Do you recommend checking anti-drug antibodies for patients on TNF inhibitors?
If so, how would positive levels guide your management?
Answer from: at Academic Institution
This is a very good question with direct clinical practice implications. I do not check or follow anti-drug antibodies when using TNF inhibitors for the treatment of rheumatoid arthritis or psoriatic arthritis. There are reports that suggest, on a group level, that these antibodies, if present, impa...
Comments
at Mayo Clinic Health System in Eau Claire There is, at present, insufficient evidence to sup...
at Duke University Medical Center Thank you for your responses! Agree completely and...
I agree with Dr. @Yusuf Yazici, as we have good clinical measures of disease activity and once response is reduced or lost, other alternative medications to use. Therapeutic drug monitoring is more important in IBD where clinical measures are not as easily obtained. Further, as already discussed, an...
Hi all - as the IBD voice here, I do think this is an area where GI and rheumatology practices tend to differ as @Vibeke Strand points out. Many IBD practitioners will proactively check anti-TNF drug concentrations (especially infliximab) early in the course of treatment and adjust dosing accordingl...
There is, at present, insufficient evidence to sup...
Thank you for your responses! Agree completely and...