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For 5 fraction lung SBRT, is 11 Gy per fraction superior to 10 Gy per fraction?
The BED10 for 50 Gy in 5 fractions is 100, which is significantly lower then the BED of the 54 Gy in 3 fractions regimen (151). Since the Kestin/Grills paper (PMID#24630539) showed better local control with a BED10>105, should we be pushing the dose to 55 Gy in a 5 fraction plan?
Answer from: Radiation Oncologist at Academic Institution
I will make this brief. Until the results of the prospective dose escalation study RTOG 0813, I would not make any definitive statements on the appropriateness of dose escalation in the setting of lung SBRT. This not only has to do with establishing whether there truly is a dose response phenomenon ...
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Answer from: Radiation Oncologist at Academic Institution
A higher dose may be necessary for lung oligometastases. Norihisa e tal. published a series:Stereotactic body radiotherapy for oligometastatic lung tumors.Norihisa Y, Nagata Y, Takayama K, Matsuo Y, Sakamoto T, Sakamoto M, Mizowaki T, Yano S, Hiraoka M.Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):...