How do you approach borderline non-regional mediastinum lymph nodes when treating locally advanced esophageal cancer?  

I basically consider any nodal disease in the mediastinum from esophageal cancer to be operationally regional disease and would include those areas in the radiation fields if feasible. The comment about the nodes being borderline positive is an ambiguity that cannot be resolved in a forum like this....

I agree with Dr. @Joel E. Tepper and Dr. @Joshua E. Meyer. It’s not clear what is meant by non-regional, but essentially – mediastinal disease can be considered regional – though the extent and location may dictate (based on toxicity profile) what is a reasonable RT field, etc. And...