Does a very high Oncotype score influence your approach to adjuvant treatment in a patient with ER positive breast cancer?  

This is a very intriguing question that has a simple answer. There is no data on choice or aggressiveness of chemotherapy and resulting benefit in patients with higher oncotype recurrence score. What regimen to use remains a judgement call, but for most patients with ER+/node negative tumors with a ...

I agree with @Suleiman A. Massarweh that Oncotype scores facilitate decisions about chemotherapy versus not but they do not inform us as to what regimen to choose. However, I often treat women with high recurrence scores with ddAC-T in the absence of data that we can forgo dose dense anthracycl...