Do you recommend performing a kidney biopsy in patients with suspected ifosfamide nephrotoxicity?  

AKI from ifosfamide occurs as a result of direct tubular toxicity of the drug as well as from pre-renal azotemia as a result of nausea/vomiting/anorexia/diarrhea. The urine sediment is usually inactive. The creatinine generally plateaus within 7-10 days. The presence of an active urine sediment, sys...