For metastatic prostate cancer, when would you add carboplatin to docetaxel or cabazitaxel?

There is no clear consensus on this topic. However, I consider carboplatin plus docetaxel or cabazitaxel in men with the following features who are fit for chemotherapy and wish to be aggressive in their care, based on Paul Corn's MD Anderson trial (PMID 31515154):

1. Aggressive variant phenotypic feat...