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Topics:
Internal Medicine • Psoriasis • Allergy & Immunology • Dermatology • Atopic Dermatitis • Drug Eruptions • Allergic Skin Diseases
How do you approach patients that develop atopic dermatitis while on biologics for psoriasis?
I have an elderly patient with a history of biopsy-proven psoriasis on IL-17 biologic therapy. She has developed an intense itch without a primary rash that has not improved with topicals and workup has been unremarkable. Any contraindications to starting Dupixent? We are aware of a publication in JAAD that studied the concomitant administration of dual-biologic therapies (Brumfiel et al., PMID 34022319) but wonder if these trends are seen clinically.
Answer from: at Academic Institution
We have a few patients on dual-biologic therapy who have features of both psoriasis and atopic dermatitis, where each is severe enough to merit systemic therapy on their own. Probably a little less now with more JAK inhibitors available, but we still have some patients maintaining on these regimens....
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