Do you recommend hydrochlorothiazide to manage polyuria in patients with ADPKD who are on tolvaptan?  

Indeed, this can sometimes be useful in this context. After other troubleshooting, I have had success with polyuria symptoms with some patients. The published benefit is up to ~1.8 L, according to Kramers et al., PMID 35314480. Kidney function can get a bit off during the transition, although should...