How do you approach a patient with an anaplastic plasmacytoma without systemic evidence of disease in the bone marrow?

What about multiple anaplastic plasmacytoma without bone marrow involvement?

Answer from: Medical Oncologist at Community Practice

I'm not sure what an anaplastic plasmacytoma is. Is it a plasmacytoma that is made up of amorphous cells that express CD138, are clonal, and don't express EBER, ALK, or HHV8? This seems to follow along the lines of what is a plasmablastic neoplasm. If there are no clonal plasma cells in the ma...

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Medical Oncologist at University of Chicago
Anaplastic plasmacytomas, or sometimes referred to...

Medical Oncologist at UW Madison
See also this question for some additional discuss...

Answer from: Medical Oncologist at Academic Institution

Agreed with @Craig C. Hofmeister on all fronts above. I'll specifically touch on the follow-up question (multiple biopsy-proven anaplastic plasmacytomas but BM neg). My vote, in that case, would be to repeat the bone marrow, since I'd argue that the chances of this scenario truly unfolding are...

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How do you approach a patient with an anaplastic plasmacytoma without systemic evidence of disease in the bone marrow?

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