Do you recommend obtaining one or two 24-hour urine stone risk profile(s) when evaluating patients with nephrolithiasis?  

I would say that two is optimal, and ideally 1 of these on a work day and 1 on a non-work day. However, the practice setting and clinical situation with the given patient might also determine how hard this is to do in practice, and if you would do this in every patient or set things up differently. ...

Basically, I agree with Dr. @Lieske. The idea of the 24-hour urine supersaturation is to identify risk factors for the formation of kidney stones. Since the composition of the 24-hour urine in part is dietary dependent, and most people do not eat the same thing day after day, I think it is wise to l...

I agree with the statements above. I like to have 2 urine collections for the first visit, since diets (and therefore urine chemistries) do vary day to day, and work days are different than weekends. Some diet and patient sensitivities are only evident after 3 or more collections, so follow up studi...