For a patient with IIIC1 (micromets), MSI-high, Grade 2 endometrial adenocarcinoma who has undergone full surgical staging, do you recommend adding immunotherapy to adjuvant chemotherapy + radiation?

Answer from: Radiation Oncologist at Community Practice

Short answer: No, I do not recommend adjuvant CT/IO + RT for this patient based on the patient's risk factors in the prompt, and the data below. Should the patient have recurrent/metastatic disease following adjuvant CT + RT/VCBT, then I/O + CT is a good option. Ongoing trials hope to answer th...

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Radiation Oncologist at Medical College of Wisconsin
Very nice summary of data to help guide all of us....

Answer from: Radiation Oncologist at Academic Institution

No.RUBY only allowed stage IIIC2, any histology, or stage IIIC1 high-risk histology (carcinosarcoma/serous/clear cell) fully resected patients to be enrolled.NRG-GY018 did not allow any fully resected stage III patient to be included. All stage III patients needed to have unresected gross disease.

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at BayCare Medical Group
The crux of the issue is the same question I asked...

at H. Lee Moffitt Cancer Center and Research Institute
Dr. @Logan Corey, thanks for the shout-out on that...

Radiation Oncologist at Vanderbilt-Ingram Cancer Center
@Logan Corey, happy to discuss and help each side ...

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For a patient with IIIC1 (micromets), MSI-high, Grade 2 endometrial adenocarcinoma who has undergone full surgical staging, do you recommend adding immunotherapy to adjuvant chemotherapy + radiation?

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