Given improved BFS from the phase III FLAME trial, do you recommend focal SIB up to 95 Gy for unfavorable and high risk prostate patients?  

As yet, I have not tried to dose escalate to that level using EBRT, preferring to use a brachytherapy boost if I feel patients might require more than I can safely deliver to the whole gland using IMRT. That said, however, I do not think that it would be wrong to try to deliver a focal boost using I...