Do you recommend routinely getting periodic 24-hour urine monoclonal protein study for patients with active multiple myeloma?
If so, why?
Answer from: Medical Oncologist at Academic Institution
In short, no. I like to perform at the time of diagnosis and then at key points in the patient's journey if it was grossly abnormal (at the time of a bone marrow biopsy, for example). Patients definitely do not enjoy it. It does allow for IMWG response assessment, which is mandated for pat...
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Medical Oncologist at University of Vermont College of Medicine Outside of a trial why do it at all? What decision...
Medical Oncologist at University of Chicago I do not begrudge anyone who eschews the 24 hr uri...
Medical Oncologist at Medical University of South Carolina Agree with all points stated, and, in particular, ...
Answer from: Medical Oncologist at Academic Institution
Lugging a gallon jug of urine to a clinic visit is the kind of minor indignity that is easy for us to discount, but that can weigh heavily on some patients.
Urine studies are occasionally useful to differentiate light chain cast nephropathy or amyloidosis from other forms of kidney injury. But in g...
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Medical Oncologist at Medical University of South Carolina Historically (before FLC assay was developed ), 24...
Answer from: Medical Oncologist at Academic Institution
Excellent question - the only addition I'll make to @Ben Derman's excellent answer is that these tests rarely even change IMWG response criteria either. We've studied this here (ASH abstract below, manuscript under review):
Natsuhara et al., Blood 2022
And hopefully, a registry-based analysis of t...
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Medical Oncologist at Locum Tenens Great poster and title.
Medical Oncologist at University of Washington, Fred Hutchinson Cancer Research Center Thank you @Daniel A. Forman for your kind wor...
Medical Oncologist at Locum Tenens My pleasure @Rahul Banerjee. I haven't ordered a 2...
Medical Oncologist at University of Washington, Fred Hutchinson Cancer Research Center Update for those who may be reading this later: th...
Medical Oncologist at Huntsman Cancer Institute, University of Utah Thank you, @Rahul Banerjee for sharing the update!...
Answer from: Medical Oncologist at Academic Institution
Completely agree with @Ben Derman and @Rahul Banerjee (thanks for that reference).I have always been curious why it still is included in the response criteria.The two places where I have found the value of doing the 24hr monoclonal protein:
MM where FLC ratio >100 is the only myeloma defining ev...
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Medical Oncologist at University of Washington, Fred Hutchinson Cancer Research Center In some ways, theMednet is like trading cards for ...
Outside of a trial why do it at all? What decision...
I do not begrudge anyone who eschews the 24 hr uri...
Agree with all points stated, and, in particular, ...