For patients with well differentiated NET whose carcinoid symptoms are controlled on SSAs but have persistently elevated 5HIAA, would you consider adding telotristat for prevention of carcinoid heart disease?

How aggressive should we be in bringing elevated plasma/urine 5HIAA to normal levels in patients whose symptoms are controlled? Before we have the results of the ongoing study, should we routinely consider adding telotristat?

Medical Oncologist

I do not think routinely adding therapies to treat biochemical parameters is appropriate.As many are likely aware, the tryptophan hydroxylase inhibitor telotristat was approved for the treatment of carcinoid syndrome diarrhea based on the TELESTAR study, which demonstrated a statistically significan...

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For patients with well differentiated NET whose carcinoid symptoms are controlled on SSAs but have persistently elevated 5HIAA, would you consider adding telotristat for prevention of carcinoid heart disease?

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