Does the EBCTCG meta-analysis showing higher LRR in NAC group sway you from giving neo-adjuvant chemotherapy to patients with localized breast cancer?  

No. Neoadjuvant chemotherapy was not associated with worse distant recurrences or survival vs. adjuvant chemotherapy. The difference is likely due to more women undergoing breast conserving therapy (and in some cases no surgery in this metanalysis) after neoadjuvant therapy. We know that BCS will ha...