...