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Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • UCLA • NCI-CCC Breast Tumor Board Question
Do you use an alternative dosing regimen for CDK4/6 inhibitor in patient with benign ethnic leukopenia?
Following the dosage guidelines based on absolute neutrophil count may cause the patient to end up receiving lower doses.
Answer from: Medical Oncologist at Academic Institution
It is known that patients of african descent have a lower white blood counts (Ethnic Neutropenia). Despite the lower WBC and Neutrophil count, there is no evidence of increased risk of infection. In this setting i usually do not lower the dose, but set a lower cut-point for dose change, or only chan...
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