For patients who meet criteria to be treated with 3 months of CAPEOX based on IDEA study, is it reasonable to use capecitabine alone for 3 months and drop oxaliplatin during the COVID pandemic?

This is indeed a question for our times. There are no data to support three months of capecitabine. In fact, the studies that suggest the single agent fluoropyrimidine carries more of the benefit than oxaliplatin are all based on six-month trials.