For patients with locally advanced rectal cancer who desire organ preservation and can tolerate fluoropyrimidine but not oxaliplatin, what is the appropriate treatment approach?   

For patients with locally advanced rectal cancer who desire organ preservation and cannot tolerate oxaliplatin, the appropriate treatment approach would be neoadjuvant, long-course radiotherapy combined with fluoropyrimidine-based chemotherapy.  After neoadjuvant treatment,...

It will depend on the extent of the disease. CRT with 5-FU/LV can achieve organ preservation in appropriately selected patients (Habr-Gama et al., PMID 30870223). I would like to add systemic chemo if bulky disease (T4 tumors, N2 disease), EMVI, etc. However, patients should be counseled that NOM is...