How are you sequencing immunotherapy with zolbetuximab in locally advanced/metastatic GEJ cancer when CPS >5 and Claudin 18.2+ (>75%)?

With first line approvals in both FOLFOX/Nivo and FOLFOX/zolbetuximab, how are you sequencing treatment if both CPS/Claudin markers are adequate to treat with either therapy, barring no contraindication to either treatment?

Answer from: Medical Oncologist at Academic Institution

In Claudin+: CPS 5 and above, would do checkpoint+ chemo CPS less than 5, would do chemo +zolbe. There is an ongoing study that will answer the question of the quadrable therapy. Till then, would do as the above given that CPI can give us OS benefit, and also ORR benefit, which was not ver...

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Medical Oncologist at UPMC Hillman Cancer Center
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How are you sequencing immunotherapy with zolbetuximab in locally advanced/metastatic GEJ cancer when CPS >5 and Claudin 18.2+ (>75%)?

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